Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study
Purpose: The effect of pre-existing sarcopenia on patients with oral cavity squamous cell carcinoma (OCSCC) remains unknown. Therefore, we designed a propensity score-matched population-based cohort study to compare the oncological outcomes of patients with OCSCC undergoing curative surgery with and...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/13/3246 |
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| author | Yu-Hsiang Tsai Wan-Ming Chen Ming-Chih Chen Ben-Chang Shia Szu-Yuan Wu Chun-Chi Huang |
| author_facet | Yu-Hsiang Tsai Wan-Ming Chen Ming-Chih Chen Ben-Chang Shia Szu-Yuan Wu Chun-Chi Huang |
| author_sort | Yu-Hsiang Tsai |
| collection | DOAJ |
| description | Purpose: The effect of pre-existing sarcopenia on patients with oral cavity squamous cell carcinoma (OCSCC) remains unknown. Therefore, we designed a propensity score-matched population-based cohort study to compare the oncological outcomes of patients with OCSCC undergoing curative surgery with and without sarcopenia. Patients and Methods: We included patients with OCSCC undergoing curative surgery and categorized them into two groups according to the presence or absence of pre-existing sarcopenia. Patients in both the groups were matched at a ratio of 2:1. Results: The matching process yielded 16,294 patients (10,855 and 5439 without and with pre-existing sarcopenia, respectively). In multivariate Cox regression analyses, the adjusted hazard ratio (aHR, 95% confidence interval [CI]) of all-cause mortality for OCSCC with and without pre-existing sarcopenia was 1.15 (1.11–1.21, <i>p</i> < 0.0001). Furthermore, the aHRs (95% CIs) of locoregional recurrence and distant metastasis for OCSCC with and without pre-existing sarcopenia were 1.07 (1.03–1.18, <i>p</i> = 0.0020) and 1.07 (1.03–1.20, <i>p</i> = 0.0148), respectively. Conclusions: Pre-existing sarcopenia might be a significant poor prognostic factor for overall survival, locoregional recurrence, and distant metastasis for patients with OCSCC undergoing curative surgery. In susceptible patients at a risk of OCSCC, sarcopenia prevention measures should be encouraged, such as exercise and early nutrition intervention. |
| first_indexed | 2024-03-09T22:02:19Z |
| format | Article |
| id | doaj.art-28d6e54d1bc141878cca5212a384e798 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:02:19Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-28d6e54d1bc141878cca5212a384e7982023-11-23T19:46:49ZengMDPI AGCancers2072-66942022-07-011413324610.3390/cancers14133246Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort StudyYu-Hsiang Tsai0Wan-Ming Chen1Ming-Chih Chen2Ben-Chang Shia3Szu-Yuan Wu4Chun-Chi Huang5Department of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanGraduate Institute of Business Administration, College of Management, Fu Jen Catholic University, Taipei 242062, TaiwanDepartment of Otorhinolaryngology, Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Yilan 265, TaiwanPurpose: The effect of pre-existing sarcopenia on patients with oral cavity squamous cell carcinoma (OCSCC) remains unknown. Therefore, we designed a propensity score-matched population-based cohort study to compare the oncological outcomes of patients with OCSCC undergoing curative surgery with and without sarcopenia. Patients and Methods: We included patients with OCSCC undergoing curative surgery and categorized them into two groups according to the presence or absence of pre-existing sarcopenia. Patients in both the groups were matched at a ratio of 2:1. Results: The matching process yielded 16,294 patients (10,855 and 5439 without and with pre-existing sarcopenia, respectively). In multivariate Cox regression analyses, the adjusted hazard ratio (aHR, 95% confidence interval [CI]) of all-cause mortality for OCSCC with and without pre-existing sarcopenia was 1.15 (1.11–1.21, <i>p</i> < 0.0001). Furthermore, the aHRs (95% CIs) of locoregional recurrence and distant metastasis for OCSCC with and without pre-existing sarcopenia were 1.07 (1.03–1.18, <i>p</i> = 0.0020) and 1.07 (1.03–1.20, <i>p</i> = 0.0148), respectively. Conclusions: Pre-existing sarcopenia might be a significant poor prognostic factor for overall survival, locoregional recurrence, and distant metastasis for patients with OCSCC undergoing curative surgery. In susceptible patients at a risk of OCSCC, sarcopenia prevention measures should be encouraged, such as exercise and early nutrition intervention.https://www.mdpi.com/2072-6694/14/13/3246sarcopenianonsarcopeniaOCSCCsurvivalprognosis |
| spellingShingle | Yu-Hsiang Tsai Wan-Ming Chen Ming-Chih Chen Ben-Chang Shia Szu-Yuan Wu Chun-Chi Huang Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study Cancers sarcopenia nonsarcopenia OCSCC survival prognosis |
| title | Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study |
| title_full | Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study |
| title_fullStr | Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study |
| title_full_unstemmed | Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study |
| title_short | Effect of Pre-Existing Sarcopenia on Oncological Outcomes for Oral Cavity Squamous Cell Carcinoma Undergoing Curative Surgery: A Propensity Score-Matched, Nationwide, Population-Based Cohort Study |
| title_sort | effect of pre existing sarcopenia on oncological outcomes for oral cavity squamous cell carcinoma undergoing curative surgery a propensity score matched nationwide population based cohort study |
| topic | sarcopenia nonsarcopenia OCSCC survival prognosis |
| url | https://www.mdpi.com/2072-6694/14/13/3246 |
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