MRONJ Treatment Strategies: A Systematic Review and Two Case Reports
MRONJ is a serious drug-related side effect that is most common in people using antiresorptive and/or angiogenic medications. Therapy options for this condition include conservative treatments, surgical procedures with varied degrees of invasiveness, and adjuvant therapies. The aim of the present st...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/7/4370 |
| _version_ | 1797608307327762432 |
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| author | Angelo Michele Inchingolo Giuseppina Malcangi Irene Ferrara Assunta Patano Fabio Viapiano Anna Netti Daniela Azzollini Anna Maria Ciocia Elisabetta de Ruvo Merigrazia Campanelli Pasquale Avantario Antonio Mancini Francesco Inchingolo Ciro Gargiulo Isacco Alberto Corriero Alessio Danilo Inchingolo Gianna Dipalma |
| author_facet | Angelo Michele Inchingolo Giuseppina Malcangi Irene Ferrara Assunta Patano Fabio Viapiano Anna Netti Daniela Azzollini Anna Maria Ciocia Elisabetta de Ruvo Merigrazia Campanelli Pasquale Avantario Antonio Mancini Francesco Inchingolo Ciro Gargiulo Isacco Alberto Corriero Alessio Danilo Inchingolo Gianna Dipalma |
| author_sort | Angelo Michele Inchingolo |
| collection | DOAJ |
| description | MRONJ is a serious drug-related side effect that is most common in people using antiresorptive and/or angiogenic medications. Therapy options for this condition include conservative treatments, surgical procedures with varied degrees of invasiveness, and adjuvant therapies. The aim of the present study is to identify the most successful and promising therapy alternatives available to clinicians. PubMed, Cochrane, Scopus, Web of Science, and Embase were searched for works on our topic published between 8 January 2006 and 8 January 2023. The search was restricted to randomized clinical trials, retrospective studies, clinical studies, and case series involving human subjects with at least five cases and no age restriction on participants. A total of 2657 was found. After the selection process, the review included 32 publications for qualitative analysis. Although conservative treatments (pharmacological, laser, and minimally invasive surgery) are effective in the early stages of MRONJs or as a supplement to traditional surgical resection therapy, most studies emphasize the importance of surgical treatment for the resolution or downstaging of advanced lesions. Fluorescence-guided surgery, PRP, PRF, CGF, piezosurgery, VEGF, hyaluronic acid, and ozone therapy all show significant potential for improving treatment outcomes. |
| first_indexed | 2024-03-11T05:42:38Z |
| format | Article |
| id | doaj.art-28f5444d32ba49609549fac47b9b5703 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-11T05:42:38Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-28f5444d32ba49609549fac47b9b57032023-11-17T16:19:23ZengMDPI AGApplied Sciences2076-34172023-03-01137437010.3390/app13074370MRONJ Treatment Strategies: A Systematic Review and Two Case ReportsAngelo Michele Inchingolo0Giuseppina Malcangi1Irene Ferrara2Assunta Patano3Fabio Viapiano4Anna Netti5Daniela Azzollini6Anna Maria Ciocia7Elisabetta de Ruvo8Merigrazia Campanelli9Pasquale Avantario10Antonio Mancini11Francesco Inchingolo12Ciro Gargiulo Isacco13Alberto Corriero14Alessio Danilo Inchingolo15Gianna Dipalma16Department of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyMRONJ is a serious drug-related side effect that is most common in people using antiresorptive and/or angiogenic medications. Therapy options for this condition include conservative treatments, surgical procedures with varied degrees of invasiveness, and adjuvant therapies. The aim of the present study is to identify the most successful and promising therapy alternatives available to clinicians. PubMed, Cochrane, Scopus, Web of Science, and Embase were searched for works on our topic published between 8 January 2006 and 8 January 2023. The search was restricted to randomized clinical trials, retrospective studies, clinical studies, and case series involving human subjects with at least five cases and no age restriction on participants. A total of 2657 was found. After the selection process, the review included 32 publications for qualitative analysis. Although conservative treatments (pharmacological, laser, and minimally invasive surgery) are effective in the early stages of MRONJs or as a supplement to traditional surgical resection therapy, most studies emphasize the importance of surgical treatment for the resolution or downstaging of advanced lesions. Fluorescence-guided surgery, PRP, PRF, CGF, piezosurgery, VEGF, hyaluronic acid, and ozone therapy all show significant potential for improving treatment outcomes.https://www.mdpi.com/2076-3417/13/7/4370MRONJosteonecrosisdenosumabDRONJconcentrated growth factorplatelet-rich plasma |
| spellingShingle | Angelo Michele Inchingolo Giuseppina Malcangi Irene Ferrara Assunta Patano Fabio Viapiano Anna Netti Daniela Azzollini Anna Maria Ciocia Elisabetta de Ruvo Merigrazia Campanelli Pasquale Avantario Antonio Mancini Francesco Inchingolo Ciro Gargiulo Isacco Alberto Corriero Alessio Danilo Inchingolo Gianna Dipalma MRONJ Treatment Strategies: A Systematic Review and Two Case Reports Applied Sciences MRONJ osteonecrosis denosumab DRONJ concentrated growth factor platelet-rich plasma |
| title | MRONJ Treatment Strategies: A Systematic Review and Two Case Reports |
| title_full | MRONJ Treatment Strategies: A Systematic Review and Two Case Reports |
| title_fullStr | MRONJ Treatment Strategies: A Systematic Review and Two Case Reports |
| title_full_unstemmed | MRONJ Treatment Strategies: A Systematic Review and Two Case Reports |
| title_short | MRONJ Treatment Strategies: A Systematic Review and Two Case Reports |
| title_sort | mronj treatment strategies a systematic review and two case reports |
| topic | MRONJ osteonecrosis denosumab DRONJ concentrated growth factor platelet-rich plasma |
| url | https://www.mdpi.com/2076-3417/13/7/4370 |
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