Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
SAS-6 (SASS6) is essential for centriole formation in human cells and other organisms but its functions in the mouse are unclear. Here, we report that Sass6-mutant mouse embryos lack centrioles, activate the mitotic surveillance cell death pathway, and arrest at mid-gestation. In contrast, SAS-6 is...
| Hlavní autoři: | , |
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| Médium: | Článek |
| Jazyk: | English |
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eLife Sciences Publications Ltd
2024-02-01
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| Edice: | eLife |
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| On-line přístup: | https://elifesciences.org/articles/94694 |