Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department
Abstract The prognostic implication of cardiac troponin I (cTnI) values for the determination of the magnitude or duration of cause-specific death risk is limited. We included consecutive patients with maximal cTnI values within 24 h of their emergency department visits. Multivariate analyses using...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-96951-y |
| _version_ | 1818683742109040640 |
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| author | Jong Eun Park Minseok Song Taerim Kim Gun Tak Lee Sung Yeon Hwang Hee Yoon Won Chul Cha Tae Gun Shin Min Sub Sim Ik Joon Jo Seung-Hwa Lee Hyung-Doo Park Jin-Ho Choi |
| author_facet | Jong Eun Park Minseok Song Taerim Kim Gun Tak Lee Sung Yeon Hwang Hee Yoon Won Chul Cha Tae Gun Shin Min Sub Sim Ik Joon Jo Seung-Hwa Lee Hyung-Doo Park Jin-Ho Choi |
| author_sort | Jong Eun Park |
| collection | DOAJ |
| description | Abstract The prognostic implication of cardiac troponin I (cTnI) values for the determination of the magnitude or duration of cause-specific death risk is limited. We included consecutive patients with maximal cTnI values within 24 h of their emergency department visits. Multivariate analyses using variables selected by the Bayesian information criterion were performed to investigate the impact of cTnI on the event rate, time-dependent risk, and dose-dependent risk of cardiovascular or non-cardiovascular death within 360 days. There were 5472 (14.9%) all-cause deaths including 881 (2.4%) cardiovascular deaths and 4591 (12.5%) non-cardiovascular deaths. In patients with positive cTnI, defined as the ≥ 99th percentile of the upper normal limit, the cumulative risk of cardiac and non-cardiac death was 4.4- and 1.4-fold higher, respectively, than that of negative cTnI, respectively. In the competing risk analysis, positive cTnI was linked to 2.4- and 1.2-fold higher risks of cardiovascular and non-cardiovascular death, respectively. The cTnI value showed a positive relationship with the risk of both cardiovascular and non-cardiovascular deaths. In the time-dependent risk analysis, the excess risk of cardiovascular death was mostly evident in the first few weeks. Higher cTnI value was associated with an increased risk of both cardiovascular and non-cardiovascular death, especially which was in the early period. |
| first_indexed | 2024-12-17T10:39:34Z |
| format | Article |
| id | doaj.art-28fef70f7a1b4b299e40a72488d37434 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:39:34Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-28fef70f7a1b4b299e40a72488d374342022-12-21T21:52:17ZengNature PortfolioScientific Reports2045-23222021-08-011111810.1038/s41598-021-96951-yCardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency departmentJong Eun Park0Minseok Song1Taerim Kim2Gun Tak Lee3Sung Yeon Hwang4Hee Yoon5Won Chul Cha6Tae Gun Shin7Min Sub Sim8Ik Joon Jo9Seung-Hwa Lee10Hyung-Doo Park11Jin-Ho Choi12Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineAbstract The prognostic implication of cardiac troponin I (cTnI) values for the determination of the magnitude or duration of cause-specific death risk is limited. We included consecutive patients with maximal cTnI values within 24 h of their emergency department visits. Multivariate analyses using variables selected by the Bayesian information criterion were performed to investigate the impact of cTnI on the event rate, time-dependent risk, and dose-dependent risk of cardiovascular or non-cardiovascular death within 360 days. There were 5472 (14.9%) all-cause deaths including 881 (2.4%) cardiovascular deaths and 4591 (12.5%) non-cardiovascular deaths. In patients with positive cTnI, defined as the ≥ 99th percentile of the upper normal limit, the cumulative risk of cardiac and non-cardiac death was 4.4- and 1.4-fold higher, respectively, than that of negative cTnI, respectively. In the competing risk analysis, positive cTnI was linked to 2.4- and 1.2-fold higher risks of cardiovascular and non-cardiovascular death, respectively. The cTnI value showed a positive relationship with the risk of both cardiovascular and non-cardiovascular deaths. In the time-dependent risk analysis, the excess risk of cardiovascular death was mostly evident in the first few weeks. Higher cTnI value was associated with an increased risk of both cardiovascular and non-cardiovascular death, especially which was in the early period.https://doi.org/10.1038/s41598-021-96951-y |
| spellingShingle | Jong Eun Park Minseok Song Taerim Kim Gun Tak Lee Sung Yeon Hwang Hee Yoon Won Chul Cha Tae Gun Shin Min Sub Sim Ik Joon Jo Seung-Hwa Lee Hyung-Doo Park Jin-Ho Choi Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department Scientific Reports |
| title | Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department |
| title_full | Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department |
| title_fullStr | Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department |
| title_full_unstemmed | Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department |
| title_short | Cardiac troponin I and the risk of cardiovascular or non-cardiovascular death in patients visiting the emergency department |
| title_sort | cardiac troponin i and the risk of cardiovascular or non cardiovascular death in patients visiting the emergency department |
| url | https://doi.org/10.1038/s41598-021-96951-y |
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