Carnosine restores the activation of signaling cascades and the ratio of apoptosis-regulating proteins in the penumbra zone after a permanent focal cerebral ischemia in rats

Carnosine restores the activation of signaling cascades and the ratio of apoptosis-regulating proteins in the penumbra zone after a permanent focal cerebral ischemia in rats

Abstract Introduction. Ischemic stroke is one of the most common and socially significant diseases, and its pathogenesis is associated with oxidative stress. The study of mechanisms of the neuroprotective action of the natural antioxidant carnosine is promising in the context of carnosine-based d...

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Bibliographic Details
Main Authors: Olga M. Lopacheva, Alexander V. Lopachev, Kseniya N. Kulichenkova, Alexander A. Devyatov, Daniil S. Berezhnoy, Sergey L. Stvolinsky, Olga I. Kulikova, Svetlana A. Gavrilova, Mariya P. Morozova, Tatiana N. Fedorova
Format: Article
Language:English
Published: Research Center of Neurology 2018-03-01
Series:Анналы клинической и экспериментальной неврологии
Subjects:
carnosine
permanent focal cerebral ischemia
ischemic penumbra
bcl-2 family
akt
map kinases
Online Access:https://annaly-nevrologii.com/journal/pathID/article/viewFile/512/403

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