Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study
Abstract Background Higher levels of palmitoyl sphingomyelin (PSM, synonymous with sphingomyelin 16:0) are associated with an increased risk of cardiovascular disease (CVD) in people with diabetes. Whether circulating PSM levels can practically predict the long-term risk of CVD and all-cause death r...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-01-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-02116-8 |
| _version_ | 1797350112590036992 |
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| author | Xin Qian Hongmei Jia Jinping Wang Siyao He Meng Yu Xinxing Feng Qiuhong Gong Yali An Xuan Wang Na Shi Hui Li Zhongmei Zou Guangwei Li Yanyan Chen |
| author_facet | Xin Qian Hongmei Jia Jinping Wang Siyao He Meng Yu Xinxing Feng Qiuhong Gong Yali An Xuan Wang Na Shi Hui Li Zhongmei Zou Guangwei Li Yanyan Chen |
| author_sort | Xin Qian |
| collection | DOAJ |
| description | Abstract Background Higher levels of palmitoyl sphingomyelin (PSM, synonymous with sphingomyelin 16:0) are associated with an increased risk of cardiovascular disease (CVD) in people with diabetes. Whether circulating PSM levels can practically predict the long-term risk of CVD and all-cause death remains unclear. This study aimed to investigate whether circulating PSM is a real predictor of CVD death in Chinese adults with or without diabetes. Methods A total of 286 and 219 individuals with and without diabetes, respectively, from the original Da Qing Diabetes Study were enrolled. Blood samples collected in 2009 were used as a baseline to assess circulating PSM levels. The outcomes of CVD and all-cause death were followed up from 2009 to 2020, and 178 participants died, including 87 deaths due to CVD. Cox proportional hazards regression was used to estimate HRs and their 95% CIs for the outcomes. Results Fractional polynomial regression analysis showed a linear association between baseline circulating PSM concentration (log-2 transformed) and the risk of all-cause and CVD death (p < 0.001), but not non-CVD death (p > 0.05), in all participants after adjustment for confounders. When the participants were stratified by PSM-tertile, the highest tertile, regardless of diabetes, had a higher incidence of CVD death (41.5 vs. 14.7 and 22.2 vs. 2.9 per 1000 person-years in patients with and without diabetes, respectively, all log-rank p < 0.01). Individuals with diabetes in the highest tertile group had a higher risk of CVD death than those in the lowest tertile (HR = 2.73; 95%CI, 1.20–6.22). Conclusions Elevated PSM levels are significantly associated with a higher 10-year risk of CVD death, but not non-CVD death, in Chinese adults with diabetes. These findings suggest that PSM is a potentially useful long-term predictor of CVD death in individuals with diabetes. |
| first_indexed | 2024-03-08T12:40:07Z |
| format | Article |
| id | doaj.art-28db9edbc90d437db015c478a36b3cc2 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-08T12:40:07Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-28db9edbc90d437db015c478a36b3cc22024-01-21T12:09:21ZengBMCCardiovascular Diabetology1475-28402024-01-0123111010.1186/s12933-023-02116-8Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes StudyXin Qian0Hongmei Jia1Jinping Wang2Siyao He3Meng Yu4Xinxing Feng5Qiuhong Gong6Yali An7Xuan Wang8Na Shi9Hui Li10Zhongmei Zou11Guangwei Li12Yanyan Chen13Endocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Da Qing First HospitalEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Da Qing First HospitalInstitute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Endocrinology, China-Japan Friendship HospitalEndocrinology Centre, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Background Higher levels of palmitoyl sphingomyelin (PSM, synonymous with sphingomyelin 16:0) are associated with an increased risk of cardiovascular disease (CVD) in people with diabetes. Whether circulating PSM levels can practically predict the long-term risk of CVD and all-cause death remains unclear. This study aimed to investigate whether circulating PSM is a real predictor of CVD death in Chinese adults with or without diabetes. Methods A total of 286 and 219 individuals with and without diabetes, respectively, from the original Da Qing Diabetes Study were enrolled. Blood samples collected in 2009 were used as a baseline to assess circulating PSM levels. The outcomes of CVD and all-cause death were followed up from 2009 to 2020, and 178 participants died, including 87 deaths due to CVD. Cox proportional hazards regression was used to estimate HRs and their 95% CIs for the outcomes. Results Fractional polynomial regression analysis showed a linear association between baseline circulating PSM concentration (log-2 transformed) and the risk of all-cause and CVD death (p < 0.001), but not non-CVD death (p > 0.05), in all participants after adjustment for confounders. When the participants were stratified by PSM-tertile, the highest tertile, regardless of diabetes, had a higher incidence of CVD death (41.5 vs. 14.7 and 22.2 vs. 2.9 per 1000 person-years in patients with and without diabetes, respectively, all log-rank p < 0.01). Individuals with diabetes in the highest tertile group had a higher risk of CVD death than those in the lowest tertile (HR = 2.73; 95%CI, 1.20–6.22). Conclusions Elevated PSM levels are significantly associated with a higher 10-year risk of CVD death, but not non-CVD death, in Chinese adults with diabetes. These findings suggest that PSM is a potentially useful long-term predictor of CVD death in individuals with diabetes.https://doi.org/10.1186/s12933-023-02116-8All-cause deathCVD deathPredictorPSM |
| spellingShingle | Xin Qian Hongmei Jia Jinping Wang Siyao He Meng Yu Xinxing Feng Qiuhong Gong Yali An Xuan Wang Na Shi Hui Li Zhongmei Zou Guangwei Li Yanyan Chen Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study Cardiovascular Diabetology All-cause death CVD death Predictor PSM |
| title | Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study |
| title_full | Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study |
| title_fullStr | Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study |
| title_full_unstemmed | Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study |
| title_short | Circulating palmitoyl sphingomyelin levels predict the 10-year increased risk of cardiovascular disease death in Chinese adults: findings from the Da Qing Diabetes Study |
| title_sort | circulating palmitoyl sphingomyelin levels predict the 10 year increased risk of cardiovascular disease death in chinese adults findings from the da qing diabetes study |
| topic | All-cause death CVD death Predictor PSM |
| url | https://doi.org/10.1186/s12933-023-02116-8 |
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