Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge
Periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the prim...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00065/full |
| _version_ | 1818648599757586432 |
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| author | Suk eJi Youngnim eChoi |
| author_facet | Suk eJi Youngnim eChoi |
| author_sort | Suk eJi |
| collection | DOAJ |
| description | Periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. However, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progresses to the point of no return. Furthermore, the current diagnosis of periodontitis depends on time-consuming clinical measurements. Therefore, there is an unmet need for near-patient testing to diagnose periodontitis. Saliva is an optimal biological fluid to serve as a near-patient diagnostic tool for periodontitis. Recent developments in point-of-care (POC) testing indicate that a diagnostic test for periodontitis using saliva is now technically feasible. A number of promising salivary biomarkers associated with periodontitis have been reported. A panel of optimal biomarkers must be carefully selected based on the pathogenesis of periodontitis. The biggest hurdle for the POC diagnosis of periodontitis using saliva may be the process of validation in a large, diverse patient population. Therefore, we propose the organization of an International Consortium for Biomarkers of Periodontitis, which will gather efforts to identify, select, and validate salivary biomarkers for the diagnosis of periodontitis. |
| first_indexed | 2024-12-17T01:21:00Z |
| format | Article |
| id | doaj.art-28d8fd2c180d49d482ed7f1e695ba5e8 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-17T01:21:00Z |
| publishDate | 2015-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-28d8fd2c180d49d482ed7f1e695ba5e82022-12-21T22:08:50ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882015-09-01510.3389/fcimb.2015.00065156184Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challengeSuk eJi0Youngnim eChoi1Anam Hospital, Korea UniversitySeoul National UniversityPeriodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. Because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. However, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progresses to the point of no return. Furthermore, the current diagnosis of periodontitis depends on time-consuming clinical measurements. Therefore, there is an unmet need for near-patient testing to diagnose periodontitis. Saliva is an optimal biological fluid to serve as a near-patient diagnostic tool for periodontitis. Recent developments in point-of-care (POC) testing indicate that a diagnostic test for periodontitis using saliva is now technically feasible. A number of promising salivary biomarkers associated with periodontitis have been reported. A panel of optimal biomarkers must be carefully selected based on the pathogenesis of periodontitis. The biggest hurdle for the POC diagnosis of periodontitis using saliva may be the process of validation in a large, diverse patient population. Therefore, we propose the organization of an International Consortium for Biomarkers of Periodontitis, which will gather efforts to identify, select, and validate salivary biomarkers for the diagnosis of periodontitis.http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00065/fullPeriodontitisSalivaPoint-of care testingbacteria-derived biomarkershost-derived biomarkers |
| spellingShingle | Suk eJi Youngnim eChoi Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge Frontiers in Cellular and Infection Microbiology Periodontitis Saliva Point-of care testing bacteria-derived biomarkers host-derived biomarkers |
| title | Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge |
| title_full | Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge |
| title_fullStr | Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge |
| title_full_unstemmed | Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge |
| title_short | Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge |
| title_sort | point of care diagnosis of periodontitis using saliva technically feasible but still a challenge |
| topic | Periodontitis Saliva Point-of care testing bacteria-derived biomarkers host-derived biomarkers |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2015.00065/full |
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