Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2
Background: Malondialdehyde (MDA) levels produced by oxidative stress in type 2 diabetes mellitus (T2DM) is higher than in non diabetes patients. Vitamin C and E inhibit oxidative stress and MDA production. The purpose of this study was to prove the effects of combined vitamin C and vitamin E on MDA...
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| Format: | Article |
| Language: | Indonesian |
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Diponegoro University
2016-12-01
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| Series: | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| Subjects: | |
| Online Access: | https://ejournal.undip.ac.id/index.php/jgi/article/view/12321 |
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| author | Yade Kurnia Yasin Martha Irene Kartasurya RA Kisdjamiatun RMD |
| author_facet | Yade Kurnia Yasin Martha Irene Kartasurya RA Kisdjamiatun RMD |
| author_sort | Yade Kurnia Yasin |
| collection | DOAJ |
| description | Background: Malondialdehyde (MDA) levels produced by oxidative stress in type 2 diabetes mellitus (T2DM) is higher than in non diabetes patients. Vitamin C and E inhibit oxidative stress and MDA production. The purpose of this study was to prove the effects of combined vitamin C and vitamin E on MDA plasma levels in T2DM patients.
Methods: This double blind randomized pre post test control group design was carried out on 35 patients with T2DM without complication (age 40-60 yr) in Makassar. The treatment group (n=18) received vitamin C 250 mg/day plus vitamin E 400 IU/day and the control group (n=17) received placebo (seaweed powder 250 mg), for six weeks. Vitamin C was consumed before meal and vitamin E after meal. MDA levels were measured before and after supplementation by using TBARs method. Food intake and activity were derived from 24-hour recall method.
Results: There was no different on MDA levels at baseline (p=0.151). At the end of the study, MDA levels increased in control group (5.8±2.74 to 7.2±3.00 nmol/ml; p=0.044) but not in the treatment group (7.2±2.88 to 7.7±2.02 nmol/ml; p=0.490). There was no difference in MDA alteration between the goups (p=0.316). There was no different in MDA levels at the end of the study (p=0.061) and confirmed after controlling the confounding variables: vitamin E intake and fasting blood glucose (p=0.809).
Conclusion: Combined vitamin C 250 mg and vitamin E 400 IU for 6 weeks did not reduce MDA levels, but inhibit MDA production in T2DM patients. |
| first_indexed | 2024-12-23T05:51:53Z |
| format | Article |
| id | doaj.art-28f55c7e174743c1b173ec7b70b7cbb8 |
| institution | Directory Open Access Journal |
| issn | 1858-4942 2338-3119 |
| language | Indonesian |
| last_indexed | 2024-12-23T05:51:53Z |
| publishDate | 2016-12-01 |
| publisher | Diponegoro University |
| record_format | Article |
| series | Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition |
| spelling | doaj.art-28f55c7e174743c1b173ec7b70b7cbb82022-12-21T17:57:55ZindDiponegoro UniversityJurnal Gizi Indonesia: The Indonesian Journal of Nutrition1858-49422338-31192016-12-01411810.14710/jgi.4.1.1-89701Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2Yade Kurnia Yasin0Martha Irene Kartasurya1RA Kisdjamiatun RMD2Politeknik Kesehatan Kemenkes GorontaloFakultas Kesehatan Masyarakat, Universitas DiponegoroFakultas Kesehatan Masyarakat, Universitas DiponegoroBackground: Malondialdehyde (MDA) levels produced by oxidative stress in type 2 diabetes mellitus (T2DM) is higher than in non diabetes patients. Vitamin C and E inhibit oxidative stress and MDA production. The purpose of this study was to prove the effects of combined vitamin C and vitamin E on MDA plasma levels in T2DM patients. Methods: This double blind randomized pre post test control group design was carried out on 35 patients with T2DM without complication (age 40-60 yr) in Makassar. The treatment group (n=18) received vitamin C 250 mg/day plus vitamin E 400 IU/day and the control group (n=17) received placebo (seaweed powder 250 mg), for six weeks. Vitamin C was consumed before meal and vitamin E after meal. MDA levels were measured before and after supplementation by using TBARs method. Food intake and activity were derived from 24-hour recall method. Results: There was no different on MDA levels at baseline (p=0.151). At the end of the study, MDA levels increased in control group (5.8±2.74 to 7.2±3.00 nmol/ml; p=0.044) but not in the treatment group (7.2±2.88 to 7.7±2.02 nmol/ml; p=0.490). There was no difference in MDA alteration between the goups (p=0.316). There was no different in MDA levels at the end of the study (p=0.061) and confirmed after controlling the confounding variables: vitamin E intake and fasting blood glucose (p=0.809). Conclusion: Combined vitamin C 250 mg and vitamin E 400 IU for 6 weeks did not reduce MDA levels, but inhibit MDA production in T2DM patients.https://ejournal.undip.ac.id/index.php/jgi/article/view/12321MalondialdehidVitamin CVitamin EDiabetes Mellitus Tipe 2 |
| spellingShingle | Yade Kurnia Yasin Martha Irene Kartasurya RA Kisdjamiatun RMD Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 Jurnal Gizi Indonesia: The Indonesian Journal of Nutrition Malondialdehid Vitamin C Vitamin E Diabetes Mellitus Tipe 2 |
| title | Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 |
| title_full | Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 |
| title_fullStr | Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 |
| title_full_unstemmed | Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 |
| title_short | Pengaruh kombinasi vitamin c dan vitamin e terhadap Kadar malondialdehid plasma pasien diabetes mellitus tipe 2 |
| title_sort | pengaruh kombinasi vitamin c dan vitamin e terhadap kadar malondialdehid plasma pasien diabetes mellitus tipe 2 |
| topic | Malondialdehid Vitamin C Vitamin E Diabetes Mellitus Tipe 2 |
| url | https://ejournal.undip.ac.id/index.php/jgi/article/view/12321 |
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