Combination treatment of perifosine and valsartan showed more efficiency in protecting against pressure overload induced mouse heart failure

Combination treatment of perifosine and valsartan showed more efficiency in protecting against pressure overload induced mouse heart failure

The optimum strategy for heart failure (HF) treatment has yet to be elucidated. This study intended to test the benefit of a combination of valsartan (VAL) and perifosine (PER), a specific AKT inhibitor, in protecting against pressure overload induced mouse HF. Mouse were subjected to aortic banding...

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Bibliographic Details
Main Authors: Wen-jing Li, Hai-han Liao, Hong Feng, Zi-ying Zhou, Shan-qi Mou, Nan Zhang, Hai-ming Wu, Hao Xia, Qi-zhu Tang
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Valsartan
Perifosine
Heart failure
Akt
ERK1/2
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300360

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