Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis
There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/6/1121 |
| _version_ | 1797484248239702016 |
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| author | Konstantinos Tsamakis Sofia Galinaki Evangelos Alevyzakis Ioannis Hortis Dimitrios Tsiptsios Evangelia Kollintza Stylianos Kympouropoulos Konstantinos Triantafyllou Nikolaos Smyrnis Emmanouil Rizos |
| author_facet | Konstantinos Tsamakis Sofia Galinaki Evangelos Alevyzakis Ioannis Hortis Dimitrios Tsiptsios Evangelia Kollintza Stylianos Kympouropoulos Konstantinos Triantafyllou Nikolaos Smyrnis Emmanouil Rizos |
| author_sort | Konstantinos Tsamakis |
| collection | DOAJ |
| description | There is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations. |
| first_indexed | 2024-03-09T22:59:48Z |
| format | Article |
| id | doaj.art-28f236707c334eb0adb595a2a729a550 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T22:59:48Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-28f236707c334eb0adb595a2a729a5502023-11-23T18:03:20ZengMDPI AGMicroorganisms2076-26072022-05-01106112110.3390/microorganisms10061121Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of PsychosisKonstantinos Tsamakis0Sofia Galinaki1Evangelos Alevyzakis2Ioannis Hortis3Dimitrios Tsiptsios4Evangelia Kollintza5Stylianos Kympouropoulos6Konstantinos Triantafyllou7Nikolaos Smyrnis8Emmanouil Rizos9Second Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceHepatogastroenterology Unit, 2nd Department of Propaedeutic Internal Medicine, Medical School, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Psychiatry, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, GreeceThere is a growing body of evidence highlighting the role of gut microbiota as a biological basis of psychiatric disorders. The existing literature suggest that cognitive and emotional activities can be influenced by microbes through the microbiota–gut–brain axis and implies an association between alterations in the gut microbiome and several psychiatric conditions, such as autism, depression, bipolar disorder and psychosis. The aim of this review is to summarise recent findings and provide concise updates on the latest progress of the role of gut microbiota in the development and maintenance of psychiatric symptoms in schizophrenia and the first episode of psychosis. Despite the lack of consistent findings in regard to specific microbiome changes related to psychosis, the emerging literature reports significant differences in the gut microbiome of schizophrenic subjects compared to healthy controls and increasingly outlines the significance of an altered microbiome composition in the pathogenesis, development, symptom severity and prognosis of psychosis. Further human studies are, however, required, which should focus on identifying the drivers of microbiota changes in psychosis and establish the direction of causality between psychosis and microbiome alterations.https://www.mdpi.com/2076-2607/10/6/1121microbiotagutbrainaxispsychopathologypsychosis |
| spellingShingle | Konstantinos Tsamakis Sofia Galinaki Evangelos Alevyzakis Ioannis Hortis Dimitrios Tsiptsios Evangelia Kollintza Stylianos Kympouropoulos Konstantinos Triantafyllou Nikolaos Smyrnis Emmanouil Rizos Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis Microorganisms microbiota gut brain axis psychopathology psychosis |
| title | Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis |
| title_full | Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis |
| title_fullStr | Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis |
| title_full_unstemmed | Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis |
| title_short | Gut Microbiome: A Brief Review on Its Role in Schizophrenia and First Episode of Psychosis |
| title_sort | gut microbiome a brief review on its role in schizophrenia and first episode of psychosis |
| topic | microbiota gut brain axis psychopathology psychosis |
| url | https://www.mdpi.com/2076-2607/10/6/1121 |
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