Oral Delivered Dexmedetomidine Promotes and Consolidates Non-rapid Eye Movement Sleep via Sleep–Wake Regulation Systems in Mice

Oral Delivered Dexmedetomidine Promotes and Consolidates Non-rapid Eye Movement Sleep via Sleep–Wake Regulation Systems in Mice

Dexmedetomidine, a highly selective α2-adrenergic agonist, is widely used in clinical anesthesia and ICU sedation. Recent studies have found that dexmedetomidine-induced sedation resembles the recovery sleep that follows sleep deprivation, but whether orally delivered dexmedetomidine can be a candid...

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Bibliographic Details
Main Authors: Zhen-Xin Feng, Hui Dong, Wei-Min Qu, Wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Pharmacology
Subjects:
dexmedetomidine
LMA
EEG/EMG
sleep–wake
c-Fos
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01196/full

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