Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt
A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2013-06-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093112000300 |
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| author | Camilia Michel Moshera El-sherei Wafaa Islam Amani Sleem Shaimaa Ahmed |
| author_facet | Camilia Michel Moshera El-sherei Wafaa Islam Amani Sleem Shaimaa Ahmed |
| author_sort | Camilia Michel |
| collection | DOAJ |
| description | A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and indomethacin (20 mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data. |
| first_indexed | 2024-04-11T03:26:38Z |
| format | Article |
| id | doaj.art-28e810f10e4d4577935a82ac72265be3 |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T03:26:38Z |
| publishDate | 2013-06-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-28e810f10e4d4577935a82ac72265be32023-01-02T07:16:08ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312013-06-015111510.1016/j.bfopcu.2012.07.003Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in EgyptCamilia Michel0Moshera El-sherei1Wafaa Islam2Amani Sleem3Shaimaa Ahmed4Faculty of Pharmacy, Pharmacognosy Department, Cairo University, EgyptFaculty of Pharmacy, Pharmacognosy Department, Cairo University, EgyptFaculty of Pharmacy, Pharmacognosy Department, Cairo University, EgyptNational Research Center, Pharmacology Department, Dokki, Giza, EgyptFaculty of Pharmacy, Pharmacognosy Department, Cairo University, EgyptA bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and indomethacin (20 mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data.http://www.sciencedirect.com/science/article/pii/S1110093112000300Pterocarpus dalbergioidesStem barkAntihyperglycemicAnti-inflammatory |
| spellingShingle | Camilia Michel Moshera El-sherei Wafaa Islam Amani Sleem Shaimaa Ahmed Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt Bulletin of Faculty of Pharmacy Cairo University Pterocarpus dalbergioides Stem bark Antihyperglycemic Anti-inflammatory |
| title | Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt |
| title_full | Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt |
| title_fullStr | Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt |
| title_full_unstemmed | Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt |
| title_short | Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt |
| title_sort | bioactivity guided fractionation of the stem bark extract of pterocarpus dalbergioides roxb ex dc growing in egypt |
| topic | Pterocarpus dalbergioides Stem bark Antihyperglycemic Anti-inflammatory |
| url | http://www.sciencedirect.com/science/article/pii/S1110093112000300 |
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