Advances in Cardiovascular Biomarker Discovery
Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart failure and stroke. Identifying novel and early stage biomarkers of hypertension...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/8/12/552 |
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| author | Crystal M. Ghantous Layla Kamareddine Rima Farhat Fouad A. Zouein Stefania Mondello Firas Kobeissy Asad Zeidan |
| author_facet | Crystal M. Ghantous Layla Kamareddine Rima Farhat Fouad A. Zouein Stefania Mondello Firas Kobeissy Asad Zeidan |
| author_sort | Crystal M. Ghantous |
| collection | DOAJ |
| description | Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart failure and stroke. Identifying novel and early stage biomarkers of hypertension and other cardiovascular diseases is of paramount importance in predicting and preventing the major morbidity and mortality associated with these diseases. Biomarkers of such diseases or predisposition to their development are identified by changes in a specific indicator’s expression between healthy individuals and patients. These include changes in protein and microRNA (miRNA) levels. Protein profiling using mass spectrometry and miRNA screening utilizing microarray and sequencing have facilitated the discovery of proteins and miRNA as biomarker candidates. In this review, we summarized some of the different, promising early stage protein and miRNA biomarker candidates as well as the currently used biomarkers for hypertension and other cardiovascular diseases. Although a number of promising markers have been identified, it is unlikely that a single biomarker will unambiguously aid in the classification of these diseases. A multi-marker panel-strategy appears useful and promising for classifying and refining risk stratification among patients with cardiovascular disease. |
| first_indexed | 2024-03-10T14:26:53Z |
| format | Article |
| id | doaj.art-28e9cae0838648d79413de341aa069c3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T14:26:53Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-28e9cae0838648d79413de341aa069c32023-11-20T22:54:05ZengMDPI AGBiomedicines2227-90592020-11-0181255210.3390/biomedicines8120552Advances in Cardiovascular Biomarker DiscoveryCrystal M. Ghantous0Layla Kamareddine1Rima Farhat2Fouad A. Zouein3Stefania Mondello4Firas Kobeissy5Asad Zeidan6Department of Nursing and Health Sciences, Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Keserwan 72, LebanonBiomedical Sciences Department, College of Health Sciences, QU Health, Qatar University, Doha 2713, QatarDepartment of Anatomy, Cell Biology and Physiology, Faculty of Medicine, American University of Beirut, Beirut 1107, LebanonDepartment of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut 1107, LebanonOasi Research Institute-IRCCS, 94018 Troina, ItalyDepartment of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut 1107, LebanonBiomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha 2713, QatarCardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart failure and stroke. Identifying novel and early stage biomarkers of hypertension and other cardiovascular diseases is of paramount importance in predicting and preventing the major morbidity and mortality associated with these diseases. Biomarkers of such diseases or predisposition to their development are identified by changes in a specific indicator’s expression between healthy individuals and patients. These include changes in protein and microRNA (miRNA) levels. Protein profiling using mass spectrometry and miRNA screening utilizing microarray and sequencing have facilitated the discovery of proteins and miRNA as biomarker candidates. In this review, we summarized some of the different, promising early stage protein and miRNA biomarker candidates as well as the currently used biomarkers for hypertension and other cardiovascular diseases. Although a number of promising markers have been identified, it is unlikely that a single biomarker will unambiguously aid in the classification of these diseases. A multi-marker panel-strategy appears useful and promising for classifying and refining risk stratification among patients with cardiovascular disease.https://www.mdpi.com/2227-9059/8/12/552biomarkerscardiovascular diseaseshypertensionproteomicsmiRNA |
| spellingShingle | Crystal M. Ghantous Layla Kamareddine Rima Farhat Fouad A. Zouein Stefania Mondello Firas Kobeissy Asad Zeidan Advances in Cardiovascular Biomarker Discovery Biomedicines biomarkers cardiovascular diseases hypertension proteomics miRNA |
| title | Advances in Cardiovascular Biomarker Discovery |
| title_full | Advances in Cardiovascular Biomarker Discovery |
| title_fullStr | Advances in Cardiovascular Biomarker Discovery |
| title_full_unstemmed | Advances in Cardiovascular Biomarker Discovery |
| title_short | Advances in Cardiovascular Biomarker Discovery |
| title_sort | advances in cardiovascular biomarker discovery |
| topic | biomarkers cardiovascular diseases hypertension proteomics miRNA |
| url | https://www.mdpi.com/2227-9059/8/12/552 |
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