Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study.
BACKGROUND: The screening of hospital admission patients for methicillin resistant Staphylococcus aureus (MRSA) is of undisputed value in controlling and reducing the overall MRSA burden; yet, a concerted parallel universal screening intervention throughout all hospitals of an entire German Federal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3770647?pdf=render |
| _version_ | 1818457310018666496 |
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| author | Mathias Herrmann Christine Petit Alik Dawson Judith Biechele Alexander Halfmann Lutz von Müller Stefan Gräber Stefan Wagenpfeil Renate Klein Barbara Gärtner |
| author_facet | Mathias Herrmann Christine Petit Alik Dawson Judith Biechele Alexander Halfmann Lutz von Müller Stefan Gräber Stefan Wagenpfeil Renate Klein Barbara Gärtner |
| author_sort | Mathias Herrmann |
| collection | DOAJ |
| description | BACKGROUND: The screening of hospital admission patients for methicillin resistant Staphylococcus aureus (MRSA) is of undisputed value in controlling and reducing the overall MRSA burden; yet, a concerted parallel universal screening intervention throughout all hospitals of an entire German Federal State has not yet been performed. METHODOLOGY/PRINCIPAL FINDINGS: During a four-week period, all 24 acute care hospitals of the State of Saarland participated in admission prevalence screening. Overall, 436/20,027 screened patients revealed MRSA carrier status (prevalence, 2.2/100 patients) with geriatrics and intensive care departments associated with highest prevalence (7.6/100 and 6.3/100, respectively). Risk factor analysis among 17,975 admission patients yielded MRSA history (OR, 4.3; CI₉₅ 2.7-6.8), a skin condition (OR, 3.2; CI₉₅ 2.1-5.0), and/or an indwelling catheter (OR, 2.2; CI₉₅ 1.4-3.5) among the leading risks. Hierarchical risk factor ascertainment of the six risk factors associated with highest odd's ratios would require 31% of patients to be laboratory screened to allow for detection of 67% of all MRSA positive admission patients in the State. CONCLUSIONS/SIGNIFICANCE: State-wide admission prevalence screening in conjunction with risk factor ascertainment yields important information on the distribution of the MRSA burden for hospitals, and allows for data-based decisions on local or institutional MRSA screening policies considering risk factor prevalence and expected MRSA identification rates. |
| first_indexed | 2024-12-14T22:40:32Z |
| format | Article |
| id | doaj.art-28ef1bed602a42fd8eb1be84bd936b31 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T22:40:32Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-28ef1bed602a42fd8eb1be84bd936b312022-12-21T22:45:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7387610.1371/journal.pone.0073876Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study.Mathias HerrmannChristine PetitAlik DawsonJudith BiecheleAlexander HalfmannLutz von MüllerStefan GräberStefan WagenpfeilRenate KleinBarbara GärtnerBACKGROUND: The screening of hospital admission patients for methicillin resistant Staphylococcus aureus (MRSA) is of undisputed value in controlling and reducing the overall MRSA burden; yet, a concerted parallel universal screening intervention throughout all hospitals of an entire German Federal State has not yet been performed. METHODOLOGY/PRINCIPAL FINDINGS: During a four-week period, all 24 acute care hospitals of the State of Saarland participated in admission prevalence screening. Overall, 436/20,027 screened patients revealed MRSA carrier status (prevalence, 2.2/100 patients) with geriatrics and intensive care departments associated with highest prevalence (7.6/100 and 6.3/100, respectively). Risk factor analysis among 17,975 admission patients yielded MRSA history (OR, 4.3; CI₉₅ 2.7-6.8), a skin condition (OR, 3.2; CI₉₅ 2.1-5.0), and/or an indwelling catheter (OR, 2.2; CI₉₅ 1.4-3.5) among the leading risks. Hierarchical risk factor ascertainment of the six risk factors associated with highest odd's ratios would require 31% of patients to be laboratory screened to allow for detection of 67% of all MRSA positive admission patients in the State. CONCLUSIONS/SIGNIFICANCE: State-wide admission prevalence screening in conjunction with risk factor ascertainment yields important information on the distribution of the MRSA burden for hospitals, and allows for data-based decisions on local or institutional MRSA screening policies considering risk factor prevalence and expected MRSA identification rates.http://europepmc.org/articles/PMC3770647?pdf=render |
| spellingShingle | Mathias Herrmann Christine Petit Alik Dawson Judith Biechele Alexander Halfmann Lutz von Müller Stefan Gräber Stefan Wagenpfeil Renate Klein Barbara Gärtner Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. PLoS ONE |
| title | Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. |
| title_full | Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. |
| title_fullStr | Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. |
| title_full_unstemmed | Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. |
| title_short | Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. |
| title_sort | methicillin resistant staphylococcus aureus in saarland germany a statewide admission prevalence screening study |
| url | http://europepmc.org/articles/PMC3770647?pdf=render |
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