Immunologic Diagnosis of Endemic Mycoses
The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/8/10/993 |
| _version_ | 1827649578066771968 |
|---|---|
| author | Rodrigo Almeida-Paes Andrea Reis Bernardes-Engemann Beatriz da Silva Motta Claudia Vera Pizzini Marcos de Abreu Almeida Mauro de Medeiros Muniz Renata Alves Barcelos Dias Rosely Maria Zancopé-Oliveira |
| author_facet | Rodrigo Almeida-Paes Andrea Reis Bernardes-Engemann Beatriz da Silva Motta Claudia Vera Pizzini Marcos de Abreu Almeida Mauro de Medeiros Muniz Renata Alves Barcelos Dias Rosely Maria Zancopé-Oliveira |
| author_sort | Rodrigo Almeida-Paes |
| collection | DOAJ |
| description | The endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can be challenging. Usual laboratory methods involved in endemic mycoses diagnosis include microscopic examination and culture of biological samples; however, serologic, histopathologic, and molecular techniques have been implemented in the last few years for the diagnosis of these mycoses since the recovery and identification of their etiologic agents is time-consuming and lacks in sensitivity. In this review, we focus on the immunologic diagnostic methods related to antibody and antigen detection since their evidence is presumptive diagnosis, and in some mycoses, such as cryptococcosis, it is definitive diagnosis. |
| first_indexed | 2024-03-09T19:59:43Z |
| format | Article |
| id | doaj.art-28d9529d09bc44108449451ce13a85cf |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T19:59:43Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-28d9529d09bc44108449451ce13a85cf2023-11-24T00:46:22ZengMDPI AGJournal of Fungi2309-608X2022-09-0181099310.3390/jof8100993Immunologic Diagnosis of Endemic MycosesRodrigo Almeida-Paes0Andrea Reis Bernardes-Engemann1Beatriz da Silva Motta2Claudia Vera Pizzini3Marcos de Abreu Almeida4Mauro de Medeiros Muniz5Renata Alves Barcelos Dias6Rosely Maria Zancopé-Oliveira7Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilLaboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, BrazilThe endemic mycoses blastomycosis, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, cryptococcosis, sporotrichosis, talaromycosis, adiaspiromycosis, and emergomycosis are mostly caused by geographically limited thermally dimorphic fungi (except for cryptococcosis), and their diagnoses can be challenging. Usual laboratory methods involved in endemic mycoses diagnosis include microscopic examination and culture of biological samples; however, serologic, histopathologic, and molecular techniques have been implemented in the last few years for the diagnosis of these mycoses since the recovery and identification of their etiologic agents is time-consuming and lacks in sensitivity. In this review, we focus on the immunologic diagnostic methods related to antibody and antigen detection since their evidence is presumptive diagnosis, and in some mycoses, such as cryptococcosis, it is definitive diagnosis.https://www.mdpi.com/2309-608X/8/10/993antibodyantigenblastomycosiscoccidioidomycosishistoplasmosisparacoccidioidomycosis |
| spellingShingle | Rodrigo Almeida-Paes Andrea Reis Bernardes-Engemann Beatriz da Silva Motta Claudia Vera Pizzini Marcos de Abreu Almeida Mauro de Medeiros Muniz Renata Alves Barcelos Dias Rosely Maria Zancopé-Oliveira Immunologic Diagnosis of Endemic Mycoses Journal of Fungi antibody antigen blastomycosis coccidioidomycosis histoplasmosis paracoccidioidomycosis |
| title | Immunologic Diagnosis of Endemic Mycoses |
| title_full | Immunologic Diagnosis of Endemic Mycoses |
| title_fullStr | Immunologic Diagnosis of Endemic Mycoses |
| title_full_unstemmed | Immunologic Diagnosis of Endemic Mycoses |
| title_short | Immunologic Diagnosis of Endemic Mycoses |
| title_sort | immunologic diagnosis of endemic mycoses |
| topic | antibody antigen blastomycosis coccidioidomycosis histoplasmosis paracoccidioidomycosis |
| url | https://www.mdpi.com/2309-608X/8/10/993 |
| work_keys_str_mv | AT rodrigoalmeidapaes immunologicdiagnosisofendemicmycoses AT andreareisbernardesengemann immunologicdiagnosisofendemicmycoses AT beatrizdasilvamotta immunologicdiagnosisofendemicmycoses AT claudiaverapizzini immunologicdiagnosisofendemicmycoses AT marcosdeabreualmeida immunologicdiagnosisofendemicmycoses AT maurodemedeirosmuniz immunologicdiagnosisofendemicmycoses AT renataalvesbarcelosdias immunologicdiagnosisofendemicmycoses AT roselymariazancopeoliveira immunologicdiagnosisofendemicmycoses |