A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma
Cuproptosis, a copper-induced mechanism of mitochondrial-related cell death, has been implicated as a breakthrough in the treatment of cancer and has become a new treatment strategy. Furthermore, long non-coding RNA (lncRNA) can change the biological activities of tumor cells. Worldwide, lung squam...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2023-07-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8481 |
| _version_ | 1827317496815812608 |
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| author | Chunlan Hou Xiuping Wu Caoyang Li Chao Wang Jinbo Liu Qing Luo |
| author_facet | Chunlan Hou Xiuping Wu Caoyang Li Chao Wang Jinbo Liu Qing Luo |
| author_sort | Chunlan Hou |
| collection | DOAJ |
| description |
Cuproptosis, a copper-induced mechanism of mitochondrial-related cell death, has been implicated as a breakthrough in the treatment of cancer and has become a new treatment strategy. Furthermore, long non-coding RNA (lncRNA) can change the biological activities of tumor cells. Worldwide, lung squamous cell carcinoma (LUSC) is among the most common annoying tumors. LncRNAs related to cuproptosis are not researched at LUSC. Our research intends to develop a signature on the basis of cuproptosis-associated lncRNAs, which can predict LUSC prognosis and investigate LUSC immunological features. The TCGA database was used to retrieve LUSC transcriptome, clinical, and gene mutation data. For statistical analysis, we utilized the R program. We created a signature consisting of three cuproptosis-related lncRNAs in this investigation (including AC002467.1, LINC01740, and LINC02345). Survival analyses and Receiver Operating Characteristic curves demonstrated that this signature possessed powerful predictive capability. The signature’s ability to predict was confirmed by a Receiver Operating Characteristic curve and principal component analysis. Notably, the patient with a high-risk score and a high tumor mutation burden level had a lower survival time. Furthermore, the tumor immune dysfunction and exclusion analysis showed that these individuals with low-risk scores may benefit from immunotherapy. The signature constructed by three cuproptosis-associated lncRNAs may be prognostic markers of LUSC. It contributes to immunotherapy and offers LUSC’s therapy a new treatment direction.
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| first_indexed | 2024-04-24T23:39:50Z |
| format | Article |
| id | doaj.art-28e07d82fbd7455282a515cf2779e0e4 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:50Z |
| publishDate | 2023-07-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-28e07d82fbd7455282a515cf2779e0e42024-03-15T13:22:36ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2023-07-0123410.17305/bb.2022.8481A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinomaChunlan Hou0https://orcid.org/0000-0002-1974-5104Xiuping Wu1Caoyang Li2Chao Wang3Jinbo Liu4Qing Luo5https://orcid.org/0000-0003-2596-8862Department of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.Department of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.Department of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.Department of Cardiothoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. Cuproptosis, a copper-induced mechanism of mitochondrial-related cell death, has been implicated as a breakthrough in the treatment of cancer and has become a new treatment strategy. Furthermore, long non-coding RNA (lncRNA) can change the biological activities of tumor cells. Worldwide, lung squamous cell carcinoma (LUSC) is among the most common annoying tumors. LncRNAs related to cuproptosis are not researched at LUSC. Our research intends to develop a signature on the basis of cuproptosis-associated lncRNAs, which can predict LUSC prognosis and investigate LUSC immunological features. The TCGA database was used to retrieve LUSC transcriptome, clinical, and gene mutation data. For statistical analysis, we utilized the R program. We created a signature consisting of three cuproptosis-related lncRNAs in this investigation (including AC002467.1, LINC01740, and LINC02345). Survival analyses and Receiver Operating Characteristic curves demonstrated that this signature possessed powerful predictive capability. The signature’s ability to predict was confirmed by a Receiver Operating Characteristic curve and principal component analysis. Notably, the patient with a high-risk score and a high tumor mutation burden level had a lower survival time. Furthermore, the tumor immune dysfunction and exclusion analysis showed that these individuals with low-risk scores may benefit from immunotherapy. The signature constructed by three cuproptosis-associated lncRNAs may be prognostic markers of LUSC. It contributes to immunotherapy and offers LUSC’s therapy a new treatment direction. https://www.bjbms.org/ojs/index.php/bjbms/article/view/8481Lung squamous cell carcinomacuproptosislong non-coding RNAprognosisimmunotherapy |
| spellingShingle | Chunlan Hou Xiuping Wu Caoyang Li Chao Wang Jinbo Liu Qing Luo A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma Biomolecules & Biomedicine Lung squamous cell carcinoma cuproptosis long non-coding RNA prognosis immunotherapy |
| title | A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma |
| title_full | A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma |
| title_fullStr | A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma |
| title_full_unstemmed | A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma |
| title_short | A cuproptosis-associated long non-coding RNA signature for the prognosis and immunotherapy of lung squamous cell carcinoma |
| title_sort | cuproptosis associated long non coding rna signature for the prognosis and immunotherapy of lung squamous cell carcinoma |
| topic | Lung squamous cell carcinoma cuproptosis long non-coding RNA prognosis immunotherapy |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/8481 |
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