Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus
Medicinal and aromatic plants’ properties, still an interesting research area, are attributed to the presence of various specialized products that possess important pharmacological activities. In the present study, six medicinal/aromatic plants (<i>Sideritis cypria</i>, <i>Origanum...
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MDPI AG
2024-01-01
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| author | Antonios Chrysargyris Jovana D. Petrovic Ekaterina-Michaela Tomou Kalia Kyriakou Panayiota Xylia Andria Kotsoni Vasiliki Gkretsi Panagiota Miltiadous Helen Skaltsa Marina D. Soković Nikolaos Tzortzakis |
| author_facet | Antonios Chrysargyris Jovana D. Petrovic Ekaterina-Michaela Tomou Kalia Kyriakou Panayiota Xylia Andria Kotsoni Vasiliki Gkretsi Panagiota Miltiadous Helen Skaltsa Marina D. Soković Nikolaos Tzortzakis |
| author_sort | Antonios Chrysargyris |
| collection | DOAJ |
| description | Medicinal and aromatic plants’ properties, still an interesting research area, are attributed to the presence of various specialized products that possess important pharmacological activities. In the present study, six medicinal/aromatic plants (<i>Sideritis cypria</i>, <i>Origanum dubium</i>, <i>Melissa officinalis</i>, <i>Mentha piperita</i>, <i>Thymus capitatus</i>, and <i>Salvia fruticosa</i>) were evaluated for their phytochemical and nutritive composition, as well as their biological activities, including antioxidant, antimicrobial, and cytotoxic properties. The results obtained indicate that <i>M. piperita</i> was rich in proteins and minerals such as N and Mg, while <i>S. cypria</i> accumulated more K, Na, P, and Ca. The highest content of phenols and flavonoids was observed in <i>M. piperita</i>, followed by <i>O. dubium</i> and <i>T. capitatus</i>, which eventually influenced their high antioxidant capacity. NMR screening revealed the presence of (i) triterpenoids and hydroxycinnamic acid derivatives in <i>M. officinalis</i>; (ii) terpenoids, flavonoids, and phenolic acid derivatives in <i>S. fruticosa</i>; (iii) flavonoids and phenolic acid derivatives in <i>M. piperita</i>; (iv) phenolic monoterpenes in <i>O. dubium</i> and <i>T. capitatus</i>; and (v) terpenoids, flavones, and phenylethanoid glycosides in <i>S. cypria</i>. The results of the antimicrobial activity showed that the tested samples overall had quite good antimicrobial potential. High antibacterial activity was found in <i>O. dubium</i> and <i>T. capitatus</i>, while <i>O. dubium</i> and <i>S. cypria</i> exhibited great antifungal activities. The studied species also had an important effect on the viability of female-derived and colon cancer cells. In particular, in colon cancer cells, the extracts from <i>T. capitatus, M. officinalis, M. piperita</i>, and <i>S. fruticosa</i> exhibited a stronger effect on cell viability in the more metastatic cell line at significantly lower concentrations, indicating an important therapeutic potential in targeting highly metastatic tumors. This finding is worth further investigation. The present study unveiled interesting phytochemical profiles and biological properties of the six medicinal/aromatic plants, which should be further explored, contributing to green chemistry and the possible creation of natural health products for humans’ health/nutrition and additives in cosmetics. |
| first_indexed | 2024-03-08T11:04:01Z |
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| last_indexed | 2024-03-08T11:04:01Z |
| publishDate | 2024-01-01 |
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| series | Biology |
| spelling | doaj.art-28ffca2b39f0465a97ce6701c382fabc2024-01-26T15:07:04ZengMDPI AGBiology2079-77372024-01-011314510.3390/biology13010045Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in CyprusAntonios Chrysargyris0Jovana D. Petrovic1Ekaterina-Michaela Tomou2Kalia Kyriakou3Panayiota Xylia4Andria Kotsoni5Vasiliki Gkretsi6Panagiota Miltiadous7Helen Skaltsa8Marina D. Soković9Nikolaos Tzortzakis10Department of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Limassol 3036, CyprusInstitute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11108 Belgrade, SerbiaDepartment of Pharmacognosy & Chemistry of Natural Products, School of Health Sciences, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, GreeceDepartment of Nursing, School of Health Sciences, Cyprus