Characteristics of sarcopenia by European consensuses and a phenotype score
Abstract Background We aimed to assess the clinical characteristics of sarcopenia by the original and revised European Working Group on Sarcopenia in Older People (EWGSOP 1 and 2), and to propose a new sarcopenia phenotype score (SPS) to improve relevance of clinical outcomes. Methods Analyses were...
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
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| Online Access: | https://doi.org/10.1002/jcsm.12507 |
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| author | Il‐Young Jang Eunju Lee Heayon Lee Hyungchul Park Sunyoung Kim Kwang‐il Kim Hee‐Won Jung Dae Hyun Kim |
| author_facet | Il‐Young Jang Eunju Lee Heayon Lee Hyungchul Park Sunyoung Kim Kwang‐il Kim Hee‐Won Jung Dae Hyun Kim |
| author_sort | Il‐Young Jang |
| collection | DOAJ |
| description | Abstract Background We aimed to assess the clinical characteristics of sarcopenia by the original and revised European Working Group on Sarcopenia in Older People (EWGSOP 1 and 2), and to propose a new sarcopenia phenotype score (SPS) to improve relevance of clinical outcomes. Methods Analyses were performed in 1408 older adults of the Aging Study of PyeongChang Rural Area, a community‐based cohort in Korea. For sarcopenia definitions, we used EWGSOP 1, EWGSOP 2, and SPS, a new index counting number of abnormal domains among components of grip strength, gait speed, or muscle mass. Frailty status by the frailty index and the Cardiovascular Health Study frailty score was compared with sarcopenia measures. Prediction ability for composite outcome combining death and institutionalization due to functional decline was assessed among sarcopenia measures. Results Generally, sarcopenia spectrum by both EWGSOP 1 and 2 was associated with worse functional status in parameters of geriatric assessments. However, population who were considered as sarcopenic by EWGSOP 1, but not by EWGSOP 2, showed increased risk of composite outcome and worse frailty status, compared with people who were classified as not sarcopenic by both EWGSOP 1 and 2. With SPS, dose–response relationship was observed with both frailty status and outcome prediction. Prediction for composite outcome was better in SPS than in EWGSOP 2 classification. Conclusions A new SPS might be used to classify sarcopenic burden in older adults to resolve possible inconsistencies in phenotype correlation and outcome prediction of EWGSOP 2 criteria. |
| first_indexed | 2024-04-24T08:17:56Z |
| format | Article |
| id | doaj.art-28e9d1096f5f4175a1db48371524d7ec |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:17:56Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-28e9d1096f5f4175a1db48371524d7ec2024-04-17T02:41:52ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092020-04-0111249750410.1002/jcsm.12507Characteristics of sarcopenia by European consensuses and a phenotype scoreIl‐Young Jang0Eunju Lee1Heayon Lee2Hyungchul Park3Sunyoung Kim4Kwang‐il Kim5Hee‐Won Jung6Dae Hyun Kim7Department of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of KoreaDepartment of Internal Medicine, Asan Medical Center University of Ulsan College of Medicine Seoul Republic of KoreaDepartment of Family Medicine Kyung Hee University Medical Center Seoul Republic of KoreaDivision of Geriatrics, Department of Internal Medicine Seoul National University Bundang Hospital Republic of KoreaDepartment of Internal Medicine Seoul National University Hospital Seoul Republic of KoreaMarcus Institute for Aging Research Hebrew Senior Life Boston MA USAAbstract Background We aimed to assess the clinical characteristics of sarcopenia by the original and revised European Working Group on Sarcopenia in Older People (EWGSOP 1 and 2), and to propose a new sarcopenia phenotype score (SPS) to improve relevance of clinical outcomes. Methods Analyses were performed in 1408 older adults of the Aging Study of PyeongChang Rural Area, a community‐based cohort in Korea. For sarcopenia definitions, we used EWGSOP 1, EWGSOP 2, and SPS, a new index counting number of abnormal domains among components of grip strength, gait speed, or muscle mass. Frailty status by the frailty index and the Cardiovascular Health Study frailty score was compared with sarcopenia measures. Prediction ability for composite outcome combining death and institutionalization due to functional decline was assessed among sarcopenia measures. Results Generally, sarcopenia spectrum by both EWGSOP 1 and 2 was associated with worse functional status in parameters of geriatric assessments. However, population who were considered as sarcopenic by EWGSOP 1, but not by EWGSOP 2, showed increased risk of composite outcome and worse frailty status, compared with people who were classified as not sarcopenic by both EWGSOP 1 and 2. With SPS, dose–response relationship was observed with both frailty status and outcome prediction. Prediction for composite outcome was better in SPS than in EWGSOP 2 classification. Conclusions A new SPS might be used to classify sarcopenic burden in older adults to resolve possible inconsistencies in phenotype correlation and outcome prediction of EWGSOP 2 criteria.https://doi.org/10.1002/jcsm.12507SarcopeniaFrailtyValidationOutcomeProspective study |
| spellingShingle | Il‐Young Jang Eunju Lee Heayon Lee Hyungchul Park Sunyoung Kim Kwang‐il Kim Hee‐Won Jung Dae Hyun Kim Characteristics of sarcopenia by European consensuses and a phenotype score Journal of Cachexia, Sarcopenia and Muscle Sarcopenia Frailty Validation Outcome Prospective study |
| title | Characteristics of sarcopenia by European consensuses and a phenotype score |
| title_full | Characteristics of sarcopenia by European consensuses and a phenotype score |
| title_fullStr | Characteristics of sarcopenia by European consensuses and a phenotype score |
| title_full_unstemmed | Characteristics of sarcopenia by European consensuses and a phenotype score |
| title_short | Characteristics of sarcopenia by European consensuses and a phenotype score |
| title_sort | characteristics of sarcopenia by european consensuses and a phenotype score |
| topic | Sarcopenia Frailty Validation Outcome Prospective study |
| url | https://doi.org/10.1002/jcsm.12507 |
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