The Role of Selected Natural Biomolecules in Sperm Production and Functionality
Emerging evidence from in vivo as well as in vitro studies indicates that natural biomolecules may play important roles in the prevention or management of a wide array of chronic diseases. Furthermore, the use of natural compounds in the treatment of male sub- or infertility has been proposed as a p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/17/5196 |
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| author | Eva Tvrdá Filip Benko Tomáš Slanina Stefan S. du Plessis |
| author_facet | Eva Tvrdá Filip Benko Tomáš Slanina Stefan S. du Plessis |
| author_sort | Eva Tvrdá |
| collection | DOAJ |
| description | Emerging evidence from in vivo as well as in vitro studies indicates that natural biomolecules may play important roles in the prevention or management of a wide array of chronic diseases. Furthermore, the use of natural compounds in the treatment of male sub- or infertility has been proposed as a potential alternative to conventional therapeutic options. As such, we aimed to evaluate the effects of selected natural biomolecules on the sperm production, structural integrity, and functional activity. At the same time, we reviewed their possible beneficial or adverse effects on male reproductive health. Using relevant keywords, a literature search was performed to collect currently available information regarding molecular mechanisms by which selected natural biomolecules exhibit their biological effects in the context of male reproductive dysfunction. Evidence gathered from clinical trials, in vitro experiments and in vivo studies suggest that the selected natural compounds affect key targets related to sperm mitochondrial metabolism and motion behavior, oxidative stress, inflammation, DNA integrity and cell death. The majority of reports emphasize on ameliorative, stimulating and protective effects of natural biomolecules on the sperm function. Nevertheless, possible adverse and toxic behavior of natural compounds has been indicated as well, pointing out to a possible dose-dependent impact of natural biomolecules on the sperm survival and functionality. As such, further research leading to a deeper understanding of the beneficial or adverse roles of natural compounds is necessary before these can be employed for the management of male reproductive dysfunction. |
| first_indexed | 2024-03-10T08:06:37Z |
| format | Article |
| id | doaj.art-28ee2c93f9e44413b2978f39468d5219 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:06:37Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-28ee2c93f9e44413b2978f39468d52192023-11-22T11:00:31ZengMDPI AGMolecules1420-30492021-08-012617519610.3390/molecules26175196The Role of Selected Natural Biomolecules in Sperm Production and FunctionalityEva Tvrdá0Filip Benko1Tomáš Slanina2Stefan S. du Plessis3Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, SlovakiaDepartment of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, SlovakiaDepartment of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture, Tr. A. Hlinku 2, 94976 Nitra, SlovakiaDepartment of Basic Sciences, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai 505055, United Arab EmiratesEmerging evidence from in vivo as well as in vitro studies indicates that natural biomolecules may play important roles in the prevention or management of a wide array of chronic diseases. Furthermore, the use of natural compounds in the treatment of male sub- or infertility has been proposed as a potential alternative to conventional therapeutic options. As such, we aimed to evaluate the effects of selected natural biomolecules on the sperm production, structural integrity, and functional activity. At the same time, we reviewed their possible beneficial or adverse effects on male reproductive health. Using relevant keywords, a literature search was performed to collect currently available information regarding molecular mechanisms by which selected natural biomolecules exhibit their biological effects in the context of male reproductive dysfunction. Evidence gathered from clinical trials, in vitro experiments and in vivo studies suggest that the selected natural compounds affect key targets related to sperm mitochondrial metabolism and motion behavior, oxidative stress, inflammation, DNA integrity and cell death. The majority of reports emphasize on ameliorative, stimulating and protective effects of natural biomolecules on the sperm function. Nevertheless, possible adverse and toxic behavior of natural compounds has been indicated as well, pointing out to a possible dose-dependent impact of natural biomolecules on the sperm survival and functionality. As such, further research leading to a deeper understanding of the beneficial or adverse roles of natural compounds is necessary before these can be employed for the management of male reproductive dysfunction.https://www.mdpi.com/1420-3049/26/17/5196natural biomoleculespolyphenolsflavonoidscurcuminlycopenephytoestrogens |
| spellingShingle | Eva Tvrdá Filip Benko Tomáš Slanina Stefan S. du Plessis The Role of Selected Natural Biomolecules in Sperm Production and Functionality Molecules natural biomolecules polyphenols flavonoids curcumin lycopene phytoestrogens |
| title | The Role of Selected Natural Biomolecules in Sperm Production and Functionality |
| title_full | The Role of Selected Natural Biomolecules in Sperm Production and Functionality |
| title_fullStr | The Role of Selected Natural Biomolecules in Sperm Production and Functionality |
| title_full_unstemmed | The Role of Selected Natural Biomolecules in Sperm Production and Functionality |
| title_short | The Role of Selected Natural Biomolecules in Sperm Production and Functionality |
| title_sort | role of selected natural biomolecules in sperm production and functionality |
| topic | natural biomolecules polyphenols flavonoids curcumin lycopene phytoestrogens |
| url | https://www.mdpi.com/1420-3049/26/17/5196 |
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