The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes
Abstract Objectives To evaluate the effect at a one-year follow-up after an 18-month randomized controlled trial (RCT) of 90 gm/day low-carbohydrate diet (LCD) in type 2 diabetes. Research design and methods Eighty-five poorly controlled type 2 diabetic patients with an initial HbA1c ≥ 7.5% who have...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-04-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-022-00193-4 |
| _version_ | 1819045684094959616 |
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| author | Chin-Ying Chen Wei-Sheng Huang Ming-Hua Ho Chin-Hao Chang Long-Teng Lee Heng-Shuen Chen Yow-Der Kang Wei-Chu Chie Chyi-Feng Jan Wei-Dean Wang Jaw-Shiun Tsai |
| author_facet | Chin-Ying Chen Wei-Sheng Huang Ming-Hua Ho Chin-Hao Chang Long-Teng Lee Heng-Shuen Chen Yow-Der Kang Wei-Chu Chie Chyi-Feng Jan Wei-Dean Wang Jaw-Shiun Tsai |
| author_sort | Chin-Ying Chen |
| collection | DOAJ |
| description | Abstract Objectives To evaluate the effect at a one-year follow-up after an 18-month randomized controlled trial (RCT) of 90 gm/day low-carbohydrate diet (LCD) in type 2 diabetes. Research design and methods Eighty-five poorly controlled type 2 diabetic patients with an initial HbA1c ≥ 7.5% who have completed an 18-month randomized controlled trial (RCT) on 90 g/day low-carbohydrate diet (LCD) were recruited and followed for one year. A three-day weighted food record, relevant laboratory tests, and medication effect score (MES) were obtained at the end of the previous trial and one year after for a total of 30 months period on specific diet. Results 71 (83.5%) patients completed the study, 35 were in TDD group and 36 were in LCD group. Although the mean of percentage changes in daily carbohydrate intake was significantly lower for those in TDD group than those in LCD group (30.51 ± 11.06% vs. 55.16 ± 21.79%, p = 0.0455) in the period between 18 months and 30 months, patients in LCD group consumed significantly less amount of daily carbohydrate than patients in TDD group (131.8 ± 53.9 g vs. 195.1 ± 50.2 g, p < 0.001). The serum HbA1C, two-hour serum glucose, serum alanine aminotransferase (ALT), and MES were also significantly lower for the LCD group patients than those in the TDD group (p = 0.017, p < 0.001, p = 0.017, and p = 0.008 respectively). The mean of percentage changes of HbA1C, fasting serum glucose, 2 h serum glucose, as well as serum cholesterol, triglyceride, low-density lipoprotein, ALT, creatinine, and urine microalbumin, however, were not significantly different between the two groups (p > 0.05). Conclusions The one-year follow-up for patients on 90 g/d LCD showed potential prolonged and better outcome on glycaemic control, liver function and MES than those on TDD for poorly controlled diabetic patients. |
| first_indexed | 2024-12-21T10:32:29Z |
| format | Article |
| id | doaj.art-28d65de931c84f01a71e48db1f781638 |
| institution | Directory Open Access Journal |
| issn | 2044-4052 |
| language | English |
| last_indexed | 2024-12-21T10:32:29Z |
| publishDate | 2022-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj.art-28d65de931c84f01a71e48db1f7816382022-12-21T19:07:10ZengNature Publishing GroupNutrition & Diabetes2044-40522022-04-011211810.1038/s41387-022-00193-4The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetesChin-Ying Chen0Wei-Sheng Huang1Ming-Hua Ho2Chin-Hao Chang3Long-Teng Lee4Heng-Shuen Chen5Yow-Der Kang6Wei-Chu Chie7Chyi-Feng Jan8Wei-Dean Wang9Jaw-Shiun Tsai10Department of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityDepartment of Dietetics, National Taiwan University Hospital & National Taiwan UniversityDepartment of Medical Research, National Taiwan University Hospital & National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityInstitute of Epidemiology and Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan UniversityAbstract Objectives To evaluate the effect at a one-year follow-up after an 18-month randomized controlled trial (RCT) of 90 gm/day low-carbohydrate diet (LCD) in type 2 diabetes. Research design and methods Eighty-five poorly controlled type 2 diabetic patients with an initial HbA1c ≥ 7.5% who have completed an 18-month randomized controlled trial (RCT) on 90 g/day low-carbohydrate diet (LCD) were recruited and followed for one year. A three-day weighted food record, relevant laboratory tests, and medication effect score (MES) were obtained at the end of the previous trial and one year after for a total of 30 months period on specific diet. Results 71 (83.5%) patients completed the study, 35 were in TDD group and 36 were in LCD group. Although the mean of percentage changes in daily carbohydrate intake was significantly lower for those in TDD group than those in LCD group (30.51 ± 11.06% vs. 55.16 ± 21.79%, p = 0.0455) in the period between 18 months and 30 months, patients in LCD group consumed significantly less amount of daily carbohydrate than patients in TDD group (131.8 ± 53.9 g vs. 195.1 ± 50.2 g, p < 0.001). The serum HbA1C, two-hour serum glucose, serum alanine aminotransferase (ALT), and MES were also significantly lower for the LCD group patients than those in the TDD group (p = 0.017, p < 0.001, p = 0.017, and p = 0.008 respectively). The mean of percentage changes of HbA1C, fasting serum glucose, 2 h serum glucose, as well as serum cholesterol, triglyceride, low-density lipoprotein, ALT, creatinine, and urine microalbumin, however, were not significantly different between the two groups (p > 0.05). Conclusions The one-year follow-up for patients on 90 g/d LCD showed potential prolonged and better outcome on glycaemic control, liver function and MES than those on TDD for poorly controlled diabetic patients.https://doi.org/10.1038/s41387-022-00193-4 |
| spellingShingle | Chin-Ying Chen Wei-Sheng Huang Ming-Hua Ho Chin-Hao Chang Long-Teng Lee Heng-Shuen Chen Yow-Der Kang Wei-Chu Chie Chyi-Feng Jan Wei-Dean Wang Jaw-Shiun Tsai The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes Nutrition & Diabetes |
| title | The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes |
| title_full | The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes |
| title_fullStr | The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes |
| title_full_unstemmed | The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes |
| title_short | The potential prolonged effect at one-year follow-up after 18-month randomized controlled trial of a 90 g/day low-carbohydrate diet in patients with type 2 diabetes |
| title_sort | potential prolonged effect at one year follow up after 18 month randomized controlled trial of a 90 g day low carbohydrate diet in patients with type 2 diabetes |
| url | https://doi.org/10.1038/s41387-022-00193-4 |
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