Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments
In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2009-03-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108002775 |
| _version_ | 1818573083385004032 |
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| author | Carla Cunha Andrea Angelucci Angela D'Antoni Mate D. Dobrossy Stephen B. Dunnett Nicoletta Berardi Riccardo Brambilla |
| author_facet | Carla Cunha Andrea Angelucci Angela D'Antoni Mate D. Dobrossy Stephen B. Dunnett Nicoletta Berardi Riccardo Brambilla |
| author_sort | Carla Cunha |
| collection | DOAJ |
| description | In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation. |
| first_indexed | 2024-12-15T00:06:21Z |
| format | Article |
| id | doaj.art-28f8f48c1d4140c3966d97d109ba180a |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-15T00:06:21Z |
| publishDate | 2009-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-28f8f48c1d4140c3966d97d109ba180a2022-12-21T22:42:42ZengElsevierNeurobiology of Disease1095-953X2009-03-01333358368Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairmentsCarla Cunha0Andrea Angelucci1Angela D'Antoni2Mate D. Dobrossy3Stephen B. Dunnett4Nicoletta Berardi5Riccardo Brambilla6San Raffaele Scientific Institute, Milan, Italy; Faculdade de Ciências da Universidade do Porto, PortugalInstitute of Neuroscience of CNR, Pisa, ItalySan Raffaele Scientific Institute, Milan, Italy; University of Milan, ItalySchool of Biosciences, Cardiff, UKSchool of Biosciences, Cardiff, UKInstitute of Neuroscience of CNR, Pisa, Italy; Department of Psychology, Florence University, Florence, ItalySan Raffaele Scientific Institute, Milan, Italy; Corresponding author. Fax: +39 0226434767.In this study we analyzed the effect on behavior of a chronic exposure to brain-derived neurotrophic factor (BDNF), by analysing a mouse line overexpressing BDNF under the αCaMKII promoter, which drives the transgene expression exclusively to principal neurons of the forebrain. BDNF transgenic mice and their WT littermates were examined with a battery of behavioral tests, in order to evaluate motor coordination, learning, short and long-term memory formation. Our results demonstrate that chronic BDNF overexpression in the central nervous system (CNS) causes learning deficits and short-term memory impairments, both in spatial and instrumental learning tasks. This observation suggests that a widespread increase in BDNF in forebrain networks may result in adverse effects on learning and memory formation.http://www.sciencedirect.com/science/article/pii/S0969996108002775BDNFSpatial learningPassive avoidanceShort-term memory |
| spellingShingle | Carla Cunha Andrea Angelucci Angela D'Antoni Mate D. Dobrossy Stephen B. Dunnett Nicoletta Berardi Riccardo Brambilla Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments Neurobiology of Disease BDNF Spatial learning Passive avoidance Short-term memory |
| title | Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments |
| title_full | Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments |
| title_fullStr | Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments |
| title_full_unstemmed | Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments |
| title_short | Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments |
| title_sort | brain derived neurotrophic factor bdnf overexpression in the forebrain results in learning and memory impairments |
| topic | BDNF Spatial learning Passive avoidance Short-term memory |
| url | http://www.sciencedirect.com/science/article/pii/S0969996108002775 |
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