Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy
PURPOSE: Preexisting bone loss in men with prostate cancer is an important issue due to the accelerated bone loss during androgen deprivation therapy (ADT). In addition, a high prostate-specific antigen (PSA) level has been reported to be related to bone metabolism. This study assessed the factors a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Urologia
2009-04-01
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| Series: | International Brazilian Journal of Urology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382009000200008 |
| _version_ | 1818923772165488640 |
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| author | Sun-Ouck Kim Taek Won Kang Dongdeuk Kwon Kwangsung Park Soo Bang Ryu |
| author_facet | Sun-Ouck Kim Taek Won Kang Dongdeuk Kwon Kwangsung Park Soo Bang Ryu |
| author_sort | Sun-Ouck Kim |
| collection | DOAJ |
| description | PURPOSE: Preexisting bone loss in men with prostate cancer is an important issue due to the accelerated bone loss during androgen deprivation therapy (ADT). In addition, a high prostate-specific antigen (PSA) level has been reported to be related to bone metabolism. This study assessed the factors associated with osteoporosis in Korean men with non-metastatic prostate cancer before undergoing ADT. MATERIAL AND METHODS: The study enrolled patients admitted for a prostate biopsy because of a high PSA or palpable nodule on a digital rectal examination. We divided the patients (n = 172) according to the results of the biopsy: group I, non-metastatic prostate cancer (n = 42) and group II, benign prostatic hypertrophy (BPH; n = 130). The lumbar bone mineral density (BMD) was evaluated using quantitative computed tomography. The demographic, health status, lifestyle, body mass index (BMI), serum testosterone concentration, and disease variables in prostate cancer (Gleason score, clinical stage, and PSA) were analyzed prospectively to determine their effect on the BMD. RESULTS: The estimated mean T-score was higher in group I than in group II (-1.96 ± 3.35 vs. -2.66 ± 3.20), but without statistic significance (p = 0.235). The significant factors correlated with BMD in group I were a high serum PSA (ß = -0.346, p = 0.010) and low BMI (ß = 0.345, p = 0.014) in the multiple linear regression model. Also old age (r = -0.481, p = 0.001), a high serum PSA (r = -0.571, p < 0.001), low BMI (r = 0.598, p < 0.001), and a high Gleason’s score (r = -0.319, p = 0.040) were the factors related to BMD in the correlation. The significant factors correlated with BMD in group II were old age (ß = -0.324, p = 0.001) and BMI (ß = 0.143, p = 0.014) in the multiple linear regression model. CONCLUSIONS: The risk factors for osteoporosis in men with prostate cancer include a low BMI, and elevated serum PSA. Monitoring BMD from the outset of ADT is a logical first step in the clinical strategy to avoid or minimize potential bone-related complications in these patients. |
| first_indexed | 2024-12-20T02:14:44Z |
| format | Article |
| id | doaj.art-28e79061b93043d8881c75108bd582b2 |
| institution | Directory Open Access Journal |
| issn | 1677-5538 1677-6119 |
| language | English |
| last_indexed | 2024-12-20T02:14:44Z |
| publishDate | 2009-04-01 |
| publisher | Sociedade Brasileira de Urologia |
| record_format | Article |
| series | International Brazilian Journal of Urology |
| spelling | doaj.art-28e79061b93043d8881c75108bd582b22022-12-21T19:56:58ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192009-04-0135218318910.1590/S1677-55382009000200008Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapySun-Ouck KimTaek Won KangDongdeuk KwonKwangsung ParkSoo Bang RyuPURPOSE: Preexisting bone loss in men with prostate cancer is an important issue due to the accelerated bone loss during androgen deprivation therapy (ADT). In addition, a high prostate-specific antigen (PSA) level has been reported to be related to bone metabolism. This study assessed the factors associated with osteoporosis in Korean men with non-metastatic prostate cancer before undergoing ADT. MATERIAL AND METHODS: The study enrolled patients admitted for a prostate biopsy because of a high PSA or palpable nodule on a digital rectal examination. We divided the patients (n = 172) according to the results of the biopsy: group I, non-metastatic prostate cancer (n = 42) and group II, benign prostatic hypertrophy (BPH; n = 130). The lumbar bone mineral density (BMD) was evaluated using quantitative computed tomography. The demographic, health status, lifestyle, body mass index (BMI), serum testosterone concentration, and disease variables in prostate cancer (Gleason score, clinical stage, and PSA) were analyzed prospectively to determine their effect on the BMD. RESULTS: The estimated mean T-score was higher in group I than in group II (-1.96 ± 3.35 vs. -2.66 ± 3.20), but without statistic significance (p = 0.235). The significant factors correlated with BMD in group I were a high serum PSA (ß = -0.346, p = 0.010) and low BMI (ß = 0.345, p = 0.014) in the multiple linear regression model. Also old age (r = -0.481, p = 0.001), a high serum PSA (r = -0.571, p < 0.001), low BMI (r = 0.598, p < 0.001), and a high Gleason’s score (r = -0.319, p = 0.040) were the factors related to BMD in the correlation. The significant factors correlated with BMD in group II were old age (ß = -0.324, p = 0.001) and BMI (ß = 0.143, p = 0.014) in the multiple linear regression model. CONCLUSIONS: The risk factors for osteoporosis in men with prostate cancer include a low BMI, and elevated serum PSA. Monitoring BMD from the outset of ADT is a logical first step in the clinical strategy to avoid or minimize potential bone-related complications in these patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382009000200008prostate neoplasmosteoporosisandrogen deprivation therapyprostate specific antigen |
| spellingShingle | Sun-Ouck Kim Taek Won Kang Dongdeuk Kwon Kwangsung Park Soo Bang Ryu Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy International Brazilian Journal of Urology prostate neoplasm osteoporosis androgen deprivation therapy prostate specific antigen |
| title | Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy |
| title_full | Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy |
| title_fullStr | Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy |
| title_full_unstemmed | Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy |
| title_short | Risk factors for bone loss with prostate cancer in Korean men not receiving androgen deprivation therapy |
| title_sort | risk factors for bone loss with prostate cancer in korean men not receiving androgen deprivation therapy |
| topic | prostate neoplasm osteoporosis androgen deprivation therapy prostate specific antigen |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382009000200008 |
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