The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents.
The question of whether attention-related disorders such as attention-deficit/hyperactivity disorder (ADHD) are best understood as clinical categories or as extreme ends of a spectrum is an ongoing debate. Assessing individuals with varying degrees of attention problems and utilizing novel methodolo...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0279260 |
| _version_ | 1797942931828506624 |
|---|---|
| author | Halima Rafi Farnaz Delavari Nader Perroud Mélodie Derome Martin Debbané |
| author_facet | Halima Rafi Farnaz Delavari Nader Perroud Mélodie Derome Martin Debbané |
| author_sort | Halima Rafi |
| collection | DOAJ |
| description | The question of whether attention-related disorders such as attention-deficit/hyperactivity disorder (ADHD) are best understood as clinical categories or as extreme ends of a spectrum is an ongoing debate. Assessing individuals with varying degrees of attention problems and utilizing novel methodologies to assess relationships between attention and brain activity may provide key information to support the spectrum hypothesis. We scanned 91 neurotypical adolescents during rest using functional magnetic resonance imaging. We conducted static and dynamic functional network connectivity (FNC) analysis and correlated findings to behavioral metrics of ADHD, attention problems, and impulsivity. We found that dynamic FNC analysis detects significant differences in large-scale neural connectivity as a function of individual differences in attention and impulsivity that are obscured in static analysis. We show ADHD manifestations and attention problems are associated with diminished Salience Network-centered FNC and that ADHD manifestations and impulsivity are associated with prolonged periods of dynamically hyperconnected states. Importantly, our meta-state analysis results reveal a relationship between ADHD manifestations and exhibiting variable and volatile dynamic behavior such as changing meta-states more often and traveling over a greater dynamic range. These findings in non-clinical adolescents provide support for the continuum model of attention disorders. |
| first_indexed | 2024-04-10T20:15:19Z |
| format | Article |
| id | doaj.art-28fc3e1af3fc43849532fd6e70eb09c2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T20:15:19Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-28fc3e1af3fc43849532fd6e70eb09c22023-01-26T05:32:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181e027926010.1371/journal.pone.0279260The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents.Halima RafiFarnaz DelavariNader PerroudMélodie DeromeMartin DebbanéThe question of whether attention-related disorders such as attention-deficit/hyperactivity disorder (ADHD) are best understood as clinical categories or as extreme ends of a spectrum is an ongoing debate. Assessing individuals with varying degrees of attention problems and utilizing novel methodologies to assess relationships between attention and brain activity may provide key information to support the spectrum hypothesis. We scanned 91 neurotypical adolescents during rest using functional magnetic resonance imaging. We conducted static and dynamic functional network connectivity (FNC) analysis and correlated findings to behavioral metrics of ADHD, attention problems, and impulsivity. We found that dynamic FNC analysis detects significant differences in large-scale neural connectivity as a function of individual differences in attention and impulsivity that are obscured in static analysis. We show ADHD manifestations and attention problems are associated with diminished Salience Network-centered FNC and that ADHD manifestations and impulsivity are associated with prolonged periods of dynamically hyperconnected states. Importantly, our meta-state analysis results reveal a relationship between ADHD manifestations and exhibiting variable and volatile dynamic behavior such as changing meta-states more often and traveling over a greater dynamic range. These findings in non-clinical adolescents provide support for the continuum model of attention disorders.https://doi.org/10.1371/journal.pone.0279260 |
| spellingShingle | Halima Rafi Farnaz Delavari Nader Perroud Mélodie Derome Martin Debbané The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents. PLoS ONE |
| title | The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents. |
| title_full | The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents. |
| title_fullStr | The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents. |
| title_full_unstemmed | The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents. |
| title_short | The continuum of attention dysfunction: Evidence from dynamic functional network connectivity analysis in neurotypical adolescents. |
| title_sort | continuum of attention dysfunction evidence from dynamic functional network connectivity analysis in neurotypical adolescents |
| url | https://doi.org/10.1371/journal.pone.0279260 |
| work_keys_str_mv | AT halimarafi thecontinuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT farnazdelavari thecontinuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT naderperroud thecontinuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT melodiederome thecontinuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT martindebbane thecontinuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT halimarafi continuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT farnazdelavari continuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT naderperroud continuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT melodiederome continuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents AT martindebbane continuumofattentiondysfunctionevidencefromdynamicfunctionalnetworkconnectivityanalysisinneurotypicaladolescents |