Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is the most common type of dementia characterized by the abnormal accumulation of amyloid-β (Aβ) in the brain. Aβ misfolding is associated with neuroinflammation and synaptic dysfunction, leading to learning and memory deficits. Therefore, Aβ production and aggregat...

Full description

Bibliographic Details
Main Authors:	Sohui Park, Hye Yun Kim, Hyun-A Oh, Jisu Shin, In Wook Park, Soljee Yoon, Dong Ho Woo, YoungSoo Kim
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-06-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-91563-y

Similar Items

Correction: Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model.
by: DaWon Kim, et al.
Published: (2021-01-01)

Carprofen alleviates Alzheimer-like phenotypes of 5XFAD transgenic mice by targeting the pathological hallmarks induced by amyloid-β aggregation
by: Donghee Lee, et al.
Published: (2023-07-01)

Validation of Fucoxanthin from Microalgae <em>Phaeodactylum tricornutum</em> for the Detection of Amyloid Burden in Transgenic Mouse Models of Alzheimer’s Disease
by: A-Hyeon Lee, et al.
Published: (2021-06-01)

Solid-phase synthesis and pathological evaluation of pyroglutamate amyloid-β3-42 peptide
by: Illhwan Cho, et al.
Published: (2023-01-01)

Chemical‐Driven Outflow of Dissociated Amyloid Burden from Brain to Blood
by: Donghee Lee, et al.
Published: (2022-04-01)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
by: Martina Svensson, et al.
Published: (2021-03-01)

Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models
by: Hee Yang Lee, et al.
Published: (2022-11-01)

4-Hydroxynonenal Immunoreactivity Is Increased in the Frontal Cortex of 5XFAD Transgenic Mice
by: Sang-Wook Shin, et al.
Published: (2020-09-01)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
by: Angelika Sabine Bader, et al.
Published: (2023-04-01)

EVALUATION OF IODODIFLUNISAL DOSE-RESPONSE ON AMYLOID-Β PLAQUES AND NEUROINFLAMMATION IN THE 5XFAD ALZHEIMER'S DISEASE MOUSE MODEL BY PET IMAGING.
by: Claudia Esposito, et al.
Published: (2023-10-01)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
by: Ka Chun Tsui, et al.
Published: (2022-07-01)

Switching On/Off Amyloid Plaque Formation in Transgenic Animal Models of Alzheimer’s Disease
by: Sergey A. Kozin, et al.
Published: (2023-12-01)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
by: Karthivashan Govindarajan, et al.
Published: (2023-07-01)

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
by: Clayton A. Whitmore, et al.
Published: (2022-06-01)

Correction: Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
by: Karthivashan Govindarajan, et al.
Published: (2023-08-01)

Long-Term Administration of <i>Vespa velutina nigrithorax</i> Venom Ameliorates Alzheimer’s Phenotypes in 5xFAD Transgenic Mice
by: Yoon Ah Jeong, et al.
Published: (2023-03-01)

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice
by: Rahim Ullah, et al.
Published: (2021-09-01)

(-)-Oleocanthal Nutraceuticals for Alzheimer’s Disease Amyloid Pathology: Novel Oral Formulations, Therapeutic, and Molecular Insights in 5xFAD Transgenic Mice Model
by: Afsana Tajmim, et al.
Published: (2021-05-01)

Collagenous Alzheimer amyloid plaque component impacts on the compaction of amyloid-β plaques
by: Tadafumi Hashimoto, et al.
Published: (2020-12-01)

Oral Administration of <i>Euonymus alatus</i> Leaf Extract Ameliorates Alzheimer’s Disease Phenotypes in 5xFAD Transgenic Mice
by: Yoonsu Kim, et al.
Published: (2024-02-01)

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
by: Peng Zhao, et al.
Published: (2022-12-01)

Therapeutic Effects of Aripiprazole in the 5xFAD Alzheimer’s Disease Mouse Model
by: Ye Ji Jeong, et al.
Published: (2021-08-01)

Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers
by: Jinny Claire Lee, et al.
Published: (2019-05-01)

Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice
by: Jimin Do, et al.
Published: (2020-06-01)

Sex Differences between Neuronal Loss and the Early Onset of Amyloid Deposits and Behavioral Consequences in 5xFAD Transgenic Mouse as a Model for Alzheimer’s Disease
by: Chi Him Poon, et al.
Published: (2023-03-01)

Galantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease.
by: Soumee Bhattacharya, et al.
Published: (2014-01-01)

Memory deficiency, cerebral amyloid angiopathy, and amyloid-β plaques in APP+PS1 double transgenic rat model of Alzheimer's disease.
by: Diana Klakotskaia, et al.
Published: (2018-01-01)

Protective effects of CCL01 against Aβ-induced neurotoxicity in 5xFAD transgenic mouse model of Alzheimer's disease
by: In Gyoung Ju, et al.
Published: (2023-02-01)

Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer's disease transgenic mice using magnetic resonance microimaging.
by: Youssef Zaim Wadghiri, et al.
Published: (2013-01-01)

Intranasal Delivery of Collagen-Loaded Neprilysin Clears Beta-Amyloid Plaques in a Transgenic Alzheimer Mouse Model
by: Christian Humpel
Published: (2021-04-01)

Long-Term Treatment of Cuban Policosanol Attenuates Abnormal Oxidative Stress and Inflammatory Response via Amyloid Plaques Reduction in 5xFAD Mice
by: Jin-Ho Kim, et al.
Published: (2021-08-01)

Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits.
by: Bowon Kim, et al.
Published: (2020-01-01)

CONTINUED TREATMENT OF D-PINITOL AMELIORATES COGNITIVE SPATIAL FLEXIBILITY OF ALZHEIMER’S DISEASE 5XFAD TRANSGENIC MICE
by: Dina Medina-Vera, et al.
Published: (2023-10-01)

A Transgenic 5xFAD-M Line of Mice for Dendritic Spine Morphology Analysis in Alzheimer’s Disease
by: Anastasiia Ilina, et al.
Published: (2023-02-01)

Maternal separation differentially modulates early pathology by sex in 5xFAD Alzheimer’s disease-transgenic mice
by: M.G. Garcia, et al.
Published: (2023-10-01)

The Dynamics of β-Amyloid Proteoforms Accumulation in the Brain of a 5xFAD Mouse Model of Alzheimer’s Disease
by: Anna E. Bugrova, et al.
Published: (2021-12-01)

Amyloid β Protein Aggravates Neuronal Senescence and Cognitive Deficits in 5XFAD Mouse Model of Alzheimer's Disease
by: Zhen Wei, et al.
Published: (2016-01-01)

Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer’s disease-like transgenic (pPDGF-APPSw,Ind) mice
by: Li Gan, et al.
Published: (2008-01-01)

Area-specific alterations of synaptic plasticity in the 5XFAD mouse model of Alzheimer's disease: dissociation between somatosensory cortex and hippocampus.
by: Nadine Crouzin, et al.
Published: (2013-01-01)

Optical Imaging of Beta-Amyloid Plaques in Alzheimer’s Disease
by: Ziyi Luo, et al.
Published: (2021-07-01)