Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions
MiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition via base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.902049/full |
| _version_ | 1818217551225683968 |
|---|---|
| author | Jinxin Tang Jinxin Tang Jieyu He Chengyao Feng Chengyao Feng Chao Tu Chao Tu |
| author_facet | Jinxin Tang Jinxin Tang Jieyu He Chengyao Feng Chengyao Feng Chao Tu Chao Tu |
| author_sort | Jinxin Tang |
| collection | DOAJ |
| description | MiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition via base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies including osteosarcoma. MiRNAs can be transported by exosome, the nano-extracellular vesicle with a diameter of 30–150 nm. Recently, a growing number of studies have demonstrated that exosomal miRNAs play a critical role in tumor initiation and progression, by exerting multiple biological functions including metastasis, angiogenesis, drug resistance and immunosuppression. In this review, we aim to depict the biogenesis of exosomal miRNAs and summarize the potential diagnostic and therapeutic functions of exosomal miRNAs in osteosarcoma. |
| first_indexed | 2024-12-12T07:09:40Z |
| format | Article |
| id | doaj.art-28d791b2e43c4f5fb376b1481478b5f9 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T07:09:40Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-28d791b2e43c4f5fb376b1481478b5f92022-12-22T00:33:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.902049902049Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological FunctionsJinxin Tang0Jinxin Tang1Jieyu He2Chengyao Feng3Chengyao Feng4Chao Tu5Chao Tu6Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaXiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, ChinaMiRNAs are a group of non-coding RNA molecules that function in mRNA translational inhibition via base-pairing with complementary sequences in target mRNA. In oncology, miRNAs have raised great attention due to their aberrant expression and pivotal roles in the pathogenesis of multiple malignancies including osteosarcoma. MiRNAs can be transported by exosome, the nano-extracellular vesicle with a diameter of 30–150 nm. Recently, a growing number of studies have demonstrated that exosomal miRNAs play a critical role in tumor initiation and progression, by exerting multiple biological functions including metastasis, angiogenesis, drug resistance and immunosuppression. In this review, we aim to depict the biogenesis of exosomal miRNAs and summarize the potential diagnostic and therapeutic functions of exosomal miRNAs in osteosarcoma.https://www.frontiersin.org/articles/10.3389/fphar.2022.902049/fullosteosarcomaexosomemiRNAnon-coding RNAbiogenesis |
| spellingShingle | Jinxin Tang Jinxin Tang Jieyu He Chengyao Feng Chengyao Feng Chao Tu Chao Tu Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions Frontiers in Pharmacology osteosarcoma exosome miRNA non-coding RNA biogenesis |
| title | Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions |
| title_full | Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions |
| title_fullStr | Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions |
| title_full_unstemmed | Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions |
| title_short | Exosomal MiRNAs in Osteosarcoma: Biogenesis and Biological Functions |
| title_sort | exosomal mirnas in osteosarcoma biogenesis and biological functions |
| topic | osteosarcoma exosome miRNA non-coding RNA biogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.902049/full |
| work_keys_str_mv | AT jinxintang exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions AT jinxintang exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions AT jieyuhe exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions AT chengyaofeng exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions AT chengyaofeng exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions AT chaotu exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions AT chaotu exosomalmirnasinosteosarcomabiogenesisandbiologicalfunctions |