Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
Summary: Cellular signaling involves a large repertoire of membrane receptors operating in overlapping spatiotemporal regimes and targeting many common intracellular effectors. However, both the molecular mechanisms and the physiological roles of crosstalk between receptors, especially those from di...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723016078 |
| _version_ | 1797384051271663616 |
|---|---|
| author | Cristina Lao-Peregrin Guoqing Xiang Jihye Kim Ipsit Srivastava Alexandra B. Fall Danielle M. Gerhard Piia Kohtala Daegeon Kim Minseok Song Mikel Garcia-Marcos Joshua Levitz Francis S. Lee |
| author_facet | Cristina Lao-Peregrin Guoqing Xiang Jihye Kim Ipsit Srivastava Alexandra B. Fall Danielle M. Gerhard Piia Kohtala Daegeon Kim Minseok Song Mikel Garcia-Marcos Joshua Levitz Francis S. Lee |
| author_sort | Cristina Lao-Peregrin |
| collection | DOAJ |
| description | Summary: Cellular signaling involves a large repertoire of membrane receptors operating in overlapping spatiotemporal regimes and targeting many common intracellular effectors. However, both the molecular mechanisms and the physiological roles of crosstalk between receptors, especially those from different superfamilies, are poorly understood. We find that the receptor tyrosine kinase (RTK) TrkB and the G-protein-coupled receptor (GPCR) metabotropic glutamate receptor 5 (mGluR5) together mediate hippocampal synaptic plasticity in response to brain-derived neurotrophic factor (BDNF). Activated TrkB enhances constitutive mGluR5 activity to initiate a mode switch that drives BDNF-dependent sustained, oscillatory Ca2+ signaling and enhanced MAP kinase activation. This crosstalk is mediated, in part, by synergy between Gβγ, released by TrkB, and Gαq-GTP, released by mGluR5, to enable physiologically relevant RTK/GPCR crosstalk. |
| first_indexed | 2024-03-08T21:29:53Z |
| format | Article |
| id | doaj.art-28edfc249a87468a91385cfb259ade66 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T21:29:53Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-28edfc249a87468a91385cfb259ade662023-12-21T07:32:36ZengElsevierCell Reports2211-12472024-01-01431113595Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalkCristina Lao-Peregrin0Guoqing Xiang1Jihye Kim2Ipsit Srivastava3Alexandra B. Fall4Danielle M. Gerhard5Piia Kohtala6Daegeon Kim7Minseok Song8Mikel Garcia-Marcos9Joshua Levitz10Francis S. Lee11Department of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USADepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USADepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USADepartment of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USADepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USADepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USADepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USADepartment of Life Sciences, Yeongnam University, Gyeongsan, Gyeongbuk 38451, South KoreaDepartment of Life Sciences, Yeongnam University, Gyeongsan, Gyeongbuk 38451, South KoreaDepartment of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USADepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Department of Biochemistry, Weill Cornell Medicine, New York, NY 10065, USA; Corresponding authorDepartment of Psychiatry, Weill Cornell Medicine. New York, NY 10065, USA; Corresponding authorSummary: Cellular signaling involves a large repertoire of membrane receptors operating in overlapping spatiotemporal regimes and targeting many common intracellular effectors. However, both the molecular mechanisms and the physiological roles of crosstalk between receptors, especially those from different superfamilies, are poorly understood. We find that the receptor tyrosine kinase (RTK) TrkB and the G-protein-coupled receptor (GPCR) metabotropic glutamate receptor 5 (mGluR5) together mediate hippocampal synaptic plasticity in response to brain-derived neurotrophic factor (BDNF). Activated TrkB enhances constitutive mGluR5 activity to initiate a mode switch that drives BDNF-dependent sustained, oscillatory Ca2+ signaling and enhanced MAP kinase activation. This crosstalk is mediated, in part, by synergy between Gβγ, released by TrkB, and Gαq-GTP, released by mGluR5, to enable physiologically relevant RTK/GPCR crosstalk.http://www.sciencedirect.com/science/article/pii/S2211124723016078CP: Cell biologyCP: Neuroscience |
| spellingShingle | Cristina Lao-Peregrin Guoqing Xiang Jihye Kim Ipsit Srivastava Alexandra B. Fall Danielle M. Gerhard Piia Kohtala Daegeon Kim Minseok Song Mikel Garcia-Marcos Joshua Levitz Francis S. Lee Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk Cell Reports CP: Cell biology CP: Neuroscience |
| title | Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk |
| title_full | Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk |
| title_fullStr | Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk |
| title_full_unstemmed | Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk |
| title_short | Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk |
| title_sort | synaptic plasticity via receptor tyrosine kinase g protein coupled receptor crosstalk |
| topic | CP: Cell biology CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723016078 |
| work_keys_str_mv | AT cristinalaoperegrin synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT guoqingxiang synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT jihyekim synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT ipsitsrivastava synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT alexandrabfall synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT daniellemgerhard synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT piiakohtala synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT daegeonkim synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT minseoksong synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT mikelgarciamarcos synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT joshualevitz synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk AT francisslee synapticplasticityviareceptortyrosinekinasegproteincoupledreceptorcrosstalk |