MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma

MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma

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MicroRNAs (miRNAs) can regulate tumor cell invasion and metastasis in a tumor-specific manner. We recently demonstrated that global downregulation of miRNAs after deleting dicer can promote development of distant metastases in a mouse model of primary soft tissue sarcoma (STS). In this study, we ide...

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Bibliographic Details
Main Authors: Mohit Sachdeva, Melody J. Whitley, Jeffrey K. Mito, Yan Ma, Dina C. Lev, Diana M. Cardona, David G. Kirsch
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
Genetic engineering
Mouse models
Metastasis
MicroRNA
Soft tissue sarcoma
Online Access:http://dmm.biologists.org/content/8/8/867

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