Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC
Background: Jatamansi/Nardostachys jatamansi (NJ) is an important aromatic shrub widely used by Ayurvedic practitioners for centuries due to its usefulness in intellect-enhancing (Medhya), strengthening (Balya), and skin disorders. Several classical dosage forms like hot or cold infusion, decoction,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947624000159 |
| _version_ | 1797234320340942848 |
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| author | Sandeep Chavan Bhagwan Vidya Shrikant Gupta Vineeta Vasant Deshmukh Sukumar Sadanand Sardeshmukh Sadanand Prabhakar Sardeshmukh |
| author_facet | Sandeep Chavan Bhagwan Vidya Shrikant Gupta Vineeta Vasant Deshmukh Sukumar Sadanand Sardeshmukh Sadanand Prabhakar Sardeshmukh |
| author_sort | Sandeep Chavan Bhagwan |
| collection | DOAJ |
| description | Background: Jatamansi/Nardostachys jatamansi (NJ) is an important aromatic shrub widely used by Ayurvedic practitioners for centuries due to its usefulness in intellect-enhancing (Medhya), strengthening (Balya), and skin disorders. Several classical dosage forms like hot or cold infusion, decoction, distillate, powders, etc. have been mentioned for NJ. Clinical trials of Jatamansi Oil (JO) as a head massage conducted by clinicians and therapists have shown encouraging results in de-stressing/stress management of cancer patients through head anointing treatment. Objective: Such effective proprietary formulation needs assessment of its characteristics using modern analytical technologies to comprehend the Ayurvedic concept of dermal pharmacology. Materials and methods: Triplicate batches of JO were prepared by evaporating its decoction in sesame oil (SO). Basic physicochemical analysis of the raw material, in-process samples, and finished products was carried out to develop a monograph. Further, raw SO and finished product JO were subjected to TLC, and extracted in hexane and dichloromethane separately for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to profile several bioactive molecules from NJ in the final product, JO. Results: Standard Operating Procedure was developed and a basic monograph was prepared for JO. GC-MS analysis revealed several phytocompounds dissolved/dispersed in SO after processing, while 18 additional distinct peaks were observed in JO as compared to SO. Conclusion: This preliminary analysis supports the Ayurvedic concept of lipid-based formulations. The plausible phytocompounds anticipated based on retention times can be further quantified and studied for their probable action as anointing treatment. A detailed experimental strategy for understanding the phytochemical changes during the entire process needs to be planned and performed. |
| first_indexed | 2024-04-24T16:30:11Z |
| format | Article |
| id | doaj.art-28e7f717cd3a41dca7c2572090a75434 |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-04-24T16:30:11Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-28e7f717cd3a41dca7c2572090a754342024-03-30T04:38:46ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762024-03-01152100900Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DCSandeep Chavan Bhagwan0Vidya Shrikant Gupta1Vineeta Vasant Deshmukh2Sukumar Sadanand Sardeshmukh3Sadanand Prabhakar Sardeshmukh4Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India; Atharva Nature Healthcare Pvt Ltd, Wagholi, Pune, 412 207, India; Corresponding author. Gat No. 676, Kesnand Road, Wagholi, Pune, 412207, Maharashtra, India.Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India; Atharva Nature Healthcare Pvt Ltd, Wagholi, Pune, 412 207, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India; Atharva Nature Healthcare Pvt Ltd, Wagholi, Pune, 412 207, IndiaBackground: Jatamansi/Nardostachys jatamansi (NJ) is an important aromatic shrub widely used by Ayurvedic practitioners for centuries due to its usefulness in intellect-enhancing (Medhya), strengthening (Balya), and skin disorders. Several classical dosage forms like hot or cold infusion, decoction, distillate, powders, etc. have been mentioned for NJ. Clinical trials of Jatamansi Oil (JO) as a head massage conducted by clinicians and therapists have shown encouraging results in de-stressing/stress management of cancer patients through head anointing treatment. Objective: Such effective proprietary formulation needs assessment of its characteristics using modern analytical technologies to comprehend the Ayurvedic concept of dermal pharmacology. Materials and methods: Triplicate batches of JO were prepared by evaporating its decoction in sesame oil (SO). Basic physicochemical analysis of the raw material, in-process samples, and finished products was carried out to develop a monograph. Further, raw SO and finished product JO were subjected to TLC, and extracted in hexane and dichloromethane separately for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to profile several bioactive molecules from NJ in the final product, JO. Results: Standard Operating Procedure was developed and a basic monograph was prepared for JO. GC-MS analysis revealed several phytocompounds dissolved/dispersed in SO after processing, while 18 additional distinct peaks were observed in JO as compared to SO. Conclusion: This preliminary analysis supports the Ayurvedic concept of lipid-based formulations. The plausible phytocompounds anticipated based on retention times can be further quantified and studied for their probable action as anointing treatment. A detailed experimental strategy for understanding the phytochemical changes during the entire process needs to be planned and performed.http://www.sciencedirect.com/science/article/pii/S0975947624000159CharacterizationGas chromatographyJatamansi oilMass SpectrometryMedicated oilMonograph |
| spellingShingle | Sandeep Chavan Bhagwan Vidya Shrikant Gupta Vineeta Vasant Deshmukh Sukumar Sadanand Sardeshmukh Sadanand Prabhakar Sardeshmukh Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC Journal of Ayurveda and Integrative Medicine Characterization Gas chromatography Jatamansi oil Mass Spectrometry Medicated oil Monograph |
| title | Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC |
| title_full | Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC |
| title_fullStr | Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC |
| title_full_unstemmed | Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC |
| title_short | Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC |
| title_sort | standardization and preliminary characterization of an ayurvedic stress relieving head massage oil of nardostachys jatamansi dc |
| topic | Characterization Gas chromatography Jatamansi oil Mass Spectrometry Medicated oil Monograph |
| url | http://www.sciencedirect.com/science/article/pii/S0975947624000159 |
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