ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth
Integration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and car...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/4/346 |
| _version_ | 1797537036040667136 |
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| author | Christopher J. Gilbert Jacob Z. Longenecker Federica Accornero |
| author_facet | Christopher J. Gilbert Jacob Z. Longenecker Federica Accornero |
| author_sort | Christopher J. Gilbert |
| collection | DOAJ |
| description | Integration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and cardiac stress responses. Considering the importance of ERK1/2 in the heart, understanding how these kinases operate in both normal and disease states is critical. Here, we review the complexity of upstream and downstream signals that govern ERK1/2-dependent regulation of cardiac structure and function. Particular emphasis is given to cardiomyocyte hypertrophy as an outcome of ERK1/2 activation regulation in the heart. |
| first_indexed | 2024-03-10T12:10:20Z |
| format | Article |
| id | doaj.art-29001ea2f085441399703437d3923498 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T12:10:20Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-29001ea2f085441399703437d39234982023-11-21T16:15:59ZengMDPI AGBiology2079-77372021-04-0110434610.3390/biology10040346ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and GrowthChristopher J. Gilbert0Jacob Z. Longenecker1Federica Accornero2Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USADepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USAIntegration of cellular responses to extracellular cues is essential for cell survival and adaptation to stress. Extracellular signal-regulated kinase (ERK) 1 and 2 serve an evolutionarily conserved role for intracellular signal transduction that proved critical for cardiomyocyte homeostasis and cardiac stress responses. Considering the importance of ERK1/2 in the heart, understanding how these kinases operate in both normal and disease states is critical. Here, we review the complexity of upstream and downstream signals that govern ERK1/2-dependent regulation of cardiac structure and function. Particular emphasis is given to cardiomyocyte hypertrophy as an outcome of ERK1/2 activation regulation in the heart.https://www.mdpi.com/2079-7737/10/4/346ERKextracellular matrixheartcardiac hypertrophy |
| spellingShingle | Christopher J. Gilbert Jacob Z. Longenecker Federica Accornero ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth Biology ERK extracellular matrix heart cardiac hypertrophy |
| title | ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth |
| title_full | ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth |
| title_fullStr | ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth |
| title_full_unstemmed | ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth |
| title_short | ERK1/2: An Integrator of Signals That Alters Cardiac Homeostasis and Growth |
| title_sort | erk1 2 an integrator of signals that alters cardiac homeostasis and growth |
| topic | ERK extracellular matrix heart cardiac hypertrophy |
| url | https://www.mdpi.com/2079-7737/10/4/346 |
| work_keys_str_mv | AT christopherjgilbert erk12anintegratorofsignalsthatalterscardiachomeostasisandgrowth AT jacobzlongenecker erk12anintegratorofsignalsthatalterscardiachomeostasisandgrowth AT federicaaccornero erk12anintegratorofsignalsthatalterscardiachomeostasisandgrowth |