Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior
Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory la...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-06-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/15798 |
| _version_ | 1811181020314075136 |
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| author | Takayuki Yamashita Carl CH Petersen |
| author_facet | Takayuki Yamashita Carl CH Petersen |
| author_sort | Takayuki Yamashita |
| collection | DOAJ |
| description | Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal neurons in primary somatosensory barrel cortex (S1) projecting to either primary motor cortex (M1) or secondary somatosensory cortex (S2) during a whisker detection task, in which thirsty mice learn to lick for water reward in response to a whisker deflection. Whisker stimulation in ‘Good performer’ mice, but not ‘Naive’ mice, evoked long-lasting biphasic depolarization correlated with task performance in S2-projecting (S2-p) neurons, but not M1-projecting (M1-p) neurons. Furthermore, S2-p neurons, but not M1-p neurons, became excited during spontaneous unrewarded licking in ‘Good performer’ mice, but not in ‘Naive’ mice. Thus, a learning-induced, projection-specific signal from S1 to S2 may contribute to goal-directed sensorimotor transformation of whisker sensation into licking motor output. |
| first_indexed | 2024-04-11T09:11:20Z |
| format | Article |
| id | doaj.art-28ef946e3d6844c19d42d935a1e17247 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:11:20Z |
| publishDate | 2016-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-28ef946e3d6844c19d42d935a1e172472022-12-22T04:32:29ZengeLife Sciences Publications LtdeLife2050-084X2016-06-01510.7554/eLife.15798Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behaviorTakayuki Yamashita0https://orcid.org/0000-0002-1849-9837Carl CH Petersen1https://orcid.org/0000-0003-3344-4495Laboratory of Sensory Processing, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, JapanLaboratory of Sensory Processing, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, SwitzerlandGoal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal neurons in primary somatosensory barrel cortex (S1) projecting to either primary motor cortex (M1) or secondary somatosensory cortex (S2) during a whisker detection task, in which thirsty mice learn to lick for water reward in response to a whisker deflection. Whisker stimulation in ‘Good performer’ mice, but not ‘Naive’ mice, evoked long-lasting biphasic depolarization correlated with task performance in S2-projecting (S2-p) neurons, but not M1-projecting (M1-p) neurons. Furthermore, S2-p neurons, but not M1-p neurons, became excited during spontaneous unrewarded licking in ‘Good performer’ mice, but not in ‘Naive’ mice. Thus, a learning-induced, projection-specific signal from S1 to S2 may contribute to goal-directed sensorimotor transformation of whisker sensation into licking motor output.https://elifesciences.org/articles/15798neocortical projection neuronsgoal-directed sensorimotor learningwhole-cell membrane potential recordingsprimary somatosensory barrel cortexsecondary somatosensory cortexwhisker motor cortex |
| spellingShingle | Takayuki Yamashita Carl CH Petersen Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior eLife neocortical projection neurons goal-directed sensorimotor learning whole-cell membrane potential recordings primary somatosensory barrel cortex secondary somatosensory cortex whisker motor cortex |
| title | Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior |
| title_full | Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior |
| title_fullStr | Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior |
| title_full_unstemmed | Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior |
| title_short | Target-specific membrane potential dynamics of neocortical projection neurons during goal-directed behavior |
| title_sort | target specific membrane potential dynamics of neocortical projection neurons during goal directed behavior |
| topic | neocortical projection neurons goal-directed sensorimotor learning whole-cell membrane potential recordings primary somatosensory barrel cortex secondary somatosensory cortex whisker motor cortex |
| url | https://elifesciences.org/articles/15798 |
| work_keys_str_mv | AT takayukiyamashita targetspecificmembranepotentialdynamicsofneocorticalprojectionneuronsduringgoaldirectedbehavior AT carlchpetersen targetspecificmembranepotentialdynamicsofneocorticalprojectionneuronsduringgoaldirectedbehavior |