Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis
Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear. Type 2 alveolar epithelial cells (AT2), the essential cells that maintain the structure and function of lung tissue, are...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.999600/full |
| _version_ | 1811326690302885888 |
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| author | Shenghui Zhou Shenghui Zhou Jiaojiao Zhu Ping-Kun Zhou Ping-Kun Zhou Yongqing Gu Yongqing Gu |
| author_facet | Shenghui Zhou Shenghui Zhou Jiaojiao Zhu Ping-Kun Zhou Ping-Kun Zhou Yongqing Gu Yongqing Gu |
| author_sort | Shenghui Zhou |
| collection | DOAJ |
| description | Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear. Type 2 alveolar epithelial cells (AT2), the essential cells that maintain the structure and function of lung tissue, are crucial for developing pulmonary fibrosis. Recent studies indicate the critical role of AT2 cell senescence during the onset and progression of RIPF. In addition, clearance of senescent AT2 cells and treatment with senolytic drugs efficiently improve lung function and radiation-induced pulmonary fibrosis symptoms. These findings indicate that AT2 cell senescence has the potential to contribute significantly to the innovative treatment of fibrotic lung disorders. This review summarizes the current knowledge from basic and clinical research about the mechanism and functions of AT2 cell senescence in RIPF and points to the prospects for clinical treatment by targeting senescent AT2 cells. |
| first_indexed | 2024-04-13T14:54:12Z |
| format | Article |
| id | doaj.art-28fa4b4c43084de180b18f768169ea64 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T14:54:12Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-28fa4b4c43084de180b18f768169ea642022-12-22T02:42:30ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-11-011010.3389/fcell.2022.999600999600Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosisShenghui Zhou0Shenghui Zhou1Jiaojiao Zhu2Ping-Kun Zhou3Ping-Kun Zhou4Yongqing Gu5Yongqing Gu6Hengyang Medical College, University of South China, Hengyang, ChinaBeijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, ChinaBeijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, ChinaHengyang Medical College, University of South China, Hengyang, ChinaBeijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, ChinaHengyang Medical College, University of South China, Hengyang, ChinaBeijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, AMMS, Beijing, ChinaRadiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear. Type 2 alveolar epithelial cells (AT2), the essential cells that maintain the structure and function of lung tissue, are crucial for developing pulmonary fibrosis. Recent studies indicate the critical role of AT2 cell senescence during the onset and progression of RIPF. In addition, clearance of senescent AT2 cells and treatment with senolytic drugs efficiently improve lung function and radiation-induced pulmonary fibrosis symptoms. These findings indicate that AT2 cell senescence has the potential to contribute significantly to the innovative treatment of fibrotic lung disorders. This review summarizes the current knowledge from basic and clinical research about the mechanism and functions of AT2 cell senescence in RIPF and points to the prospects for clinical treatment by targeting senescent AT2 cells.https://www.frontiersin.org/articles/10.3389/fcell.2022.999600/fullradiation-induced pulmonary fibrosistype 2 alveolar epithelial cellscellular senescencesenescence associated secretory phenotypetherapy |
| spellingShingle | Shenghui Zhou Shenghui Zhou Jiaojiao Zhu Ping-Kun Zhou Ping-Kun Zhou Yongqing Gu Yongqing Gu Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis Frontiers in Cell and Developmental Biology radiation-induced pulmonary fibrosis type 2 alveolar epithelial cells cellular senescence senescence associated secretory phenotype therapy |
| title | Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis |
| title_full | Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis |
| title_fullStr | Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis |
| title_full_unstemmed | Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis |
| title_short | Alveolar type 2 epithelial cell senescence and radiation-induced pulmonary fibrosis |
| title_sort | alveolar type 2 epithelial cell senescence and radiation induced pulmonary fibrosis |
| topic | radiation-induced pulmonary fibrosis type 2 alveolar epithelial cells cellular senescence senescence associated secretory phenotype therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.999600/full |
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