Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters
Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during chi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3629 |
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| author | Marie Gombert Vanessa Martin-Carbonell Gonzalo Pin-Arboledas Joaquín Carrasco-Luna Álvaro Carrasco-García Pilar Codoñer-Franch |
| author_facet | Marie Gombert Vanessa Martin-Carbonell Gonzalo Pin-Arboledas Joaquín Carrasco-Luna Álvaro Carrasco-García Pilar Codoñer-Franch |
| author_sort | Marie Gombert |
| collection | DOAJ |
| description | Melatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during childhood are scarce. The present study investigated the association of melatonin with metabolic and inflammatory markers in children with (<i>n</i> = 113) and without obesity (<i>n</i> = 117). Melatonin was measured in saliva four and two hours before bedtime, and after one hour of sleep. Cardiometabolic factors, high sensitivity C-reactive protein, immune markers (monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, tumor necrosis α and interferon-γ), leptin and ghrelin were determined. Sleep duration was recorded by a questionnaire. The melatonin level at 1 h after sleep was found to be increased more than twofold in children with obesity (90.16 (57.16–129.16) pg/mL) compared to controls (29.82 (19.05–61.54) pg/mL, <i>p</i> < 0.001) and was related to fat mass (rho = 0.294, <i>p</i> < 0.001); melatonin levels at 1 h after sleep were inversely correlated with high-density lipoprotein cholesterol. Positive correlation was found with apolipoprotein B, adipokines, high sensitivity C-reactive protein, plasminogen activator inhibitor-1 and tumor necrosis factor-α. Shorter sleep duration and earlier waking times were recorded in children with obesity. In conclusion, melatonin in children with obesity appears to be involved in the global metabolic and inflammatory alteration of this condition. |
| first_indexed | 2024-03-10T06:17:58Z |
| format | Article |
| id | doaj.art-28eccafa5ea14d72b50a86e82b94eb65 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:17:58Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-28eccafa5ea14d72b50a86e82b94eb652023-11-22T19:31:43ZengMDPI AGNutrients2072-66432021-10-011310362910.3390/nu13103629Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory ParametersMarie Gombert0Vanessa Martin-Carbonell1Gonzalo Pin-Arboledas2Joaquín Carrasco-Luna3Álvaro Carrasco-García4Pilar Codoñer-Franch5Department of Pediatrics, Obstetrics and Gynecology, Universidad de Valencia, 46010 Valencia, SpainDepartment of Pediatrics, Obstetrics and Gynecology, Universidad de Valencia, 46010 Valencia, SpainPediatric Sleep Unit, Department of Pediatrics, Quironsalud Hospital, 46010 Valencia, SpainDepartment of Experimental Sciences, Universitat Católica de Valencia, 46001 Valencia, SpainDepartment of Pediatrics, Obstetrics and Gynecology, Universidad de Valencia, 46010 Valencia, SpainDepartment of Pediatrics, Obstetrics and Gynecology, Universidad de Valencia, 46010 Valencia, SpainMelatonin, the hormone of circadian rhythm regulation, is involved in the modulation of mitochondrial activity through its antioxidant and anti-inflammatory properties. Alteration of circadian rhythms such as sleep is related to obesity and metabolic pathogenesis in adulthood, but studies during childhood are scarce. The present study investigated the association of melatonin with metabolic and inflammatory markers in children with (<i>n</i> = 113) and without obesity (<i>n</i> = 117). Melatonin was measured in saliva four and two hours before bedtime, and after one hour of sleep. Cardiometabolic factors, high sensitivity C-reactive protein, immune markers (monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, tumor necrosis α and interferon-γ), leptin and ghrelin were determined. Sleep duration was recorded by a questionnaire. The melatonin level at 1 h after sleep was found to be increased more than twofold in children with obesity (90.16 (57.16–129.16) pg/mL) compared to controls (29.82 (19.05–61.54) pg/mL, <i>p</i> < 0.001) and was related to fat mass (rho = 0.294, <i>p</i> < 0.001); melatonin levels at 1 h after sleep were inversely correlated with high-density lipoprotein cholesterol. Positive correlation was found with apolipoprotein B, adipokines, high sensitivity C-reactive protein, plasminogen activator inhibitor-1 and tumor necrosis factor-α. Shorter sleep duration and earlier waking times were recorded in children with obesity. In conclusion, melatonin in children with obesity appears to be involved in the global metabolic and inflammatory alteration of this condition.https://www.mdpi.com/2072-6643/13/10/3629melatoninchildhood obesitymetabolismlow-grade inflammationcircadian rhythms |
| spellingShingle | Marie Gombert Vanessa Martin-Carbonell Gonzalo Pin-Arboledas Joaquín Carrasco-Luna Álvaro Carrasco-García Pilar Codoñer-Franch Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters Nutrients melatonin childhood obesity metabolism low-grade inflammation circadian rhythms |
| title | Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters |
| title_full | Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters |
| title_fullStr | Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters |
| title_full_unstemmed | Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters |
| title_short | Melatonin Levels in Children with Obesity Are Associated with Metabolic Risk and Inflammatory Parameters |
| title_sort | melatonin levels in children with obesity are associated with metabolic risk and inflammatory parameters |
| topic | melatonin childhood obesity metabolism low-grade inflammation circadian rhythms |
| url | https://www.mdpi.com/2072-6643/13/10/3629 |
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