Smad1 Expression in Follicular Lymphoma
Background: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2015-05-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-49-3-243.pdf |
| _version_ | 1818055034168934400 |
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| author | Jai Hyang Go |
| author_facet | Jai Hyang Go |
| author_sort | Jai Hyang Go |
| collection | DOAJ |
| description | Background: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be overexpressed in follicular lymphoma, but little is known regarding the expression patterns of Smad proteins in human lymphoid tissue. Methods: In the present study, we performed immunohistochemistry for traditional germinal center markers and for Smad1 in human reactive lymphoid and follicular lymphoma tissues to investigate Smad1’s usefulness in the diagnosis of follicular lymphoma. Results: In the reactive germinal centers, most cells were positive for Smad1. Among the 27 follicular lymphoma cases, 17 of 21 (80%) were Smad1 positive, 17 of 27 (63%) were positive for CD10, and 23 of 27 (85%) were positive for Bcl6. Notably, three cases expressed CD10 only, and one only expressed Bcl6. All these cases were grade 3 tumors and showed follicular and diffuse growth patterns. Conclusions: These results indicate that Smad1 is a candidate as a germinal center marker. Furthermore, they suggest that the Smad signaling pathway might be involved in follicular lymphoma. |
| first_indexed | 2024-12-10T12:06:31Z |
| format | Article |
| id | doaj.art-28fdf85fbb284f958820d229d5ede062 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-10T12:06:31Z |
| publishDate | 2015-05-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-28fdf85fbb284f958820d229d5ede0622022-12-22T01:49:27ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452015-05-0149324324810.4132/jptm.2015.03.3016516Smad1 Expression in Follicular LymphomaJai Hyang GoBackground: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center markers are required. Smad1 has been reported to be overexpressed in follicular lymphoma, but little is known regarding the expression patterns of Smad proteins in human lymphoid tissue. Methods: In the present study, we performed immunohistochemistry for traditional germinal center markers and for Smad1 in human reactive lymphoid and follicular lymphoma tissues to investigate Smad1’s usefulness in the diagnosis of follicular lymphoma. Results: In the reactive germinal centers, most cells were positive for Smad1. Among the 27 follicular lymphoma cases, 17 of 21 (80%) were Smad1 positive, 17 of 27 (63%) were positive for CD10, and 23 of 27 (85%) were positive for Bcl6. Notably, three cases expressed CD10 only, and one only expressed Bcl6. All these cases were grade 3 tumors and showed follicular and diffuse growth patterns. Conclusions: These results indicate that Smad1 is a candidate as a germinal center marker. Furthermore, they suggest that the Smad signaling pathway might be involved in follicular lymphoma.http://www.jpatholtm.org/upload/pdf/jptm-49-3-243.pdfSmad1Bcl6LymphomaFollicular |
| spellingShingle | Jai Hyang Go Smad1 Expression in Follicular Lymphoma Journal of Pathology and Translational Medicine Smad1 Bcl6 Lymphoma Follicular |
| title | Smad1 Expression in Follicular Lymphoma |
| title_full | Smad1 Expression in Follicular Lymphoma |
| title_fullStr | Smad1 Expression in Follicular Lymphoma |
| title_full_unstemmed | Smad1 Expression in Follicular Lymphoma |
| title_short | Smad1 Expression in Follicular Lymphoma |
| title_sort | smad1 expression in follicular lymphoma |
| topic | Smad1 Bcl6 Lymphoma Follicular |
| url | http://www.jpatholtm.org/upload/pdf/jptm-49-3-243.pdf |
| work_keys_str_mv | AT jaihyanggo smad1expressioninfollicularlymphoma |