Interleukin-8 (IL-8) as a Potential Mediator of an Association between Trimethylamine N-Oxide (TMAO) and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) among African Americans at Risk of Cardiovascular Disease

Interleukin-8 (IL-8) as a Potential Mediator of an Association between Trimethylamine N-Oxide (TMAO) and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) among African Americans at Risk of Cardiovascular Disease

Trimethylamine N-oxide (TMAO)—a microbial metabolite derived from the hepatic–gut axis—is linked to inflammation, hyperlipidemia, and cardiovascular disease (CVD). Proprotein convertase subtilisin/kexin type 9 (PCSK9), which is largely hepatically expressed, blocks low-density lipoprotein (LDL) rece...

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Bibliographic Details
Main Authors: Alyssa M. Baginski, Nicole Farmer, Yvonne Baumer, Gwenyth R. Wallen, Tiffany M. Powell-Wiley
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Metabolites
Subjects:
cardiovascular disease
TMAO
PCSK9
inflammation
Online Access:https://www.mdpi.com/2218-1989/12/12/1196

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