High-Density Lipoprotein and Heart Failure
The protective effect of high-density lipoprotein (HDL) on atherosclerosis is well known, and its mechanisms of action has been extensively studied. However, the impact of HDL on heart failure and its mechanisms are still controversial or unknown. The cardioprotective role of HDL may be reflected in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-11-01
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| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/24/11/10.31083/j.rcm2411321 |
| _version_ | 1827592766340726784 |
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| author | Liyun Xing Yixuan Liu Jiayu Wang Peiqing Tian Ping Liu |
| author_facet | Liyun Xing Yixuan Liu Jiayu Wang Peiqing Tian Ping Liu |
| author_sort | Liyun Xing |
| collection | DOAJ |
| description | The protective effect of high-density lipoprotein (HDL) on atherosclerosis is well known, and its mechanisms of action has been extensively studied. However, the impact of HDL on heart failure and its mechanisms are still controversial or unknown. The cardioprotective role of HDL may be reflected in its antioxidant, anti-inflammatory, anti-apoptotic, and endothelial function protection. In epidemiological studies, high-density lipoprotein cholesterol (HDL-C) levels have been negatively associated with heart failure (HF). The major protein component of HDL-C is apolipoprotein (Apo) A-I, while paraoxonase-1 (PON-1) is an essential mediator for many protective functions of HDL, and HDL may act through components like (Apo) A-I or PON-1 to delay heart failure progress. HDL can slow heart failure disease progression through parts like (Apo) A-I or PON-1. The potential causality between HDL and heart failure, the role of HDL in the pathogenesis of HF, and its interaction with C-reactive protein (CRP), triglycerides (TG), and monocytes in the process of heart failure have been briefly summarized and discussed in this article. HDL plays an important role in the pathogenesis, progression and treatment of HF. |
| first_indexed | 2024-03-09T01:59:25Z |
| format | Article |
| id | doaj.art-28da150f17b64e969b7be1a269d0ff4b |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-03-09T01:59:25Z |
| publishDate | 2023-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-28da150f17b64e969b7be1a269d0ff4b2023-12-08T06:09:21ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-11-01241132110.31083/j.rcm2411321S1530-6550(23)01065-7High-Density Lipoprotein and Heart FailureLiyun Xing0Yixuan Liu1Jiayu Wang2Peiqing Tian3Ping Liu4Department of Cardiology, the Second Hospital of Shandong University, 250033 Jinan, Shandong, ChinaSchool of Clinical and Basic Medicine, Shandong First Medical University,250117 Jinan, Shandong, ChinaDepartment of Cardiology, the Second Hospital of Shandong University, 250033 Jinan, Shandong, ChinaDepartment of Cardiology, the Second Hospital of Shandong University, 250033 Jinan, Shandong, ChinaDepartment of Cardiology, the Second Hospital of Shandong University, 250033 Jinan, Shandong, ChinaThe protective effect of high-density lipoprotein (HDL) on atherosclerosis is well known, and its mechanisms of action has been extensively studied. However, the impact of HDL on heart failure and its mechanisms are still controversial or unknown. The cardioprotective role of HDL may be reflected in its antioxidant, anti-inflammatory, anti-apoptotic, and endothelial function protection. In epidemiological studies, high-density lipoprotein cholesterol (HDL-C) levels have been negatively associated with heart failure (HF). The major protein component of HDL-C is apolipoprotein (Apo) A-I, while paraoxonase-1 (PON-1) is an essential mediator for many protective functions of HDL, and HDL may act through components like (Apo) A-I or PON-1 to delay heart failure progress. HDL can slow heart failure disease progression through parts like (Apo) A-I or PON-1. The potential causality between HDL and heart failure, the role of HDL in the pathogenesis of HF, and its interaction with C-reactive protein (CRP), triglycerides (TG), and monocytes in the process of heart failure have been briefly summarized and discussed in this article. HDL plays an important role in the pathogenesis, progression and treatment of HF.https://www.imrpress.com/journal/RCM/24/11/10.31083/j.rcm2411321high-density lipoproteinhigh-density lipoprotein cholesterolheart failureinflammationapolipoprotein |
| spellingShingle | Liyun Xing Yixuan Liu Jiayu Wang Peiqing Tian Ping Liu High-Density Lipoprotein and Heart Failure Reviews in Cardiovascular Medicine high-density lipoprotein high-density lipoprotein cholesterol heart failure inflammation apolipoprotein |
| title | High-Density Lipoprotein and Heart Failure |
| title_full | High-Density Lipoprotein and Heart Failure |
| title_fullStr | High-Density Lipoprotein and Heart Failure |
| title_full_unstemmed | High-Density Lipoprotein and Heart Failure |
| title_short | High-Density Lipoprotein and Heart Failure |
| title_sort | high density lipoprotein and heart failure |
| topic | high-density lipoprotein high-density lipoprotein cholesterol heart failure inflammation apolipoprotein |
| url | https://www.imrpress.com/journal/RCM/24/11/10.31083/j.rcm2411321 |
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