Diuretics in patients with metabolic disturbances
Aim. To study antihypertensive effectiveness of indapamide retard, its effects on carbohydrate, lipid, purine, electrolyte metabolism in patients with mild arterial hypertension (AH) and metabolic syndrome (MS). Material and methods. The study included three phases: initial (screening), 12-week acti...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2007-04-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1189 |
| _version_ | 1827064074333061120 |
|---|---|
| author | I. E. Chazova V. B. Mychka |
| author_facet | I. E. Chazova V. B. Mychka |
| author_sort | I. E. Chazova |
| collection | DOAJ |
| description | Aim. To study antihypertensive effectiveness of indapamide retard, its effects on carbohydrate, lipid, purine, electrolyte metabolism in patients with mild arterial hypertension (AH) and metabolic syndrome (MS). Material and methods. The study included three phases: initial (screening), 12-week active treatment, and 36-week self-control phase. In total, 619 patients were randomized into two groups. Active treatment group received indapamide retard combined with non4pharmaceutical weight reduction measures; control group received non-pharmaceutical intervention only. At baseline, total cholesterol (CH), low-density lipoprotein CH (LDL-CH), uricacid, potassium, sodium levels were measured; glucose tolerance test was performed. After active treatment phase, all patients receiving indapamide retard and achieving target blood pressure (BP) levels were recommended to continue the treatment under self-control. Individuals failing to achieve target BP levels were recommended to take perindopril in addition. If needed, control group patients were also administered antihypertensive therapy. Results. After 12-week therapy, target BP levels were achieved in 61,8% of patients receiving indapamide retard, and 48,4% participants of control group; after 12 months - in 69,4% and 52,7%, respectively. Body weight significantly reduced in both groups, by 3 kg on average, waist circumference - by 3 cm. Carbohydrate and lipid metabolism parameters also improved: in 37% of active treatment patients and 25,2% of control group individuals glucose tolerance improved, atherogenicity index decreased. Indapamide retard therapy was well tolerated. Conclusion. Indapamide retard demonstrated good antihypertensive effectiveness and beneficial effects on carbohydrate and lipid metabolism in MS patients. |
| first_indexed | 2024-04-10T03:40:20Z |
| format | Article |
| id | doaj.art-28f53da28bb04b43bb0a3e17e0ec5cea |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:41:22Z |
| publishDate | 2007-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-28f53da28bb04b43bb0a3e17e0ec5cea2024-10-17T12:21:24Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-04-01622833901Diuretics in patients with metabolic disturbancesI. E. Chazova0V. B. Mychka1A.L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowA.L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, MoscowAim. To study antihypertensive effectiveness of indapamide retard, its effects on carbohydrate, lipid, purine, electrolyte metabolism in patients with mild arterial hypertension (AH) and metabolic syndrome (MS). Material and methods. The study included three phases: initial (screening), 12-week active treatment, and 36-week self-control phase. In total, 619 patients were randomized into two groups. Active treatment group received indapamide retard combined with non4pharmaceutical weight reduction measures; control group received non-pharmaceutical intervention only. At baseline, total cholesterol (CH), low-density lipoprotein CH (LDL-CH), uricacid, potassium, sodium levels were measured; glucose tolerance test was performed. After active treatment phase, all patients receiving indapamide retard and achieving target blood pressure (BP) levels were recommended to continue the treatment under self-control. Individuals failing to achieve target BP levels were recommended to take perindopril in addition. If needed, control group patients were also administered antihypertensive therapy. Results. After 12-week therapy, target BP levels were achieved in 61,8% of patients receiving indapamide retard, and 48,4% participants of control group; after 12 months - in 69,4% and 52,7%, respectively. Body weight significantly reduced in both groups, by 3 kg on average, waist circumference - by 3 cm. Carbohydrate and lipid metabolism parameters also improved: in 37% of active treatment patients and 25,2% of control group individuals glucose tolerance improved, atherogenicity index decreased. Indapamide retard therapy was well tolerated. Conclusion. Indapamide retard demonstrated good antihypertensive effectiveness and beneficial effects on carbohydrate and lipid metabolism in MS patients.https://cardiovascular.elpub.ru/jour/article/view/1189metabolic syndromearterial hypertensiontreatmentindapamide retard |
| spellingShingle | I. E. Chazova V. B. Mychka Diuretics in patients with metabolic disturbances Кардиоваскулярная терапия и профилактика metabolic syndrome arterial hypertension treatment indapamide retard |
| title | Diuretics in patients with metabolic disturbances |
| title_full | Diuretics in patients with metabolic disturbances |
| title_fullStr | Diuretics in patients with metabolic disturbances |
| title_full_unstemmed | Diuretics in patients with metabolic disturbances |
| title_short | Diuretics in patients with metabolic disturbances |
| title_sort | diuretics in patients with metabolic disturbances |
| topic | metabolic syndrome arterial hypertension treatment indapamide retard |
| url | https://cardiovascular.elpub.ru/jour/article/view/1189 |
| work_keys_str_mv | AT iechazova diureticsinpatientswithmetabolicdisturbances AT vbmychka diureticsinpatientswithmetabolicdisturbances |