Examining genetic associations with hepatic steatosis in Mexican-origin adults
Introduction and Objectives: Various studies have identified single-nucleotide polymorphisms (SNPs) associated with nonalcoholic fatty liver disease (NAFLD) and related traits, including ones located in or near the LYPLAL1, GCKR, PPP1R3B, TM6SF2, MBOAT7, and PNPLA3 genes. However, these SNPs were id...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Annals of Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268123002247 |
| _version_ | 1797733050141900800 |
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| author | Mario Jesus Trejo Kristin E. Morrill Yann C. Klimentidis David O. Garcia |
| author_facet | Mario Jesus Trejo Kristin E. Morrill Yann C. Klimentidis David O. Garcia |
| author_sort | Mario Jesus Trejo |
| collection | DOAJ |
| description | Introduction and Objectives: Various studies have identified single-nucleotide polymorphisms (SNPs) associated with nonalcoholic fatty liver disease (NAFLD) and related traits, including ones located in or near the LYPLAL1, GCKR, PPP1R3B, TM6SF2, MBOAT7, and PNPLA3 genes. However, these SNPs were identified primarily in populations of European ancestry. This study examined the associations of these previously identified SNPs with hepatic steatosis in a sample of Mexican-origin adults living in Southern Arizona. Materials and Methods: A total of 307 Mexican-origin adults between the ages of 18 and 64 with a body mass index (BMI) of 25 kg/m2 or higher were genotyped at the following SNPs: rs12137855 (LYPLAL1), rs1260326 (GCKR), rs4240624 (PPP1R3B), rs58542926 (TM6SF2), rs641738 (MBOAT7), and rs738409 (PNPLA3). Hepatic steatosis was assessed by transient elastography (FibroScan®) with controlled attenuation parameter. Regression models examined the association between each of the six SNPs and hepatic steatosis. BMI was examined as a potential modifier of the genetic associations. Results: Participants were, on average, 45 years old and mostly female (63%) with an overall mean hepatic steatosis of 288.1 dB/m. Models showed no associations between LYPLAL1, GCKR, PPP1R3B, TM6SF2, or MBOAT7 and hepatic steatosis. Only PNPLA3 was statistically significantly associated with hepatic steatosis in both unadjusted and adjusted models (p<0.01). There was no effect modification observed with BMI. Conclusions: SNPs associated with NAFLD in populations of European descent did not strongly contribute to hepatic steatosis in individuals of Mexican-origin, except for rs738409 (PNPLA3). Further efforts are necessary to explore additional SNPs that may be associated with NAFLD in this high-risk population. |
| first_indexed | 2024-03-12T12:23:26Z |
| format | Article |
| id | doaj.art-28d96634a3a644f68d564fe7a48026e7 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-03-12T12:23:26Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-28d96634a3a644f68d564fe7a48026e72023-08-30T05:50:16ZengElsevierAnnals of Hepatology1665-26812023-09-01285101120Examining genetic associations with hepatic steatosis in Mexican-origin adultsMario Jesus Trejo0Kristin E. Morrill1Yann C. Klimentidis2David O. Garcia3Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Corresponding author.Community & Systems Health Science Division, College of Nursing, University of Arizona, Tucson, AZ 85721, USADepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USADepartment of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USAIntroduction and Objectives: Various studies have identified single-nucleotide polymorphisms (SNPs) associated with nonalcoholic fatty liver disease (NAFLD) and related traits, including ones located in or near the LYPLAL1, GCKR, PPP1R3B, TM6SF2, MBOAT7, and PNPLA3 genes. However, these SNPs were identified primarily in populations of European ancestry. This study examined the associations of these previously identified SNPs with hepatic steatosis in a sample of Mexican-origin adults living in Southern Arizona. Materials and Methods: A total of 307 Mexican-origin adults between the ages of 18 and 64 with a body mass index (BMI) of 25 kg/m2 or higher were genotyped at the following SNPs: rs12137855 (LYPLAL1), rs1260326 (GCKR), rs4240624 (PPP1R3B), rs58542926 (TM6SF2), rs641738 (MBOAT7), and rs738409 (PNPLA3). Hepatic steatosis was assessed by transient elastography (FibroScan®) with controlled attenuation parameter. Regression models examined the association between each of the six SNPs and hepatic steatosis. BMI was examined as a potential modifier of the genetic associations. Results: Participants were, on average, 45 years old and mostly female (63%) with an overall mean hepatic steatosis of 288.1 dB/m. Models showed no associations between LYPLAL1, GCKR, PPP1R3B, TM6SF2, or MBOAT7 and hepatic steatosis. Only PNPLA3 was statistically significantly associated with hepatic steatosis in both unadjusted and adjusted models (p<0.01). There was no effect modification observed with BMI. Conclusions: SNPs associated with NAFLD in populations of European descent did not strongly contribute to hepatic steatosis in individuals of Mexican-origin, except for rs738409 (PNPLA3). Further efforts are necessary to explore additional SNPs that may be associated with NAFLD in this high-risk population.http://www.sciencedirect.com/science/article/pii/S1665268123002247SNPsNAFLDNonalcoholic fatty liver disease |
| spellingShingle | Mario Jesus Trejo Kristin E. Morrill Yann C. Klimentidis David O. Garcia Examining genetic associations with hepatic steatosis in Mexican-origin adults Annals of Hepatology SNPs NAFLD Nonalcoholic fatty liver disease |
| title | Examining genetic associations with hepatic steatosis in Mexican-origin adults |
| title_full | Examining genetic associations with hepatic steatosis in Mexican-origin adults |
| title_fullStr | Examining genetic associations with hepatic steatosis in Mexican-origin adults |
| title_full_unstemmed | Examining genetic associations with hepatic steatosis in Mexican-origin adults |
| title_short | Examining genetic associations with hepatic steatosis in Mexican-origin adults |
| title_sort | examining genetic associations with hepatic steatosis in mexican origin adults |
| topic | SNPs NAFLD Nonalcoholic fatty liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S1665268123002247 |
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