Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer
Abstract Background Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PS...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-02-01
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| Series: | EJNMMI Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13550-020-0596-4 |
| _version_ | 1818294366447337472 |
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| author | Céline Derwael Olivier Lavergne Pierre Lovinfosse Vlad Nechifor Mallory Salvé David Waltregny Roland Hustinx Nadia Withofs |
| author_facet | Céline Derwael Olivier Lavergne Pierre Lovinfosse Vlad Nechifor Mallory Salvé David Waltregny Roland Hustinx Nadia Withofs |
| author_sort | Céline Derwael |
| collection | DOAJ |
| description | Abstract Background Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation according to PC molecular imaging standardized evaluation (PROMISE) criteria and reproducibility of PSMA reporting and data systems (RADS). Methods Forty-three patients with newly diagnosed, histologically proven intermediate- or high-risk PC, eligible for radical prostatectomy and who underwent [68Ga]Ga-PSMA-11 PET/CT before surgery were retrospectively included. Three nuclear medicine physicians (2 experienced and 1 resident) independently reviewed PET/CT images. Interpretation of [68Ga]Ga-PSMA-11 PET/CT images was based on PROMISE criteria including miTNM staging and lesions miPSMA expression score visual estimation and PSMA-RADS version 1.0 for a given scan. Readers’ agreement was measured using Krippendorff’s coefficients Results Agreement between observers was almost perfect (coefficient ≥ 0.81) for miM; it was substantial (coefficient ≥ 0.61) for the following criteria: miT, miN, PSMA-RADS, and miPSMA expression score of primary PC lesion and metastases. However, agreement was moderate (coefficient = 0.41–0.60) for miPSMA score of positive lymph nodes and for detection of PC primary lesion. Conclusion Visual interpretation of [68Ga]Ga-PSMA-11 PET/CT images in patients with newly diagnosed PC in a clinical setting leads to at least substantial agreement for PROMISE criteria and PSMA-RADS classification except for PC primary lesion detection and for miPSMA expression scoring of positive lymph nodes that might have been hampered by the interindividual variability of reference organs PSMA expression. |
| first_indexed | 2024-12-13T03:30:36Z |
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| id | doaj.art-28f7e107398e49b1aedb3dccd9dc3d61 |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-13T03:30:36Z |
| publishDate | 2020-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-28f7e107398e49b1aedb3dccd9dc3d612022-12-22T00:01:10ZengSpringerOpenEJNMMI Research2191-219X2020-02-0110111010.1186/s13550-020-0596-4Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancerCéline Derwael0Olivier Lavergne1Pierre Lovinfosse2Vlad Nechifor3Mallory Salvé4David Waltregny5Roland Hustinx6Nadia Withofs7Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, CHU of LiegeDepartment of Urology, CHR of LiegeDivision of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, CHU of LiegeDepartment of Urology, CHU of LiegeDivision of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, CHU of LiegeDepartment of Urology, CHU of LiegeDivision of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, CHU of LiegeDivision of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, CHU of LiegeAbstract Background Prostate-specific membrane antigen (PSMA) ligand PET/CT has already provided promising results in prostate cancer (PC) imaging, yet simple and reproductible reporting criteria are still lacking. This study aimed at retrospectively evaluating interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation according to PC molecular imaging standardized evaluation (PROMISE) criteria and reproducibility of PSMA reporting and data systems (RADS). Methods Forty-three patients with newly diagnosed, histologically proven intermediate- or high-risk PC, eligible for radical prostatectomy and who underwent [68Ga]Ga-PSMA-11 PET/CT before surgery were retrospectively included. Three nuclear medicine physicians (2 experienced and 1 resident) independently reviewed PET/CT images. Interpretation of [68Ga]Ga-PSMA-11 PET/CT images was based on PROMISE criteria including miTNM staging and lesions miPSMA expression score visual estimation and PSMA-RADS version 1.0 for a given scan. Readers’ agreement was measured using Krippendorff’s coefficients Results Agreement between observers was almost perfect (coefficient ≥ 0.81) for miM; it was substantial (coefficient ≥ 0.61) for the following criteria: miT, miN, PSMA-RADS, and miPSMA expression score of primary PC lesion and metastases. However, agreement was moderate (coefficient = 0.41–0.60) for miPSMA score of positive lymph nodes and for detection of PC primary lesion. Conclusion Visual interpretation of [68Ga]Ga-PSMA-11 PET/CT images in patients with newly diagnosed PC in a clinical setting leads to at least substantial agreement for PROMISE criteria and PSMA-RADS classification except for PC primary lesion detection and for miPSMA expression scoring of positive lymph nodes that might have been hampered by the interindividual variability of reference organs PSMA expression.http://link.springer.com/article/10.1186/s13550-020-0596-4Interobserver agreementPSMA-RADSPROMISEmiTNMPSMA PETStandardized evaluation |
| spellingShingle | Céline Derwael Olivier Lavergne Pierre Lovinfosse Vlad Nechifor Mallory Salvé David Waltregny Roland Hustinx Nadia Withofs Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer EJNMMI Research Interobserver agreement PSMA-RADS PROMISE miTNM PSMA PET Standardized evaluation |
| title | Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer |
| title_full | Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer |
| title_fullStr | Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer |
| title_full_unstemmed | Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer |
| title_short | Interobserver agreement of [68Ga]Ga-PSMA-11 PET/CT images interpretation in men with newly diagnosed prostate cancer |
| title_sort | interobserver agreement of 68ga ga psma 11 pet ct images interpretation in men with newly diagnosed prostate cancer |
| topic | Interobserver agreement PSMA-RADS PROMISE miTNM PSMA PET Standardized evaluation |
| url | http://link.springer.com/article/10.1186/s13550-020-0596-4 |
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