Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry
Genetic variants in filaggrin (FLG) are key in eczema and are less common in Africans than in Europeans and Asians. Here we examined the association between FLG Single Nucleotide Polymorphisms (SNPs) and eczema in a population of admixed Brazilian children and whether African ancestry modifies this...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023008666 |
| _version_ | 1811161676903350272 |
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| author | Raimon Rios Thiago Magalhães da Silva Agostino Strina Erick Forno Ryan Costa Juan C. Celedón Maurício L. Barreto Camila Alexandrina Figueiredo |
| author_facet | Raimon Rios Thiago Magalhães da Silva Agostino Strina Erick Forno Ryan Costa Juan C. Celedón Maurício L. Barreto Camila Alexandrina Figueiredo |
| author_sort | Raimon Rios |
| collection | DOAJ |
| description | Genetic variants in filaggrin (FLG) are key in eczema and are less common in Africans than in Europeans and Asians. Here we examined the association between FLG Single Nucleotide Polymorphisms (SNPs) and eczema in a population of admixed Brazilian children and whether African ancestry modifies this association. We included 1010 controls and 137 cases and ran logistic regressions between SNPs in FLG and eczema in the studied population and also stratified the analyses according to the degree of African ancestry. In addition, we tested the replication of the findings on an independent set of individuals, as well as, we verified the impact on FLG expression according to each SNP genotype. The T allele of SNP rs6587666 was negatively associated with eczema in additive model (OR: 0.66, 95% CI: 0.47–0.93, P: 0.017). Moreover, African ancestry modifies the association between rs6587666 and eczema. The effect of the T allele was higher among individuals with higher African ancestry and the association with eczema was lost in individuals with lower African ancestry. In our analyses the expression of FLG in skin was slightly downregulated by the presence of the T allele of rs6587666. In our population, the T allele of rs6587666 in FLG was associated with protection to eczema and the degree of African ancestry was able to modify the observed association. |
| first_indexed | 2024-04-10T06:19:13Z |
| format | Article |
| id | doaj.art-28e148a1da914046bb9fd89e12bc4886 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T06:19:13Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-28e148a1da914046bb9fd89e12bc48862023-03-02T05:02:25ZengElsevierHeliyon2405-84402023-02-0192e13659Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestryRaimon Rios0Thiago Magalhães da Silva1Agostino Strina2Erick Forno3Ryan Costa4Juan C. Celedón5Maurício L. Barreto6Camila Alexandrina Figueiredo7Laboratory of Immunopharmacology and Molecular Biology, IMUNOBIO, Institute of Health Sciences, Federal University of Bahia, Salvador, BrazilBiological Sciences Department, State University of Southwestern Bahia, Jequié, Bahia, Brazil; Institute for Collective Health, Federal University of Bahia, Salvador, BrazilInstitute for Collective Health, Federal University of Bahia, Salvador, BrazilDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United StatesLaboratory of Immunopharmacology and Molecular Biology, IMUNOBIO, Institute of Health Sciences, Federal University of Bahia, Salvador, BrazilDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, United StatesInstitute for Collective Health, Federal University of Bahia, Salvador, Brazil; Center for Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Research Center, Fiocruz, Salvador, BrazilLaboratory of Immunopharmacology and Molecular Biology, IMUNOBIO, Institute of Health Sciences, Federal University of Bahia, Salvador, Brazil; Corresponding author. Departamento de Biorregulação, Laboratório de Imunofarmacologia e Biologia Molecular, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av. Reitor Miguel Calmon, s/n, CEP: 40.110-100, Canela, Salvador, Bahia, Brazil.Genetic variants in filaggrin (FLG) are key in eczema and are less common in Africans than in Europeans and Asians. Here we examined the association between FLG Single Nucleotide Polymorphisms (SNPs) and eczema in a population of admixed Brazilian children and whether African ancestry modifies this association. We included 1010 controls and 137 cases and ran logistic regressions between SNPs in FLG and eczema in the studied population and also stratified the analyses according to the degree of African ancestry. In addition, we tested the replication of the findings on an independent set of individuals, as well as, we verified the impact on FLG expression according to each SNP genotype. The T allele of SNP rs6587666 was negatively associated with eczema in additive model (OR: 0.66, 95% CI: 0.47–0.93, P: 0.017). Moreover, African ancestry modifies the association between rs6587666 and eczema. The effect of the T allele was higher among individuals with higher African ancestry and the association with eczema was lost in individuals with lower African ancestry. In our analyses the expression of FLG in skin was slightly downregulated by the presence of the T allele of rs6587666. In our population, the T allele of rs6587666 in FLG was associated with protection to eczema and the degree of African ancestry was able to modify the observed association.http://www.sciencedirect.com/science/article/pii/S2405844023008666FilaggrinFLGAtopic dermatitisSkinAllele |
| spellingShingle | Raimon Rios Thiago Magalhães da Silva Agostino Strina Erick Forno Ryan Costa Juan C. Celedón Maurício L. Barreto Camila Alexandrina Figueiredo Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry Heliyon Filaggrin FLG Atopic dermatitis Skin Allele |
| title | Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry |
| title_full | Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry |
| title_fullStr | Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry |
| title_full_unstemmed | Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry |
| title_short | Genetic polymorphism (rs6587666) in FLG protects from eczema in admixed Brazilian children population with high African ancestry |
| title_sort | genetic polymorphism rs6587666 in flg protects from eczema in admixed brazilian children population with high african ancestry |
| topic | Filaggrin FLG Atopic dermatitis Skin Allele |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023008666 |
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