Atorvastatin Attenuates Isoflurane-Induced Activation of ROS-p38MAPK/ATF2 Pathway, Neuronal Degeneration, and Cognitive Impairment of the Aged Mice

Atorvastatin Attenuates Isoflurane-Induced Activation of ROS-p38MAPK/ATF2 Pathway, Neuronal Degeneration, and Cognitive Impairment of the Aged Mice

Isoflurane, a widely used volatile anesthetic, induces neuronal apoptosis and memory impairments in various animal models. However, the potential mechanisms and effective pharmacologic agents are still not fully understood. The p38MAPK/ATF-2 pathway has been proved to regulate neuronal cell survival...

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Bibliographic Details
Main Authors: Pengfei Liu, Quansheng Gao, Lei Guan, Weixuan Sheng, Yanting Hu, Teng Gao, Jingwen Jiang, Yongxing Xu, Hui Qiao, Xinying Xue, Sanhong Liu, Tianzuo Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
mitogen activated protein kinases
neuronal degeneration
reactive oxygen species
isoflurane
atorvastatin
aging
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.620946/full

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