The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines
The COVID-19 pandemic has led the world to undertake the largest vaccination campaign in human history. In record time, unprecedented scientific and governmental efforts have resulted in the acquisition of immunizers utilizing different technologies (nucleotide acids, viral vectors, inactivated and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/4/591 |
| _version_ | 1797443278047543296 |
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| author | Bruna Aparecida Souza Machado Katharine Valéria Saraiva Hodel Larissa Moraes dos Santos Fonseca Vinícius Couto Pires Luis Alberto Brêda Mascarenhas Leone Peter Correia da Silva Andrade Marcelo Albano Moret Roberto Badaró |
| author_facet | Bruna Aparecida Souza Machado Katharine Valéria Saraiva Hodel Larissa Moraes dos Santos Fonseca Vinícius Couto Pires Luis Alberto Brêda Mascarenhas Leone Peter Correia da Silva Andrade Marcelo Albano Moret Roberto Badaró |
| author_sort | Bruna Aparecida Souza Machado |
| collection | DOAJ |
| description | The COVID-19 pandemic has led the world to undertake the largest vaccination campaign in human history. In record time, unprecedented scientific and governmental efforts have resulted in the acquisition of immunizers utilizing different technologies (nucleotide acids, viral vectors, inactivated and protein-based vaccines). Currently, 33 vaccines have already been approved by regulatory agencies in different countries, and more than 10 billion doses have been administered worldwide. Despite the undeniable impact of vaccination on the control of the pandemic, the recurrent emergence of new variants of interest has raised new challenges. The recent viral mutations precede new outbreaks that rapidly spread at global proportions. In addition, reducing protective efficacy rates have been observed among the main authorized vaccines. Besides these issues, several other crucial issues for the appropriate combatting of the pandemic remain uncertain or under investigation. Particularly noteworthy issues include the use of vaccine-boosting strategies to increase protection; concerns related to the long-term safety of vaccines, child immunization reliability and uncommon adverse events; the persistence of the virus in society; and the transition from a pandemic to an endemic state. In this review, we describe the updated scenario regarding SARS-CoV-2 variants and COVID-19 vaccines. In addition, we outline current discussions covering COVID-19 vaccine safety and efficacy, and the future pandemic perspectives. |
| first_indexed | 2024-03-09T12:53:38Z |
| format | Article |
| id | doaj.art-28e9e4319f0848ceb3bebd9666d5f09c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:53:38Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-28e9e4319f0848ceb3bebd9666d5f09c2023-11-30T22:02:24ZengMDPI AGVaccines2076-393X2022-04-0110459110.3390/vaccines10040591The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of VaccinesBruna Aparecida Souza Machado0Katharine Valéria Saraiva Hodel1Larissa Moraes dos Santos Fonseca2Vinícius Couto Pires3Luis Alberto Brêda Mascarenhas4Leone Peter Correia da Silva Andrade5Marcelo Albano Moret6Roberto Badaró7SENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), University Center SENAI/CIMATEC, Salvador 41650-010, BrazilThe COVID-19 pandemic has led the world to undertake the largest vaccination campaign in human history. In record time, unprecedented scientific and governmental efforts have resulted in the acquisition of immunizers utilizing different technologies (nucleotide acids, viral vectors, inactivated and protein-based vaccines). Currently, 33 vaccines have already been approved by regulatory agencies in different countries, and more than 10 billion doses have been administered worldwide. Despite the undeniable impact of vaccination on the control of the pandemic, the recurrent emergence of new variants of interest has raised new challenges. The recent viral mutations precede new outbreaks that rapidly spread at global proportions. In addition, reducing protective efficacy rates have been observed among the main authorized vaccines. Besides these issues, several other crucial issues for the appropriate combatting of the pandemic remain uncertain or under investigation. Particularly noteworthy issues include the use of vaccine-boosting strategies to increase protection; concerns related to the long-term safety of vaccines, child immunization reliability and uncommon adverse events; the persistence of the virus in society; and the transition from a pandemic to an endemic state. In this review, we describe the updated scenario regarding SARS-CoV-2 variants and COVID-19 vaccines. In addition, we outline current discussions covering COVID-19 vaccine safety and efficacy, and the future pandemic perspectives.https://www.mdpi.com/2076-393X/10/4/591COVID-19vaccinesSARS-CoV-2COVpandemic |
| spellingShingle | Bruna Aparecida Souza Machado Katharine Valéria Saraiva Hodel Larissa Moraes dos Santos Fonseca Vinícius Couto Pires Luis Alberto Brêda Mascarenhas Leone Peter Correia da Silva Andrade Marcelo Albano Moret Roberto Badaró The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines Vaccines COVID-19 vaccines SARS-CoV-2 COV pandemic |
| title | The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines |
| title_full | The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines |
| title_fullStr | The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines |
| title_full_unstemmed | The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines |
| title_short | The Importance of Vaccination in the Context of the COVID-19 Pandemic: A Brief Update Regarding the Use of Vaccines |
| title_sort | importance of vaccination in the context of the covid 19 pandemic a brief update regarding the use of vaccines |
| topic | COVID-19 vaccines SARS-CoV-2 COV pandemic |
| url | https://www.mdpi.com/2076-393X/10/4/591 |
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