Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center
ABSTRACT Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtaine...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colégio Brasileiro de Cirurgiões
2021-02-01
|
| Series: | Revista do Colégio Brasileiro de Cirurgiões |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206&tlng=pt |
| _version_ | 1819008692638449664 |
|---|---|
| author | RAPHAELLA PAULA FERREIRA DANILO SAAVEDRA BUSSYGUIN HYGOR TROMBETTA VICTOR JOSE DORNELAS MELO DANIELE REZENDE XIMENEZ VINICIUS BASSO PRETI GERARDO CRISTINO GAVARRETE VALLADARES FLAVIO DANIEL SAAVEDRA TOMASICH PHILLIPE ABREU |
| author_facet | RAPHAELLA PAULA FERREIRA DANILO SAAVEDRA BUSSYGUIN HYGOR TROMBETTA VICTOR JOSE DORNELAS MELO DANIELE REZENDE XIMENEZ VINICIUS BASSO PRETI GERARDO CRISTINO GAVARRETE VALLADARES FLAVIO DANIEL SAAVEDRA TOMASICH PHILLIPE ABREU |
| author_sort | RAPHAELLA PAULA FERREIRA |
| collection | DOAJ |
| description | ABSTRACT Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtained by the Division of Surgical Oncology of Erasto Gaertner Hospital. The sample was divided into Period 1 (1987-1997), Period 2 (1998-2003) and Period 3 (2007-2015). Survival rates and disease-free survival were estimated by the Kaplan-Maier method. Survival predictors were identified with Cox regression. ANOVA test was used for comparison between groups. Data were analyzed with SPSS 25.0 and STATA 16, and p<0.05 was considered statistically significant. Results: a total of 335 patients underwent esophagectomy or esophagogastrectomy. When the clinical characteristics of the 3 groups were compared, there was no statistically significant difference. Neoadjuvance was significantly higher in Period 3 (55.4% of patients). We found a histological change in the diagnosis over time, with a significant increase in adenocarcinoma. Morbidity and mortality rates were higher in Period 3. The main complications were pulmonary and anastomotic fistulas. Overall survival in 5 years increased over time, reaching 59.7% in Period 3. Conclusions: better neoadjuvant treatment contributed to increase the global survival of patients, despite greater rate of immediate complications to surgery. |
| first_indexed | 2024-12-21T00:44:31Z |
| format | Article |
| id | doaj.art-28e404ebbfb14792b1bfd23121cc4ff9 |
| institution | Directory Open Access Journal |
| issn | 1809-4546 |
| language | English |
| last_indexed | 2024-12-21T00:44:31Z |
| publishDate | 2021-02-01 |
| publisher | Colégio Brasileiro de Cirurgiões |
| record_format | Article |
| series | Revista do Colégio Brasileiro de Cirurgiões |
| spelling | doaj.art-28e404ebbfb14792b1bfd23121cc4ff92022-12-21T19:21:34ZengColégio Brasileiro de CirurgiõesRevista do Colégio Brasileiro de Cirurgiões1809-45462021-02-014810.1590/0100-6991e-20202723Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single centerRAPHAELLA PAULA FERREIRADANILO SAAVEDRA BUSSYGUINHYGOR TROMBETTAVICTOR JOSE DORNELAS MELODANIELE REZENDE XIMENEZVINICIUS BASSO PRETIGERARDO CRISTINO GAVARRETE VALLADARESFLAVIO DANIEL SAAVEDRA TOMASICHPHILLIPE ABREUhttps://orcid.org/0000-0001-6340-7738ABSTRACT Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtained by the Division of Surgical Oncology of Erasto Gaertner Hospital. The sample was divided into Period 1 (1987-1997), Period 2 (1998-2003) and Period 3 (2007-2015). Survival rates and disease-free survival were estimated by the Kaplan-Maier method. Survival predictors were identified with Cox regression. ANOVA test was used for comparison between groups. Data were analyzed with SPSS 25.0 and STATA 16, and p<0.05 was considered statistically significant. Results: a total of 335 patients underwent esophagectomy or esophagogastrectomy. When the clinical characteristics of the 3 groups were compared, there was no statistically significant difference. Neoadjuvance was significantly higher in Period 3 (55.4% of patients). We found a histological change in the diagnosis over time, with a significant increase in adenocarcinoma. Morbidity and mortality rates were higher in Period 3. The main complications were pulmonary and anastomotic fistulas. Overall survival in 5 years increased over time, reaching 59.7% in Period 3. Conclusions: better neoadjuvant treatment contributed to increase the global survival of patients, despite greater rate of immediate complications to surgery.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206&tlng=ptEsophageal NeoplasmsEsophagectomyPostoperative ComplicationsTreatment Outcome |
| spellingShingle | RAPHAELLA PAULA FERREIRA DANILO SAAVEDRA BUSSYGUIN HYGOR TROMBETTA VICTOR JOSE DORNELAS MELO DANIELE REZENDE XIMENEZ VINICIUS BASSO PRETI GERARDO CRISTINO GAVARRETE VALLADARES FLAVIO DANIEL SAAVEDRA TOMASICH PHILLIPE ABREU Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center Revista do Colégio Brasileiro de Cirurgiões Esophageal Neoplasms Esophagectomy Postoperative Complications Treatment Outcome |
| title | Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
| title_full | Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
| title_fullStr | Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
| title_full_unstemmed | Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
| title_short | Treatment of esophageal cancer: surgical outcomes of 335 cases operated in a single center |
| title_sort | treatment of esophageal cancer surgical outcomes of 335 cases operated in a single center |
| topic | Esophageal Neoplasms Esophagectomy Postoperative Complications Treatment Outcome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912021000100206&tlng=pt |
| work_keys_str_mv | AT raphaellapaulaferreira treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT danilosaavedrabussyguin treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT hygortrombetta treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT victorjosedornelasmelo treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT danielerezendeximenez treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT viniciusbassopreti treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT gerardocristinogavarretevalladares treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT flaviodanielsaavedratomasich treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter AT phillipeabreu treatmentofesophagealcancersurgicaloutcomesof335casesoperatedinasinglecenter |