Synthesis of C7/C8-cyclitols and C7N-aminocyclitols from maltose and X-ray crystal structure of Streptomyces coelicolor GlgEI V279S in a complex with an amylostatin GXG–like derivative

Synthesis of C7/C8-cyclitols and C7N-aminocyclitols from maltose and X-ray crystal structure of Streptomyces coelicolor GlgEI V279S in a complex with an amylostatin GXG–like derivative

C7/C8-cyclitols and C7N-aminocyclitols find applications in the pharmaceutical sector as α-glucosidase inhibitors and in the agricultural sector as fungicides and insecticides. In this study, we identified C7/C8-cyclitols and C7N-aminocyclitols as potential inhibitors of Streptomyces coelicolor (Sco...

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Bibliographic Details
Main Authors: Radhika Thanvi, Thilina D. Jayasinghe, Sunayana Kapil, Babatunde Samuel Obadawo, Donald R. Ronning, Steven J. Sucheck
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Chemistry
Subjects:
C7/C8-cyclitols
C7N-aminocyclitols
enzyme inhibitors
Streptomyces coelicolor GlgEI
protein X-ray structure
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.950433/full

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