Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT
<b>Background:</b> Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation classified according to the WHO as nondestructive, polymorphic, monomorphic, and classic Hodgkin Lymphoma subtypes. In this retrospective study, we investigated the potential...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| author | Filipe Montes de Jesus Vibeke Vergote Walter Noordzij Daan Dierickx Rudi Dierckx Arjan Diepstra Thomas Tousseyn Olivier Gheysens Thomas Kwee Christophe Deroose Andor Glaudemans |
| author_facet | Filipe Montes de Jesus Vibeke Vergote Walter Noordzij Daan Dierickx Rudi Dierckx Arjan Diepstra Thomas Tousseyn Olivier Gheysens Thomas Kwee Christophe Deroose Andor Glaudemans |
| author_sort | Filipe Montes de Jesus |
| collection | DOAJ |
| description | <b>Background:</b> Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation classified according to the WHO as nondestructive, polymorphic, monomorphic, and classic Hodgkin Lymphoma subtypes. In this retrospective study, we investigated the potential of semi-quantitative 2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose ([<sup>18</sup>F]FDG) PET/computed tomography (CT)-based parameters to differentiate between the PTLD morphological subtypes. <b>Methods:</b> 96 patients with histopathologically confirmed PTLD and baseline [<sup>18</sup>F]FDG PET/CT between 2009 and 2019 were included. Extracted semi-quantitative measurements included: Maximum, peak, and mean standardized uptake value (SUV<sub>max</sub>, SUV<sub>peak</sub>, and SUV<sub>mean</sub>). <b>Results:</b> Median SUVs were highest for monomorphic PTLD followed by polymorphic and nondestructive subtypes. The median SUV<sub>peak</sub> at the biopsy site was significantly higher in monomorphic PTLD (17.8, interquartile range (IQR):16) than in polymorphic subtypes (9.8, IQR:13.4) and nondestructive (4.1, IQR:6.1) (<i>p</i> = 0.04 and <i>p</i> ≤ 0.01, respectively). An SUV<sub>peak</sub> ≥ 24.8 was always indicative of a monomorphic PTLD in our dataset. Nevertheless, there was a considerable overlap in SUV across the different morphologies. <b>Conclusion:</b> The median SUV<sub>peak</sub> at the biopsy site was significantly higher in monomorphic PTLD than polymorphic and nondestructive subtypes. However, due to significant SUV overlap across the different subtypes, these values may only serve as an indication of PTLD morphology, and SUV-based parameters cannot replace histopathological classification. |
| first_indexed | 2024-03-09T04:18:44Z |
| format | Article |
| id | doaj.art-28ecfc16f4b843cea0a49c8f8256b8b4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:18:44Z |
| publishDate | 2021-01-01 |
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| spelling | doaj.art-28ecfc16f4b843cea0a49c8f8256b8b42023-12-03T13:49:20ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110236110.3390/jcm10020361Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CTFilipe Montes de Jesus0Vibeke Vergote1Walter Noordzij2Daan Dierickx3Rudi Dierckx4Arjan Diepstra5Thomas Tousseyn6Olivier Gheysens7Thomas Kwee8Christophe Deroose9Andor Glaudemans10Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Hematology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Hematology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pathology University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Nuclear Medicine, Cliniques Universitaires Saint-Luc, 1200 Brussels, BelgiumDepartment of Radiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The NetherlandsDepartment of Nuclear Medicine, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands<b>Background:</b> Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation classified according to the WHO as nondestructive, polymorphic, monomorphic, and classic Hodgkin Lymphoma subtypes. In this retrospective study, we investigated the potential of semi-quantitative 2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose ([<sup>18</sup>F]FDG) PET/computed tomography (CT)-based parameters to differentiate between the PTLD morphological subtypes. <b>Methods:</b> 96 patients with histopathologically confirmed PTLD and baseline [<sup>18</sup>F]FDG PET/CT between 2009 and 2019 were included. Extracted semi-quantitative measurements included: Maximum, peak, and mean standardized uptake value (SUV<sub>max</sub>, SUV<sub>peak</sub>, and SUV<sub>mean</sub>). <b>Results:</b> Median SUVs were highest for monomorphic PTLD followed by polymorphic and nondestructive subtypes. The median SUV<sub>peak</sub> at the biopsy site was significantly higher in monomorphic PTLD (17.8, interquartile range (IQR):16) than in polymorphic subtypes (9.8, IQR:13.4) and nondestructive (4.1, IQR:6.1) (<i>p</i> = 0.04 and <i>p</i> ≤ 0.01, respectively). An SUV<sub>peak</sub> ≥ 24.8 was always indicative of a monomorphic PTLD in our dataset. Nevertheless, there was a considerable overlap in SUV across the different morphologies. <b>Conclusion:</b> The median SUV<sub>peak</sub> at the biopsy site was significantly higher in monomorphic PTLD than polymorphic and nondestructive subtypes. However, due to significant SUV overlap across the different subtypes, these values may only serve as an indication of PTLD morphology, and SUV-based parameters cannot replace histopathological classification.https://www.mdpi.com/2077-0383/10/2/361post-transplant lymphoproliferative disorder2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose positron emission tomographyFDG-PET/CTsemi-quantificationstandardized uptake value |
| spellingShingle | Filipe Montes de Jesus Vibeke Vergote Walter Noordzij Daan Dierickx Rudi Dierckx Arjan Diepstra Thomas Tousseyn Olivier Gheysens Thomas Kwee Christophe Deroose Andor Glaudemans Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT Journal of Clinical Medicine post-transplant lymphoproliferative disorder 2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose positron emission tomography FDG-PET/CT semi-quantification standardized uptake value |
| title | Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT |
| title_full | Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT |
| title_fullStr | Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT |
| title_full_unstemmed | Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT |
| title_short | Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [<sup>18</sup>F]FDG PET/CT |
| title_sort | semi quantitative characterization of post transplant lymphoproliferative disorder morphological subtypes with sup 18 sup f fdg pet ct |
| topic | post-transplant lymphoproliferative disorder 2-[<sup>18</sup>F]fluoro-2-deoxy-D-glucose positron emission tomography FDG-PET/CT semi-quantification standardized uptake value |
| url | https://www.mdpi.com/2077-0383/10/2/361 |
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