University of Technology, Limassol 3041, CyprusDepartment of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Limassol 3036, CyprusDepartment of Life Sciences, School of Sciences, European University Cyprus, Nicosia 2404, CyprusDepartment of Life Sciences, School of Sciences, European University Cyprus, Nicosia 2404, CyprusDepartment of Nursing, School of Health Sciences, Cyprus University of Technology, Limassol 3041, CyprusDepartment of Pharmacognosy & Chemistry of Natural Products, School of Health Sciences, Faculty of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou, 15771 Athens, GreeceInstitute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11108 Belgrade, SerbiaDepartment of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, Limassol 3036, CyprusMedicinal and aromatic plants’ properties, still an interesting research area, are attributed to the presence of various specialized products that possess important pharmacological activities. In the present study, six medicinal/aromatic plants (<i>Sideritis cypria</i>, <i>Origanum dubium</i>, <i>Melissa officinalis</i>, <i>Mentha piperita</i>, <i>Thymus capitatus</i>, and <i>Salvia fruticosa</i>) were evaluated for their phytochemical and nutritive composition, as well as their biological activities, including antioxidant, antimicrobial, and cytotoxic properties. The results obtained indicate that <i>M. piperita</i> was rich in proteins and minerals such as N and Mg, while <i>S. cypria</i> accumulated more K, Na, P, and Ca. The highest content of phenols and flavonoids was observed in <i>M. piperita</i>, followed by <i>O. dubium</i> and <i>T. capitatus</i>, which eventually influenced their high antioxidant capacity. NMR screening revealed the presence of (i) triterpenoids and hydroxycinnamic acid derivatives in <i>M. officinalis</i>; (ii) terpenoids, flavonoids, and phenolic acid derivatives in <i>S. fruticosa</i>; (iii) flavonoids and phenolic acid derivatives in <i>M. piperita</i>; (iv) phenolic monoterpenes in <i>O. dubium</i> and <i>T. capitatus</i>; and (v) terpenoids, flavones, and phenylethanoid glycosides in <i>S. cypria</i>. The results of the antimicrobial activity showed that the tested samples overall had quite good antimicrobial potential. High antibacterial activity was found in <i>O. dubium</i> and <i>T. capitatus</i>, while <i>O. dubium</i> and <i>S. cypria</i> exhibited great antifungal activities. The studied species also had an important effect on the viability of female-derived and colon cancer cells. In particular, in colon cancer cells, the extracts from <i>T. capitatus, M. officinalis, M. piperita</i>, and <i>S. fruticosa</i> exhibited a stronger effect on cell viability in the more metastatic cell line at significantly lower concentrations, indicating an important therapeutic potential in targeting highly metastatic tumors. This finding is worth further investigation. The present study unveiled interesting phytochemical profiles and biological properties of the six medicinal/aromatic plants, which should be further explored, contributing to green chemistry and the possible creation of natural health products for humans’ health/nutrition and additives in cosmetics.https://www.mdpi.com/2079-7737/13/1/45chemical profilesNMRantioxidant activityantimicrobial activitycytotoxicity |
| spellingShingle | Antonios Chrysargyris Jovana D. Petrovic Ekaterina-Michaela Tomou Kalia Kyriakou Panayiota Xylia Andria Kotsoni Vasiliki Gkretsi Panagiota Miltiadous Helen Skaltsa Marina D. Soković Nikolaos Tzortzakis Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus Biology chemical profiles NMR antioxidant activity antimicrobial activity cytotoxicity |
| title | Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus |
| title_full | Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus |
| title_fullStr | Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus |
| title_full_unstemmed | Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus |
| title_short | Phytochemical Profiles and Biological Activities of Plant Extracts from Aromatic Plants Cultivated in Cyprus |
| title_sort | phytochemical profiles and biological activities of plant extracts from aromatic plants cultivated in cyprus |
| topic | chemical profiles NMR antioxidant activity antimicrobial activity cytotoxicity |
| url | https://www.mdpi.com/2079-7737/13/1/45 |
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