Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer
Signal transducer and activator of transcription 3 (STAT3) functions as a major molecular switch that plays an important role in the communication between cytokines and kinases. In this role, it regulates the transcription of genes involved in various biochemical processes, such as proliferation, mi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2202 |
| _version_ | 1797416566566944768 |
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| author | Kyung-Soo Chun Jeong-Hoon Jang Do-Hee Kim |
| author_facet | Kyung-Soo Chun Jeong-Hoon Jang Do-Hee Kim |
| author_sort | Kyung-Soo Chun |
| collection | DOAJ |
| description | Signal transducer and activator of transcription 3 (STAT3) functions as a major molecular switch that plays an important role in the communication between cytokines and kinases. In this role, it regulates the transcription of genes involved in various biochemical processes, such as proliferation, migration, and metabolism of cancer cells. STAT3 undergoes diverse post-translational modifications, such as the oxidation of cysteine by oxidative stress, the acetylation of lysine, or the phosphorylation of serine/threonine. In particular, the redox modulation of critical cysteine residues present in the DNA-binding domain of STAT3 inhibits its DNA-binding activity, resulting in the inactivation of STAT3-mediated gene expression. Accumulating evidence supports that STAT3 is a key protein that acts as a mediator of metabolism and mitochondrial activity. In this review, we focus on the post-translational modifications of STAT3 by oxidative stress and how the modification of STAT3 regulates cell metabolism, particularly in the metabolic pathways in cancer cells. |
| first_indexed | 2024-03-09T06:05:06Z |
| format | Article |
| id | doaj.art-28e2be40418a43529a9f42344828fd14 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T06:05:06Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-28e2be40418a43529a9f42344828fd142023-12-03T12:04:06ZengMDPI AGCells2073-44092020-09-01910220210.3390/cells9102202Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in CancerKyung-Soo Chun0Jeong-Hoon Jang1Do-Hee Kim2College of Pharmacy, Keimyung University, Daegu 42601, KoreaTumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul 08826, KoreaDepartment of Chemistry, College of Convergence and Integrated Science, Kyonggi University, Suwon, Gyonggi-do 16277, KoreaSignal transducer and activator of transcription 3 (STAT3) functions as a major molecular switch that plays an important role in the communication between cytokines and kinases. In this role, it regulates the transcription of genes involved in various biochemical processes, such as proliferation, migration, and metabolism of cancer cells. STAT3 undergoes diverse post-translational modifications, such as the oxidation of cysteine by oxidative stress, the acetylation of lysine, or the phosphorylation of serine/threonine. In particular, the redox modulation of critical cysteine residues present in the DNA-binding domain of STAT3 inhibits its DNA-binding activity, resulting in the inactivation of STAT3-mediated gene expression. Accumulating evidence supports that STAT3 is a key protein that acts as a mediator of metabolism and mitochondrial activity. In this review, we focus on the post-translational modifications of STAT3 by oxidative stress and how the modification of STAT3 regulates cell metabolism, particularly in the metabolic pathways in cancer cells.https://www.mdpi.com/2073-4409/9/10/2202STAT3cancer metabolismpost-translational modificationmitochondriaredox regulationoxidative stress |
| spellingShingle | Kyung-Soo Chun Jeong-Hoon Jang Do-Hee Kim Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer Cells STAT3 cancer metabolism post-translational modification mitochondria redox regulation oxidative stress |
| title | Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer |
| title_full | Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer |
| title_fullStr | Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer |
| title_full_unstemmed | Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer |
| title_short | Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer |
| title_sort | perspectives regarding the intersections between stat3 and oxidative metabolism in cancer |
| topic | STAT3 cancer metabolism post-translational modification mitochondria redox regulation oxidative stress |
| url | https://www.mdpi.com/2073-4409/9/10/2202 |
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