The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial
Abstract Background Exercise reduces the amount of visceral adipose tissue (VAT) and the risk of cardiometabolic diseases. The underlying mechanisms responsible for these exercise-induced adaptations are unclear, but they may involve lipolytic actions of interleukin-6 (IL-6). Contracting skeletal mu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-018-2637-0 |
| _version_ | 1811237921541324800 |
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| author | Regitse Højgaard Christensen Anne-Sophie Wedell-Neergaard Louise Lang Lehrskov Grit Elster Legård Emma Berndt Dorph Stine Nymand Maria Korf Ball Morten Zacho Robin Christensen Helga Ellingsgaard Jaya Birgitte Rosenmeier Rikke Krogh-Madsen Bente Klarlund Pedersen Kristian Karstoft |
| author_facet | Regitse Højgaard Christensen Anne-Sophie Wedell-Neergaard Louise Lang Lehrskov Grit Elster Legård Emma Berndt Dorph Stine Nymand Maria Korf Ball Morten Zacho Robin Christensen Helga Ellingsgaard Jaya Birgitte Rosenmeier Rikke Krogh-Madsen Bente Klarlund Pedersen Kristian Karstoft |
| author_sort | Regitse Højgaard Christensen |
| collection | DOAJ |
| description | Abstract Background Exercise reduces the amount of visceral adipose tissue (VAT) and the risk of cardiometabolic diseases. The underlying mechanisms responsible for these exercise-induced adaptations are unclear, but they may involve lipolytic actions of interleukin-6 (IL-6). Contracting skeletal muscles secrete IL-6, leading to increased circulating IL-6 levels in response to exercise. The aim of this study is to investigate whether IL-6 is involved in mediating the effects of exercise on visceral and epicardial adipose tissue volume and glycaemic control. Methods/design Seventy-five physically inactive males and females aged > 18 years with a waist-to-height ratio > 0.5 and/or waist circumference ≥ 88 cm (females) or ≥ 102 cm (males) are being recruited to participate in a 12-week intervention study. Participants are randomly allocated to one of five groups (1:1:1:1:1). Two groups consist of supervised endurance exercise training combined with the IL-6 blocker tocilizumab (ET) or saline used as placebo (EP), two groups consist of no exercise combined with tocilizumab (NT) or placebo (NP), and one group consists of resistance exercise and placebo (RP). Although the study is an exploratory trial, the primary outcome is change in VAT volume from before to after intervention, with secondary outcomes being changes in (1) epicardial adipose tissue, (2) pericardial adipose tissue and (3) gastric emptying. Depots of adipose tissue are quantitated by magnetic resonance imaging Gastric emptying and glucose metabolism are assessed using mixed-meal tolerance tests. Discussion Understanding the role of IL-6 in mediating the effects of exercise on visceral and epicardial adipose tissue and glycaemic control may lead to novel therapeutic approaches in the prevention of cardiometabolic diseases. Trial registration ClinicalTrials.gov, NCT02901496. Registered on 1 August 2016 and posted retrospectively on 15 September 2016. |
| first_indexed | 2024-04-12T12:31:43Z |
| format | Article |
| id | doaj.art-28ed7dbc709f4e7bb081a31021a9fdf7 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-12T12:31:43Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-28ed7dbc709f4e7bb081a31021a9fdf72022-12-22T03:33:00ZengBMCTrials1745-62152018-05-0119111110.1186/s13063-018-2637-0The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trialRegitse Højgaard Christensen0Anne-Sophie Wedell-Neergaard1Louise Lang Lehrskov2Grit Elster Legård3Emma Berndt Dorph4Stine Nymand5Maria Korf Ball6Morten Zacho7Robin Christensen8Helga Ellingsgaard9Jaya Birgitte Rosenmeier10Rikke Krogh-Madsen11Bente Klarlund Pedersen12Kristian Karstoft13The Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenMusculoskeletal Statistics Unit, The Parker Institute, Bispebjerg and Frederiksberg HospitalThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenDepartment of Cardiology, Copenhagen University Hospital Bispebjerg, Capital Region of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenThe Centre of Inflammation and Metabolism (CIM) and The Centre for Physical Activity Research (CFAS), Rigshospitalet, University of CopenhagenAbstract Background Exercise reduces the amount of visceral adipose tissue (VAT) and the risk of cardiometabolic diseases. The underlying mechanisms responsible for these exercise-induced adaptations are unclear, but they may involve lipolytic actions of interleukin-6 (IL-6). Contracting skeletal muscles secrete IL-6, leading to increased circulating IL-6 levels in response to exercise. The aim of this study is to investigate whether IL-6 is involved in mediating the effects of exercise on visceral and epicardial adipose tissue volume and glycaemic control. Methods/design Seventy-five physically inactive males and females aged > 18 years with a waist-to-height ratio > 0.5 and/or waist circumference ≥ 88 cm (females) or ≥ 102 cm (males) are being recruited to participate in a 12-week intervention study. Participants are randomly allocated to one of five groups (1:1:1:1:1). Two groups consist of supervised endurance exercise training combined with the IL-6 blocker tocilizumab (ET) or saline used as placebo (EP), two groups consist of no exercise combined with tocilizumab (NT) or placebo (NP), and one group consists of resistance exercise and placebo (RP). Although the study is an exploratory trial, the primary outcome is change in VAT volume from before to after intervention, with secondary outcomes being changes in (1) epicardial adipose tissue, (2) pericardial adipose tissue and (3) gastric emptying. Depots of adipose tissue are quantitated by magnetic resonance imaging Gastric emptying and glucose metabolism are assessed using mixed-meal tolerance tests. Discussion Understanding the role of IL-6 in mediating the effects of exercise on visceral and epicardial adipose tissue and glycaemic control may lead to novel therapeutic approaches in the prevention of cardiometabolic diseases. Trial registration ClinicalTrials.gov, NCT02901496. Registered on 1 August 2016 and posted retrospectively on 15 September 2016.http://link.springer.com/article/10.1186/s13063-018-2637-0Visceral adipose tissueEpicardial adipose tissueGlucose homeostasisGastric emptying rateInterleukin-6Exercise |
| spellingShingle | Regitse Højgaard Christensen Anne-Sophie Wedell-Neergaard Louise Lang Lehrskov Grit Elster Legård Emma Berndt Dorph Stine Nymand Maria Korf Ball Morten Zacho Robin Christensen Helga Ellingsgaard Jaya Birgitte Rosenmeier Rikke Krogh-Madsen Bente Klarlund Pedersen Kristian Karstoft The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial Trials Visceral adipose tissue Epicardial adipose tissue Glucose homeostasis Gastric emptying rate Interleukin-6 Exercise |
| title | The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial |
| title_full | The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial |
| title_fullStr | The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial |
| title_full_unstemmed | The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial |
| title_short | The role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants: protocol for a randomised controlled trial |
| title_sort | role of exercise combined with tocilizumab in visceral and epicardial adipose tissue and gastric emptying rate in abdominally obese participants protocol for a randomised controlled trial |
| topic | Visceral adipose tissue Epicardial adipose tissue Glucose homeostasis Gastric emptying rate Interleukin-6 Exercise |
| url | http://link.springer.com/article/10.1186/s13063-018-2637-0 |
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