MUC14-Related ncRNA-mRNA Network in Breast Cancer
<b>Abstract</b>: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. <b>Methods:&l...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/11/1677 |
| _version_ | 1797510206166401024 |
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| author | Shuqian Wang Jing Jin Jing Chen Weiyang Lou |
| author_facet | Shuqian Wang Jing Jin Jing Chen Weiyang Lou |
| author_sort | Shuqian Wang |
| collection | DOAJ |
| description | <b>Abstract</b>: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. <b>Methods:</b> A series of in silico analyses were employed in this study. <b>Results:</b> After performing comprehensive analysis for MUCs, MUC14 was identified as the most potential regulator in breast cancer, with downregulated expression in both mRNA and protein levels and significant diagnostic and prognostic values in breast cancer. Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/miR-429-BCL2, might be partially responsible for MUC14′s functions in breast cancer. <b>Conclusions:</b> Collectively, our study elucidated a key role of MUC14 in breast cancer and also provided some clues for explanation of the molecular action mechanism of MUC14 in breast cancer. |
| first_indexed | 2024-03-10T05:28:18Z |
| format | Article |
| id | doaj.art-28e9886c578b4fd28e3fc54af20efe35 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T05:28:18Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-28e9886c578b4fd28e3fc54af20efe352023-11-22T23:27:09ZengMDPI AGGenes2073-44252021-10-011211167710.3390/genes12111677MUC14-Related ncRNA-mRNA Network in Breast CancerShuqian Wang0Jing Jin1Jing Chen2Weiyang Lou3Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Oncology, The First Affiliated Hospital of Jiaxing University, Jiaxing 314000, ChinaDepartment of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China<b>Abstract</b>: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. <b>Methods:</b> A series of in silico analyses were employed in this study. <b>Results:</b> After performing comprehensive analysis for MUCs, MUC14 was identified as the most potential regulator in breast cancer, with downregulated expression in both mRNA and protein levels and significant diagnostic and prognostic values in breast cancer. Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/miR-429-BCL2, might be partially responsible for MUC14′s functions in breast cancer. <b>Conclusions:</b> Collectively, our study elucidated a key role of MUC14 in breast cancer and also provided some clues for explanation of the molecular action mechanism of MUC14 in breast cancer.https://www.mdpi.com/2073-4425/12/11/1677mucin 14 (MUC14)noncoding RNA (ncRNA)microRNA (miRNA)breast cancerbioinformatic analysis |
| spellingShingle | Shuqian Wang Jing Jin Jing Chen Weiyang Lou MUC14-Related ncRNA-mRNA Network in Breast Cancer Genes mucin 14 (MUC14) noncoding RNA (ncRNA) microRNA (miRNA) breast cancer bioinformatic analysis |
| title | MUC14-Related ncRNA-mRNA Network in Breast Cancer |
| title_full | MUC14-Related ncRNA-mRNA Network in Breast Cancer |
| title_fullStr | MUC14-Related ncRNA-mRNA Network in Breast Cancer |
| title_full_unstemmed | MUC14-Related ncRNA-mRNA Network in Breast Cancer |
| title_short | MUC14-Related ncRNA-mRNA Network in Breast Cancer |
| title_sort | muc14 related ncrna mrna network in breast cancer |
| topic | mucin 14 (MUC14) noncoding RNA (ncRNA) microRNA (miRNA) breast cancer bioinformatic analysis |
| url | https://www.mdpi.com/2073-4425/12/11/1677 |
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