Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses
While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-07-01
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| Series: | Vaccines |
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| Online Access: | http://www.mdpi.com/2076-393X/2/3/537 |
| _version_ | 1811187633685004288 |
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| author | Graham R. Leggatt |
| author_facet | Graham R. Leggatt |
| author_sort | Graham R. Leggatt |
| collection | DOAJ |
| description | While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to any given peptide is variable, but broader than a single clone. Consequently, peptide parameters that affect the interaction between T cells and peptide/MHC have been shown to select particular T cell clones for expansion and this impacts on clearance of disease. T cells with high functional avidity are selected on low doses of peptide, while low avidity T cells are favoured in high peptide concentrations. Altering the structure of the peptide ligand can also influence the selection and function of peptide-specific T cell clones. In this review, we will explore the evidence that the choice of peptide dose or the structure of the peptide are critical parameters in an effective vaccine designed to activate T cells. |
| first_indexed | 2024-04-11T14:05:36Z |
| format | Article |
| id | doaj.art-28eccbbd2e4e43529356f48c05e24910 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-11T14:05:36Z |
| publishDate | 2014-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-28eccbbd2e4e43529356f48c05e249102022-12-22T04:19:53ZengMDPI AGVaccines2076-393X2014-07-012353754810.3390/vaccines2030537vaccines2030537Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell ResponsesGraham R. Leggatt0The University of Queensland Diamantina Institute, Translational Research Institute, 37 Kent Street, Woolloongabba, Brisbane QLD 4102, AustraliaWhile T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to any given peptide is variable, but broader than a single clone. Consequently, peptide parameters that affect the interaction between T cells and peptide/MHC have been shown to select particular T cell clones for expansion and this impacts on clearance of disease. T cells with high functional avidity are selected on low doses of peptide, while low avidity T cells are favoured in high peptide concentrations. Altering the structure of the peptide ligand can also influence the selection and function of peptide-specific T cell clones. In this review, we will explore the evidence that the choice of peptide dose or the structure of the peptide are critical parameters in an effective vaccine designed to activate T cells.http://www.mdpi.com/2076-393X/2/3/537vaccinationT cell avidityaltered peptide ligandspeptide dosepeptide structurepeptide vaccinesfunctional avidity |
| spellingShingle | Graham R. Leggatt Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses Vaccines vaccination T cell avidity altered peptide ligands peptide dose peptide structure peptide vaccines functional avidity |
| title | Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_full | Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_fullStr | Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_full_unstemmed | Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_short | Peptide Dose and/or Structure in Vaccines as a Determinant of T Cell Responses |
| title_sort | peptide dose and or structure in vaccines as a determinant of t cell responses |
| topic | vaccination T cell avidity altered peptide ligands peptide dose peptide structure peptide vaccines functional avidity |
| url | http://www.mdpi.com/2076-393X/2/3/537 |
| work_keys_str_mv | AT grahamrleggatt peptidedoseandorstructureinvaccinesasadeterminantoftcellresponses |