Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life
Asthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-world study investigated whether phenotyping patients with asthma...
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| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/11/1684 |
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| author | Fabio Luigi Massimo Ricciardolo Andrea Elio Sprio Andrea Baroso Fabio Gallo Elisa Riccardi Francesca Bertolini Vitina Carriero Elisa Arrigo Giorgio Ciprandi |
| author_facet | Fabio Luigi Massimo Ricciardolo Andrea Elio Sprio Andrea Baroso Fabio Gallo Elisa Riccardi Francesca Bertolini Vitina Carriero Elisa Arrigo Giorgio Ciprandi |
| author_sort | Fabio Luigi Massimo Ricciardolo |
| collection | DOAJ |
| description | Asthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-world study investigated whether phenotyping patients with asthma using non-invasive parameters could be feasible to characterize the T2-low and T2-high asthma phenotypes in clinical practice. This cross-sectional observational study involved asthmatic outpatients (<i>n</i> = 503) referring to the Severe Asthma Centre of the San Luigi Gonzaga University Hospital. Participants were stratified according to the patterns of T2 inflammation and atopic sensitization. Among outpatients, 98 (19.5%) patients had T2-low asthma, 127 (25.2%) T2-high non-allergic, and 278 (55.3%) had T2-high allergic phenotype. In comparison to T2-low, allergic patients were younger (OR 0.945, <i>p</i> < 0.001) and thinner (OR 0.913, <i>p</i> < 0.001), had lower smoke exposure (OR 0.975, <i>p</i> < 0.001) and RV/TLC% (OR 0.950, <i>p</i> < 0.001), higher prevalence of asthma severity grade 5 (OR 2.236, <i>p</i> < 0.05), more frequent rhinitis (OR 3.491, <i>p</i> < 0.001) and chronic rhinosinusitis with (OR 2.650, <i>p</i> < 0.001) or without (OR 1.919, <i>p</i> < 0.05) nasal polyps, but less common arterial hypertension (OR 0.331, <i>p</i> < 0.001). T2-high non-allergic patients had intermediate characteristics. Non-invasive phenotyping of asthmatic patients is possible in clinical practice. Identifying characteristics in the three main asthma phenotypes could pave the way for further investigations on useful biomarkers for precision medicine. |
| first_indexed | 2024-03-10T05:40:58Z |
| format | Article |
| id | doaj.art-28e396e52d32412b85e279670b83542d |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T05:40:58Z |
| publishDate | 2021-11-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-28e396e52d32412b85e279670b83542d2023-11-22T22:31:54ZengMDPI AGBiomedicines2227-90592021-11-01911168410.3390/biomedicines9111684Characterization of T2-Low and T2-High Asthma Phenotypes in Real-LifeFabio Luigi Massimo Ricciardolo0Andrea Elio Sprio1Andrea Baroso2Fabio Gallo3Elisa Riccardi4Francesca Bertolini5Vitina Carriero6Elisa Arrigo7Giorgio Ciprandi8Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyClinical Epidemiology Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyDepartment of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga University Hospital, 10043 Turin, ItalyAllergy Clinic, Casa di Cura Villa Montallegro, 16145 Genoa, ItalyAsthma is a heterogeneous and complex condition characterized by chronic airway inflammation, which may be clinically stratified into three main phenotypes: type 2 (T2) low, T2-high allergic, and T2-high non-allergic asthma. This real-world study investigated whether phenotyping patients with asthma using non-invasive parameters could be feasible to characterize the T2-low and T2-high asthma phenotypes in clinical practice. This cross-sectional observational study involved asthmatic outpatients (<i>n</i> = 503) referring to the Severe Asthma Centre of the San Luigi Gonzaga University Hospital. Participants were stratified according to the patterns of T2 inflammation and atopic sensitization. Among outpatients, 98 (19.5%) patients had T2-low asthma, 127 (25.2%) T2-high non-allergic, and 278 (55.3%) had T2-high allergic phenotype. In comparison to T2-low, allergic patients were younger (OR 0.945, <i>p</i> < 0.001) and thinner (OR 0.913, <i>p</i> < 0.001), had lower smoke exposure (OR 0.975, <i>p</i> < 0.001) and RV/TLC% (OR 0.950, <i>p</i> < 0.001), higher prevalence of asthma severity grade 5 (OR 2.236, <i>p</i> < 0.05), more frequent rhinitis (OR 3.491, <i>p</i> < 0.001) and chronic rhinosinusitis with (OR 2.650, <i>p</i> < 0.001) or without (OR 1.919, <i>p</i> < 0.05) nasal polyps, but less common arterial hypertension (OR 0.331, <i>p</i> < 0.001). T2-high non-allergic patients had intermediate characteristics. Non-invasive phenotyping of asthmatic patients is possible in clinical practice. Identifying characteristics in the three main asthma phenotypes could pave the way for further investigations on useful biomarkers for precision medicine.https://www.mdpi.com/2227-9059/9/11/1684asthmainflammationasthma phenotypesreal-worldclinical practiceT2 low |
| spellingShingle | Fabio Luigi Massimo Ricciardolo Andrea Elio Sprio Andrea Baroso Fabio Gallo Elisa Riccardi Francesca Bertolini Vitina Carriero Elisa Arrigo Giorgio Ciprandi Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life Biomedicines asthma inflammation asthma phenotypes real-world clinical practice T2 low |
| title | Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life |
| title_full | Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life |
| title_fullStr | Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life |
| title_full_unstemmed | Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life |
| title_short | Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life |
| title_sort | characterization of t2 low and t2 high asthma phenotypes in real life |
| topic | asthma inflammation asthma phenotypes real-world clinical practice T2 low |
| url | https://www.mdpi.com/2227-9059/9/11/1684 |
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