Medication-Induced Oral Hyperpigmentation: A Systematic Review
Nada O Binmadi, Maram Bawazir, Nada Alhindi, Hani Mawardi, Ghada Mansour, Sana Alhamed, Sarah Alfarabi, Sara Akeel, Soulafa Almazrooa Oral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Nada O BinmadiOral Diagnostic Sciences Depar...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-10-01
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| Series: | Patient Preference and Adherence |
| Subjects: | |
| Online Access: | https://www.dovepress.com/medication-induced-oral-hyperpigmentation-a-systematic-review-peer-reviewed-article-PPA |
| _version_ | 1819008521187885056 |
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| author | Binmadi NO Bawazir M Alhindi N Mawardi H Mansour G Alhamed S Alfarabi S Akeel S Almazrooa S |
| author_facet | Binmadi NO Bawazir M Alhindi N Mawardi H Mansour G Alhamed S Alfarabi S Akeel S Almazrooa S |
| author_sort | Binmadi NO |
| collection | DOAJ |
| description | Nada O Binmadi, Maram Bawazir, Nada Alhindi, Hani Mawardi, Ghada Mansour, Sana Alhamed, Sarah Alfarabi, Sara Akeel, Soulafa Almazrooa Oral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Nada O BinmadiOral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi ArabiaTel +966505699092Email nmadi@kau.edu.saBackground: Medication-induced oral hyperpigmentation is an oral condition that impacts patients’ quality of life and has been linked to many systemic therapeutic agents. The exact pathogenesis of tissue pigmentation varies greatly and is not completely known. This systematic review aimed to present data on the causal association between medications and the development of oral/mucosal pigmentation as an adverse drug reaction.Methods: A systematic review and analysis of literature were conducted using the following databases: PubMed, Science Direct, ProQuest, Web of Science, and Scopus. The systematic review included original articles written in English and published between January 1982 and June 2020. Following the PRISMA statement, eligible articles were systematically reviewed, and data were extracted from eligible studies and analyzed.Results: A total of 235 articles were identified, of which 57 met the inclusion criteria and were included in this review. The mean age of included patients was 46.2± 16.38 years (range: 10– 90 years) with a male to female ratio of 1:1.45. Oral mucosal hyperpigmentation was reported following the use of several classes of medications such as antiviral (eg, zidovudine), antibiotic (eg, minocycline), antimalarial (eg, chloroquine), anti-fungal (eg, ketoconazole), antileprotic (eg, clofazimine), antihypertensive (eg, amlodipine), chemotherapeutic, and antineoplastic drugs. The risk of developing oral pigmentation was significantly higher with antimalarial medications, antibiotics, antineoplastic and chemotherapeutic agents. Medication-induced oral hyperpigmentation was most frequent among women and in the hard palate.Conclusion: Future research is warranted to better understand the pathogenesis and risk factors for medication-induced oral hyperpigmentation in order to reassure patients during prescription and management.Keywords: medication-induced, oral hyperpigmentation, drugs, adverse reaction, systematic review |
| first_indexed | 2024-12-21T00:41:47Z |
| format | Article |
| id | doaj.art-29011d42520d4d699ccfdb7ab04eb6f7 |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-12-21T00:41:47Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-29011d42520d4d699ccfdb7ab04eb6f72022-12-21T19:21:38ZengDove Medical PressPatient Preference and Adherence1177-889X2020-10-01Volume 141961196858162Medication-Induced Oral Hyperpigmentation: A Systematic ReviewBinmadi NOBawazir MAlhindi NMawardi HMansour GAlhamed SAlfarabi SAkeel SAlmazrooa SNada O Binmadi, Maram Bawazir, Nada Alhindi, Hani Mawardi, Ghada Mansour, Sana Alhamed, Sarah Alfarabi, Sara Akeel, Soulafa Almazrooa Oral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi ArabiaCorrespondence: Nada O BinmadiOral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi ArabiaTel +966505699092Email nmadi@kau.edu.saBackground: Medication-induced oral hyperpigmentation is an oral condition that impacts patients’ quality of life and has been linked to many systemic therapeutic agents. The exact pathogenesis of tissue pigmentation varies greatly and is not completely known. This systematic review aimed to present data on the causal association between medications and the development of oral/mucosal pigmentation as an adverse drug reaction.Methods: A systematic review and analysis of literature were conducted using the following databases: PubMed, Science Direct, ProQuest, Web of Science, and Scopus. The systematic review included original articles written in English and published between January 1982 and June 2020. Following the PRISMA statement, eligible articles were systematically reviewed, and data were extracted from eligible studies and analyzed.Results: A total of 235 articles were identified, of which 57 met the inclusion criteria and were included in this review. The mean age of included patients was 46.2± 16.38 years (range: 10– 90 years) with a male to female ratio of 1:1.45. Oral mucosal hyperpigmentation was reported following the use of several classes of medications such as antiviral (eg, zidovudine), antibiotic (eg, minocycline), antimalarial (eg, chloroquine), anti-fungal (eg, ketoconazole), antileprotic (eg, clofazimine), antihypertensive (eg, amlodipine), chemotherapeutic, and antineoplastic drugs. The risk of developing oral pigmentation was significantly higher with antimalarial medications, antibiotics, antineoplastic and chemotherapeutic agents. Medication-induced oral hyperpigmentation was most frequent among women and in the hard palate.Conclusion: Future research is warranted to better understand the pathogenesis and risk factors for medication-induced oral hyperpigmentation in order to reassure patients during prescription and management.Keywords: medication-induced, oral hyperpigmentation, drugs, adverse reaction, systematic reviewhttps://www.dovepress.com/medication-induced-oral-hyperpigmentation-a-systematic-review-peer-reviewed-article-PPAmedication-inducedoral hyperpigmentationdrugsadverse reaction systematic review |
| spellingShingle | Binmadi NO Bawazir M Alhindi N Mawardi H Mansour G Alhamed S Alfarabi S Akeel S Almazrooa S Medication-Induced Oral Hyperpigmentation: A Systematic Review Patient Preference and Adherence medication-induced oral hyperpigmentation drugs adverse reaction systematic review |
| title | Medication-Induced Oral Hyperpigmentation: A Systematic Review |
| title_full | Medication-Induced Oral Hyperpigmentation: A Systematic Review |
| title_fullStr | Medication-Induced Oral Hyperpigmentation: A Systematic Review |
| title_full_unstemmed | Medication-Induced Oral Hyperpigmentation: A Systematic Review |
| title_short | Medication-Induced Oral Hyperpigmentation: A Systematic Review |
| title_sort | medication induced oral hyperpigmentation a systematic review |
| topic | medication-induced oral hyperpigmentation drugs adverse reaction systematic review |
| url | https://www.dovepress.com/medication-induced-oral-hyperpigmentation-a-systematic-review-peer-reviewed-article-PPA |
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